Dynamic Boronate Ester Based Hydrogel with Enhanced Mechanical Properties and Multi-Stimuli-Triggered Release for Tissue Repair and Antioxidant Therapy DOI Creative Commons
Fangyi Liu, Gaoyang Li, Zi Liang An

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(5), P. 370 - 370

Published: May 18, 2025

Oxidative stress and chronic inflammation play pivotal roles in causing impaired tissue regeneration delaying wound healing processes. Epigallocatechin gallate (EGCG) demonstrates robust anti-inflammatory antioxidant characteristics, thereby emerging as a highly promising therapeutic substance for repair applications. In order to counteract the pathological characteristics of microenvironment, including increased levels reactive oxygen species (ROS), low pH (weak acidic conditions), elevated glucose concentrations, hydrogel with pH/ROS/glucose-responsive properties was fabricated. This modified phenylboronic acid (PBA) groups, which not only enhance its mechanical strength but also endow it multi-stimuli responsiveness via dynamic boronate ester bonds. The impacts grafting PBA loading EGCG on rheological properties, well network structure hydrogels, were systematically investigated. Moreover, vitro experiments showed that could achieve excellent sustained controlled release both small-molecule macromolecular drugs. Additionally, cell viability tests verified hydrogel’s outstanding biocompatibility, demonstrated efficient ability scavenge intracellular ROS. conclusion, this injectable biodegradable possesses responsiveness, controllable drug behavior, capacity, presenting approach alleviate oxidative damage promote repair. study offers valuable perspectives design advanced materials aimed at treating healing.

Language: Английский

In vivo validation of a smart sensor-enabled dressing for remote wound monitoring DOI
Brent Godau, Armando Jardim, Erik Pagan

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117474 - 117474

Published: April 1, 2025

Language: Английский

Citations

0
Dynamic Boronate Ester Based Hydrogel with Enhanced Mechanical Properties and Multi-Stimuli-Triggered Release for Tissue Repair and Antioxidant Therapy DOI Creative Commons
Fangyi Liu, Gaoyang Li, Zi Liang An

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(5), P. 370 - 370

Published: May 18, 2025

Oxidative stress and chronic inflammation play pivotal roles in causing impaired tissue regeneration delaying wound healing processes. Epigallocatechin gallate (EGCG) demonstrates robust anti-inflammatory antioxidant characteristics, thereby emerging as a highly promising therapeutic substance for repair applications. In order to counteract the pathological characteristics of microenvironment, including increased levels reactive oxygen species (ROS), low pH (weak acidic conditions), elevated glucose concentrations, hydrogel with pH/ROS/glucose-responsive properties was fabricated. This modified phenylboronic acid (PBA) groups, which not only enhance its mechanical strength but also endow it multi-stimuli responsiveness via dynamic boronate ester bonds. The impacts grafting PBA loading EGCG on rheological properties, well network structure hydrogels, were systematically investigated. Moreover, vitro experiments showed that could achieve excellent sustained controlled release both small-molecule macromolecular drugs. Additionally, cell viability tests verified hydrogel’s outstanding biocompatibility, demonstrated efficient ability scavenge intracellular ROS. conclusion, this injectable biodegradable possesses responsiveness, controllable drug behavior, capacity, presenting approach alleviate oxidative damage promote repair. study offers valuable perspectives design advanced materials aimed at treating healing.

Language: Английский

Citations

0