The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 562 - 562

Published: Feb. 24, 2025

Background/Objectives. Chronic wounds pose a substantial global healthcare burden exacerbated by aging populations and the increasing prevalence of conditions such as diabetes, peripheral vascular disease, venous insufficiency. Impaired physiological repair mechanisms, including angiogenesis, collagen synthesis, re-epithelialization, hinder healing process in chronic wounds. Many these processes are dependent on their interaction with copper. We hypothesized that targeted delivery copper ions to wound bed would enhance healing. Methods. Wound dressings impregnated oxide microparticles were designed ensure controlled release ions. The efficacy was evaluated using non-infected models, diabetic mouse models compared against control silver dressings. Outcome measures included closure rates, epidermal skin quality assessed histopathological examination, gene expression profiling. Clinical applications through diverse case studies trials involving management. Results. Copper significantly accelerated enhanced angiogenesis Histopathological analyses revealed faster granulation tissue formation, regeneration, neovascularization. Gene showed upregulation critical angiogenic factors VEGF HIF-1α. Investigations clinical observations corroborated improved across various types, Conclusions. is essential for healing, copper-impregnated provide promising solution By enhancing go beyond antimicrobial action, offering cost-effective innovative alternative conventional therapies. represent transformative advancement addressing challenges care.

Language: Английский

Recent Advances on Chitosan-Based Thermosensitive Hydrogels for Skin Wound Treatment

Biology, Journal Year: 2025, Volume and Issue: 14(6), P. 619 - 619

Published: May 27, 2025

Thermosensitive hydrogel, as a smart polymer material, showed great potential for application in the field of wound repair due to its unique external temperature responsiveness and excellent biocompatibility. Chitosan, natural macromolecular polysaccharide derived from deacetylation chitin, possessed not only strong interactions with biomolecules such DNA, proteins, lipids, but also biocompatibility degradability. Chitosan-based thermosensitive hydrogels, prepared by compounding chitosan surfactants, underwent sol–gel phase transitions at varying temperatures, which provided an ideal healing environment wounds. This comprehensive review was initiated elucidating transformation mechanism underlying hydrogels intricate process repair. In addition, this detailed overview prevalent types chitosan-based highlighting their characteristics applications different Finally, challenges development directions were discussed, aiming provide theoretical support practical guidance future healing.

Language: Английский