Morning Awakening Sets the Tone for the Day: The Role of Fronto-Limbic Circuitry in the Proactive Preparation of Cortisol Awakening Response for Emotion Processing in Male Adults DOI Creative Commons
Changming Chen, Bingsen Xiong, Wei Tan

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121251 - 121251

Published: May 1, 2025

The cortisol awakening response (CAR) has been linked to a variety of emotion-related psychiatric conditions and is proposed prepare the brain for upcoming stress challenges. Yet, underlying neurobiological mechanisms such proactive effects on emotional processing remain elusive. In current double-blinded, pharmacologically-manipulated study, 36 male adults (DXM group) received cortisol-repressive dexamethasone previous night, then performed Emotional Face Matching Task (EFMT) during fMRI scanning next afternoon. Relative placebo group (31 males), DXM exhibited lower accuracy in emotion matching condition (p < 0.01), but not sensorimotor control shape condition. ROI-to-voxel psychophysiological interaction (PPI) analyses revealed significant task-by-group involving right left amygdala, medial orbitofrontal cortex (MOFC) or hippocampus. Specifically, stronger functional connectivity between amygdala dorsolateral prefrontal (lDLPFC) 0.001) reduced same network matching, as compared = 0.023). Meanwhile, weaker amygdala-right posterior middle temporal gyrus (rMTG) than 0.001), there was no effect 0.392). These results indicate that CAR proactively prepares fronto-limbic organization adults. findings support causal link its processing, suggest model CAR-mediated preparedness where sets tonic tone day actively regulate neuroendocrinological responses emotionally charged stimuli moment-to-moment basis.

Language: Английский

Morning Awakening Sets the Tone for the Day: The Role of Fronto-Limbic Circuitry in the Proactive Preparation of Cortisol Awakening Response for Emotion Processing in Male Adults DOI Creative Commons
Changming Chen, Bingsen Xiong, Wei Tan

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121251 - 121251

Published: May 1, 2025

The cortisol awakening response (CAR) has been linked to a variety of emotion-related psychiatric conditions and is proposed prepare the brain for upcoming stress challenges. Yet, underlying neurobiological mechanisms such proactive effects on emotional processing remain elusive. In current double-blinded, pharmacologically-manipulated study, 36 male adults (DXM group) received cortisol-repressive dexamethasone previous night, then performed Emotional Face Matching Task (EFMT) during fMRI scanning next afternoon. Relative placebo group (31 males), DXM exhibited lower accuracy in emotion matching condition (p < 0.01), but not sensorimotor control shape condition. ROI-to-voxel psychophysiological interaction (PPI) analyses revealed significant task-by-group involving right left amygdala, medial orbitofrontal cortex (MOFC) or hippocampus. Specifically, stronger functional connectivity between amygdala dorsolateral prefrontal (lDLPFC) 0.001) reduced same network matching, as compared = 0.023). Meanwhile, weaker amygdala-right posterior middle temporal gyrus (rMTG) than 0.001), there was no effect 0.392). These results indicate that CAR proactively prepares fronto-limbic organization adults. findings support causal link its processing, suggest model CAR-mediated preparedness where sets tonic tone day actively regulate neuroendocrinological responses emotionally charged stimuli moment-to-moment basis.

Language: Английский

Citations

0