Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 1, 2025

Discectomy-induced ferroptosis of nucleus pulposus cells (NPCs) contributes to postoperative lumbar disc herniation (LDH) recurrence and intervertebral degeneration (IDD). We discover that progenitor (NPPCs) could imprint resistance into NPCs through exosome-dependent intercellular transmission miR-221-3p. Based on these findings, we first develop synthetically-tailored NPPC-derived exosomes with enhanced miR-221-3p expression NPC uptake capacity, which are integrated an injectable hydrogel based extracellular matrix (ECM) analogues. The ECM-mimetic (HACS) serves as a biomimetic filler for the post-operative care herniated discs, be facilely injected discectomy-established (NP) cavity localized treatment. HACS-mediated in-situ exosome release in NP enables marked inhibition not only prevents LDH but also reverses IDD symptoms, leading robust restoration structure functions. In summary, this study offers promising approach treating herniation.

Language: Английский

Ferroptosis as a key player in the pathogenesis and intervention therapy in liver injury: focusing on drug-induced hepatotoxicity

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский