Synthesis of Closely‐Contacted Cu2O‐CoWO4 Nanosheet Composites for Cuproptosis Therapy to Tumors With Sonodynamic and Photothermal Assistance DOI Creative Commons

Zhuoran Yang,

Zhuo Li, Chunyu Yang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 21, 2024

Abstract Cuproptosis offers a promising and selective therapeutic strategy for cancer therapy. To fully realize its potential, the development of novel cuproptosis agents achievement efficient copper release are critical steps forward. Herein, closely‐contacted Cu 2 O‐CoWO 4 nanosheet heterojunctions (CCW‐NH) successfully synthesized using an in‐situ process The ions from CCW‐NH can be triggered by ultrasound irradiation, primarily due to generation superoxide radicals as sonodynamic via Z‐scheme charge transfer mechanism. When subjected combined effects laser effective is increased 1.7 times compared untreated group, significantly enhancing efficiency cuproptosis. And incorporation L‐arginine into temperature‐sensitive injectable hydrogel (HP‐CCW@LA) ultimately achieved tumor inhibition rate up 95.1%. L‐arginine, serving reducing agent, enabled sustained highly active + during treatment. Notably, after treating tumors with HP‐CCW@LA, microenvironment leveraged promote ion conversion, which potential monitoring therapy efficacy through magnetic resonance imaging. This work integrated new evaluation.

Language: Английский

A Copper‐Based Photothermal‐Responsive Nanoplatform Reprograms Tumor Immunogenicity via Self‐Amplified Cuproptosis for Synergistic Cancer Therapy DOI Creative Commons
Rukun Cheng, Zhenhao Li,

Weican Luo

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Studies show that intracellular accumulation of copper ions causes cuproptosis, potentially enhancing anticancer immunity. However, the induction cuproptosis inevitably faces challenges due to low deliver efficiency and collateral damage normal tissues. This paper presents a self-amplified nanoplatform (CEL NP) composed Cu2- XS hollow nanospheres (HNSs), elesclomol (ES), phase-change material lauric acid (LA). Under NIR-II laser irradiation, photothermal energy generated by HNSs melts LA, facilitating precise release ES within tumor microenvironment. Notably, can traverse cell membrane form ES-Cu(II) complexes, thereby delivery cells. Excess Cu(II) also reacts with endogenous glutathione, reducing its inhibitory effect on cuproptosis. Ultimately, this amplified activate immunogenic death, eliciting robust immune response promoting suppression. The CEL NP-mediated offers novel approach for therapy through induction.

Language: Английский

Citations

0
Synthesis of Closely‐Contacted Cu2O‐CoWO4 Nanosheet Composites for Cuproptosis Therapy to Tumors With Sonodynamic and Photothermal Assistance DOI Creative Commons

Zhuoran Yang,

Zhuo Li, Chunyu Yang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 21, 2024

Abstract Cuproptosis offers a promising and selective therapeutic strategy for cancer therapy. To fully realize its potential, the development of novel cuproptosis agents achievement efficient copper release are critical steps forward. Herein, closely‐contacted Cu 2 O‐CoWO 4 nanosheet heterojunctions (CCW‐NH) successfully synthesized using an in‐situ process The ions from CCW‐NH can be triggered by ultrasound irradiation, primarily due to generation superoxide radicals as sonodynamic via Z‐scheme charge transfer mechanism. When subjected combined effects laser effective is increased 1.7 times compared untreated group, significantly enhancing efficiency cuproptosis. And incorporation L‐arginine into temperature‐sensitive injectable hydrogel (HP‐CCW@LA) ultimately achieved tumor inhibition rate up 95.1%. L‐arginine, serving reducing agent, enabled sustained highly active + during treatment. Notably, after treating tumors with HP‐CCW@LA, microenvironment leveraged promote ion conversion, which potential monitoring therapy efficacy through magnetic resonance imaging. This work integrated new evaluation.

Language: Английский

Citations

2