Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease DOI Creative Commons
Wei Li, Wenkang Gao, S D Yan

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 13(1), P. 74 - 74

Published: Dec. 31, 2024

The global incidence and mortality rates of alcohol-related liver disease are on the rise, reflecting a growing health concern worldwide. Alcohol-related develops due to complex interplay multiple reasons, including oxidative stress generated during metabolism ethanol, immune response activated by immunogenic substances, subsequent inflammatory processes. Recent research highlights gut microbiota’s significant role in progression disease. In patients with disease, relative abundance pathogenic bacteria, Enterococcus faecalis, increases is positively correlated level severity exhibited Supplement probiotics like Lactobacillus, as well Bifidobacterium, have been found alleviate microbiota speculated trigger specific signaling pathways, influence metabolite profiles, modulate responses liver. This aimed investigate microorganisms onset advancement uncover underlying mechanisms which may contribute its development. review outlines current treatments for reversing dysbiosis, probiotics, fecal transplantation, targeted phage therapy. Particularly, therapy will be vital aspect future treatment. It hoped that this article prove beneficial treatment

Language: Английский

Discovery of N-Phenylphthalimides Containing Ether Moiety as Potential Protoporphyrinogen IX Oxidase Inhibitors DOI
Geng Wang, Wei Zhang,

Qiong Lei

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: 73(11), P. 6599 - 6609

Published: March 5, 2025

The discovery of novel protoporphyrinogen IX oxidase (PPO) inhibitors has become a key focus in herbicide development. To explore new PPO inhibitors, series N-phenylphthalimide derivatives with ether moieties were designed and successfully synthesized. Among these, compound B18 (Ki = 10.3 nM) exhibited strong inhibitory effect on NtPPO, outperforming flumiclorac-pentyl 46.3 flumioxazin 52.0 nM). It is noted that compounds A3, B18, B19, B20 showed broad-spectrum herbicidal activity against the tested weeds at 75 g a.i./ha. In addition, results molecular simulation density functional theory (DFT) calculations indicated possessed not only robust hydrogen bond Arg98 NtPPO but also superior chemical reactivity, electrostatic field, polarity. Therefore, may be regarded as promising lead for development high-efficiency inhibitors.

Language: Английский

Citations

0
Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease DOI Creative Commons
Wei Li, Wenkang Gao, S D Yan

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 13(1), P. 74 - 74

Published: Dec. 31, 2024

The global incidence and mortality rates of alcohol-related liver disease are on the rise, reflecting a growing health concern worldwide. Alcohol-related develops due to complex interplay multiple reasons, including oxidative stress generated during metabolism ethanol, immune response activated by immunogenic substances, subsequent inflammatory processes. Recent research highlights gut microbiota’s significant role in progression disease. In patients with disease, relative abundance pathogenic bacteria, Enterococcus faecalis, increases is positively correlated level severity exhibited Supplement probiotics like Lactobacillus, as well Bifidobacterium, have been found alleviate microbiota speculated trigger specific signaling pathways, influence metabolite profiles, modulate responses liver. This aimed investigate microorganisms onset advancement uncover underlying mechanisms which may contribute its development. review outlines current treatments for reversing dysbiosis, probiotics, fecal transplantation, targeted phage therapy. Particularly, therapy will be vital aspect future treatment. It hoped that this article prove beneficial treatment

Language: Английский

Citations

0