
Biology, Journal Year: 2024, Volume and Issue: 14(1), P. 12 - 12
Published: Dec. 27, 2024
Chronic kidney disease (CKD) is a global health concern caused by conditions such as hypertension, diabetes, hyperlipidemia, and chronic nephritis, leading to structural functional injury. Kidney fibrosis common outcome of CKD progression, with abnormal fatty acid oxidation (FAO) disrupting renal energy homeostasis impairments. This results in maladaptive repair mechanisms the secretion profibrotic factors, exacerbates fibrosis. Understanding molecular crucial for delaying progression. Ferroptosis type discovered an iron-dependent lipid peroxidation-regulated cell death. Notably, contributes tissue organ fibrosis, which correlated degree study aims clarify complex ferroptosis parenchymal cells explore how intervention may help alleviate particularly addressing gap related metabolism under context. The goal provide new theoretical basis clinically
Language: Английский