Computer reconstruction of gene networks controlling anxiety levels in humans and laboratory mice DOI Creative Commons
Eugeny G. Vergunov, V. A. Savostyanov, A. A. Makarova

et al.

Vavilov Journal of Genetics and Breeding, Journal Year: 2025, Volume and Issue: 29(1), P. 162 - 170

Published: March 4, 2025

Anxiety is a normotypic human condition, and like any other emotion has an adaptive value. But excessively high or low anxiety negative consequences for adaptation, which primarily determines the importance of studying these two extreme conditions. At same time, it known that perception aversive stimuli associated with leads to changes in activity brain’s cingulate cortex. The advantage animals as models genetic bases humans ability subtly control external conditions formation certain state, availability brain tissues, create study transgenic models, including through use differentially expressed genes small laboratory from family Muridae anxiety. Within framework translational approach, three-domain potential gene network, generalized humans, was reconstructed using mouse different levels by automatically analyzing texts scientific articles. One domain reduced second increased anxiety, third dispatcher who activates one domains depending on status organism (genetic, epigenetic, physiological). Stages work: (I) A list cortex wild type CD-1 line NCBI GEO database (experiment GSE29014). Using tools this database, differences expression were revealed groups mice (relatively normal) (II) Search orthologs DEG OMA Orthology database. (III) Computer reconstruction ANDSystem cognitive system based (a) orthologous stage (III), (b) MalaCards proven methods approach networks behavior regulation can be used identify molecular markers personality traits, propensity psychopathology.

Language: Английский

Computer reconstruction of gene networks controlling anxiety levels in humans and laboratory mice DOI Creative Commons
Eugeny G. Vergunov, V. A. Savostyanov, A. A. Makarova

et al.

Vavilov Journal of Genetics and Breeding, Journal Year: 2025, Volume and Issue: 29(1), P. 162 - 170

Published: March 4, 2025

Anxiety is a normotypic human condition, and like any other emotion has an adaptive value. But excessively high or low anxiety negative consequences for adaptation, which primarily determines the importance of studying these two extreme conditions. At same time, it known that perception aversive stimuli associated with leads to changes in activity brain’s cingulate cortex. The advantage animals as models genetic bases humans ability subtly control external conditions formation certain state, availability brain tissues, create study transgenic models, including through use differentially expressed genes small laboratory from family Muridae anxiety. Within framework translational approach, three-domain potential gene network, generalized humans, was reconstructed using mouse different levels by automatically analyzing texts scientific articles. One domain reduced second increased anxiety, third dispatcher who activates one domains depending on status organism (genetic, epigenetic, physiological). Stages work: (I) A list cortex wild type CD-1 line NCBI GEO database (experiment GSE29014). Using tools this database, differences expression were revealed groups mice (relatively normal) (II) Search orthologs DEG OMA Orthology database. (III) Computer reconstruction ANDSystem cognitive system based (a) orthologous stage (III), (b) MalaCards proven methods approach networks behavior regulation can be used identify molecular markers personality traits, propensity psychopathology.

Language: Английский

Citations

0