Goat Milk-Derived Extracellular Vesicles Alleviate Colitis Potentially Through Improved Gut Microbiota in Mice DOI Creative Commons
Xinru Wang, Yi Liu, Chang Hong

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1514 - 1514

Published: April 26, 2025

Ulcerative colitis (UC) is characterized clinically by intestinal inflammation and gut microbiota dysbiosis. The consumption of biologics, although effective in control, may lead to adverse effects inconvenient for at-home administration. Goat milk-derived extracellular vesicles (GMEVs) have been proposed as a supplement prevent inflammation. However, their therapeutic potential remains elusive. This study aimed explore the preventive effect GMEVs on its underlying mechanisms through microbiota-immune axis using dextran sodium sulfate (DSS)-induced mouse model. We found that pre-treatment 20 mg/kg/d effectively prevented body weight loss, colon shortening, depletion colonic goblet cells, disappearance crypts, while enhancing mucosal barrier. Consistent with these phenotypes, GMEV increased levels IL-22 IL-10 decreased IL-1β, TNF-α, IL-6, iNOS. themselves had no normal mice. Paralleling alleviation inflammation, also restored reduction unclassified Muribaculaceae, Dubosiella, Lactobacillus suppressed expansion Alistipes Proteobacteria following DSS treatment. Additionally, intake significantly downregulated expression proteins NF-κB signaling pathway induced DSS. In summary, could regulating barrier, microbiota, organ damage, immune microenvironment. demonstrated application prospects UC prevention.

Language: Английский

Combination therapy with immune checkpoint inhibitors in colorectal cancer: Challenges, resistance mechanisms, and the role of microbiota DOI
Ali Rahimi,

Zeinab Baghernejadan,

Ali Hazrati

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118014 - 118014

Published: March 31, 2025

Language: Английский

Citations

0
Goat Milk-Derived Extracellular Vesicles Alleviate Colitis Potentially Through Improved Gut Microbiota in Mice DOI Creative Commons
Xinru Wang, Yi Liu, Chang Hong

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1514 - 1514

Published: April 26, 2025

Ulcerative colitis (UC) is characterized clinically by intestinal inflammation and gut microbiota dysbiosis. The consumption of biologics, although effective in control, may lead to adverse effects inconvenient for at-home administration. Goat milk-derived extracellular vesicles (GMEVs) have been proposed as a supplement prevent inflammation. However, their therapeutic potential remains elusive. This study aimed explore the preventive effect GMEVs on its underlying mechanisms through microbiota-immune axis using dextran sodium sulfate (DSS)-induced mouse model. We found that pre-treatment 20 mg/kg/d effectively prevented body weight loss, colon shortening, depletion colonic goblet cells, disappearance crypts, while enhancing mucosal barrier. Consistent with these phenotypes, GMEV increased levels IL-22 IL-10 decreased IL-1β, TNF-α, IL-6, iNOS. themselves had no normal mice. Paralleling alleviation inflammation, also restored reduction unclassified Muribaculaceae, Dubosiella, Lactobacillus suppressed expansion Alistipes Proteobacteria following DSS treatment. Additionally, intake significantly downregulated expression proteins NF-κB signaling pathway induced DSS. In summary, could regulating barrier, microbiota, organ damage, immune microenvironment. demonstrated application prospects UC prevention.

Language: Английский

Citations

0