Exercise-induced modulation of miRNAs and gut microbiome: a holistic approach to neuroprotection in Alzheimer’s disease DOI
Rui Wang, Juan Li, Xiaochen Li

et al.

Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is marked by cognitive decline, neuroinflammation, and neuronal loss. MicroRNAs (miRNAs) have emerged as critical regulators of gene expression, influencing key pathways involved in neuroinflammation neurodegeneration AD. This review delves into the multifaceted role exercise modulating miRNA expression its interplay with gut microbiome, proposing comprehensive framework for neuroprotection By synthesizing current research, we elucidate how exercise-induced changes profiles can mitigate inflammatory responses, promote neurogenesis, reduce amyloid-beta tau pathologies. Additionally, explore gut–brain axis, highlighting exercise-driven alterations microbiota composition further influence thereby enhancing function reducing neuroinflammatory markers. holistic approach underscores potential targeting exercise-regulated miRNAs microbiome interactions novel, noninvasive therapeutic strategy to decelerate AD progression improve quality life patients. aims patient outcomes, offering promising avenue effectiveness management.

Language: Английский

Broad-spectrum anti-inflammatory and antioxidant therapy of inflammatory-storm actuated diseases via programmable self-derived cryo-dead neutrophils DOI
Bin Li,

Qiuxia Gao,

Yunxia Wu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160643 - 160643

Published: Feb. 1, 2025

Language: Английский

Citations

1
Tigecycline Modulates LPS-Induced Inflammatory Response in Sepsis Via NF-κB Signalling Pathways: Experimental Insights into Immune Regulation DOI
Lu Zhang, Jun Li,

Meiqing Feng

et al.

International Journal of Antimicrobial Agents, Journal Year: 2025, Volume and Issue: unknown, P. 107496 - 107496

Published: March 1, 2025

Language: Английский

Citations

1
Baicalin-loaded peony seed polypeptide nanoparticles via a pH-driven method: Characterization, release kinetics, and in vitro anti-inflammatory effects DOI
Nan Chen, Hui Sun, Mu-xuan Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142958 - 142958

Published: April 1, 2025

Language: Английский

Citations

0
Fruit‐Based Diet and Gut Health: A Review DOI Creative Commons
Sammra Maqsood,

Muhammad Tayyab Arshad,

Ali Ikram

et al.

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(5)

Published: April 30, 2025

Gut health is essential to the overall well-being of a human being due its implication on digestion, performance immune system, and nutritional absorption. The gut microbiota represents an intricate ecology bacteria, fungi, viruses, important in regulating response maintaining intestinal health. Fruit-based diets have developed as constituent health, current studies highlight nutrition modulating composition activity. Rich fiber, polyphenols, vitamins, antioxidants, fruits also expand immunological function, subordinate inflammation stomach, boost microbial diversity. article reviews benefits fruit-derived dietary fibers, which assist prebiotics fostering development beneficial decreasing inflammation. These antioxidants include flavonoids carotenoids, whose immunomodulatory properties are under investigation for therapeutic use autoimmune diseases, infections, inflammatory bowel disease (IBD). Some particular interest bananas, apples, citrus, berries, consistently shown their gastrointestinal effects. There still barriers increasing fruit intake, including socioeconomic restrictions need personalized counseling. review fills existing gap literature. It encourages enhanced by combining most recent research with practical recommendations implementing fruit-based into daily nutrition.

Language: Английский

Citations

0
The effect of heat-inactivated BBMN68 on immune regulation and gut microbiota in immunosuppressed mice and exploration of its immunomodulation postbiotic functional components DOI Creative Commons
Limian Zhou,

Huiyu Chen,

Jingjing He

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143758 - 143758

Published: April 1, 2025

Language: Английский

Citations

0
Lactylation as a metabolic epigenetic modification: Mechanistic insights and regulatory pathways from cells to organs and diseases DOI
Cong Chen, Jie Wang, Xueying Zhu

et al.

Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156289 - 156289

Published: May 1, 2025

Language: Английский

Citations

0
Dietary Melatonin Supplementation Improved Intestinal Health and Immune Function of Pacific White Shrimp (Litopenaeus vannamei) Under High Alkali Stress DOI Creative Commons
Yiming Li,

Yucong Ye,

Haojuan Yuan

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 772 - 772

Published: May 12, 2025

The intestinal tract serves as a critical immune regulator in aquatic species, maintaining homeostasis and environmental stress resistance. This study evaluates the protective effects of melatonin (MT) on Litopenaeus vannamei (L. vannamei) under acute alkaline through comprehensive analysis morphology, antioxidant responses, apoptosis regulation, microbial community dynamics. A total six groups treatment were designed. After another 2 months breeding, 96 h alkalinity experiment was conducted. Experimental supplementation revealed dose-dependent outcomes: 82.7 mg/kg MT significantly improved survival rates without affecting growth parameters, while higher concentrations (329.2 mg/kg) induced elevated (p < 0.05). Histological examination demonstrated mitigated structural damage MT-treated compared to non-supplemented controls stress. Antioxidant capacity initially increased then stabilized at optimal doses (82.7–165.1 mg/kg), accompanied by enhanced marker expression Microbial profiling indicated MT-mediated enrichment commensal bacteria associated with polysaccharide metabolism, energy utilization, immunity. establishes that exerts protection L. stress, balancing enhancement, modulation, microbiome regulation fortify health, 82.7–165.1 identified therapeutic range for mitigating compromising physiological homeostasis. results this establish an empirical framework optimizing application crustacean aquaculture, particularly highlighting its role barrier integrity challenges.

Language: Английский

Citations

0
Exercise-induced modulation of miRNAs and gut microbiome: a holistic approach to neuroprotection in Alzheimer’s disease DOI
Rui Wang, Juan Li, Xiaochen Li

et al.

Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is marked by cognitive decline, neuroinflammation, and neuronal loss. MicroRNAs (miRNAs) have emerged as critical regulators of gene expression, influencing key pathways involved in neuroinflammation neurodegeneration AD. This review delves into the multifaceted role exercise modulating miRNA expression its interplay with gut microbiome, proposing comprehensive framework for neuroprotection By synthesizing current research, we elucidate how exercise-induced changes profiles can mitigate inflammatory responses, promote neurogenesis, reduce amyloid-beta tau pathologies. Additionally, explore gut–brain axis, highlighting exercise-driven alterations microbiota composition further influence thereby enhancing function reducing neuroinflammatory markers. holistic approach underscores potential targeting exercise-regulated miRNAs microbiome interactions novel, noninvasive therapeutic strategy to decelerate AD progression improve quality life patients. aims patient outcomes, offering promising avenue effectiveness management.

Language: Английский

Citations

0