Unraveling Ferroptosis: A New Frontier in Combating Renal Fibrosis and CKD Progression DOI Creative Commons
Rui Jin, Yue Dai, Zheng Wang

et al.

Biology, Journal Year: 2024, Volume and Issue: 14(1), P. 12 - 12

Published: Dec. 27, 2024

Chronic kidney disease (CKD) is a global health concern caused by conditions such as hypertension, diabetes, hyperlipidemia, and chronic nephritis, leading to structural functional injury. Kidney fibrosis common outcome of CKD progression, with abnormal fatty acid oxidation (FAO) disrupting renal energy homeostasis impairments. This results in maladaptive repair mechanisms the secretion profibrotic factors, exacerbates fibrosis. Understanding molecular crucial for delaying progression. Ferroptosis type discovered an iron-dependent lipid peroxidation-regulated cell death. Notably, contributes tissue organ fibrosis, which correlated degree study aims clarify complex ferroptosis parenchymal cells explore how intervention may help alleviate particularly addressing gap related metabolism under context. The goal provide new theoretical basis clinically

Language: Английский

SIRT6 attenuates calcium oxalate Nephrocalcinosis-induced renal inflammation and oxidative injury via activating NRF2 signaling DOI
Lvwen Zhang, Zhenyu Song, X. Mao

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114302 - 114302

Published: Feb. 18, 2025

Language: Английский

Citations

0
Unraveling Ferroptosis: A New Frontier in Combating Renal Fibrosis and CKD Progression DOI Creative Commons
Rui Jin, Yue Dai, Zheng Wang

et al.

Biology, Journal Year: 2024, Volume and Issue: 14(1), P. 12 - 12

Published: Dec. 27, 2024

Chronic kidney disease (CKD) is a global health concern caused by conditions such as hypertension, diabetes, hyperlipidemia, and chronic nephritis, leading to structural functional injury. Kidney fibrosis common outcome of CKD progression, with abnormal fatty acid oxidation (FAO) disrupting renal energy homeostasis impairments. This results in maladaptive repair mechanisms the secretion profibrotic factors, exacerbates fibrosis. Understanding molecular crucial for delaying progression. Ferroptosis type discovered an iron-dependent lipid peroxidation-regulated cell death. Notably, contributes tissue organ fibrosis, which correlated degree study aims clarify complex ferroptosis parenchymal cells explore how intervention may help alleviate particularly addressing gap related metabolism under context. The goal provide new theoretical basis clinically

Language: Английский

Citations

1