Nanoengineering of Phosphate/Phosphonate Drugs via Competitive Replacement with Metal‐Phenolic Networks to Overcome Breast Tumor with Lung and Bone Metastasis DOI Creative Commons

Wanrui Shi,

Dashuai Liu,

Wenjie Feng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 18, 2024

Abstract Phosphate and phosphonate drugs are vital in building organisms, regulating physiological processes, exhibiting diverse biological activities, including antiviral, antibacterial, antineoplastic, enzyme‐inhibitory effects. However, their therapeutic potential is limited by the lack of advanced nanoengineering technologies. Herein, a competitive coordination strategy for phosphate/phosphonate introduced. By leveraging difference capabilities between polyphenols phosphates/phosphonates with metal ions, various phosphate/phosphonate‐based nanodrugs using metal‐phenolic networks (MPNs) as templates agents constructed. The dynamic nature these bonds imparts stimuli‐responsiveness to nanodrugs, allowing targeted release therapy. As proof concept, Fe 3+ galangin used form MPN template, zoledronic acid cGAMP agents, DOX loaded drug construct DOX@Fe‐galangin@Fe‐zoledronic acid‐cGAMP nanodrugs. results demonstrate that, triggering pyroptosis activating cGAS‐STING pathway, exhibit potent cytotoxicity accurate selectivity eradicating orthotopic breast tumors, activate an antitumor immune response against lung bone metastases. Because applicable variety it holds significant enhancing clinical efficacy advancing nanodrug development complex applications.

Language: Английский

One-Pot Synthesis of Fe(III)-Curcumin Coordination Polymer Nanoparticles with Dynamic Disassembly and Elimination Abilities for Cancer Therapy DOI

Yue Cao,

Xin Zhang, Bo Ren

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Language: Английский

Citations

0
Nanoengineering of Phosphate/Phosphonate Drugs via Competitive Replacement with Metal‐Phenolic Networks to Overcome Breast Tumor with Lung and Bone Metastasis DOI Creative Commons

Wanrui Shi,

Dashuai Liu,

Wenjie Feng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 18, 2024

Abstract Phosphate and phosphonate drugs are vital in building organisms, regulating physiological processes, exhibiting diverse biological activities, including antiviral, antibacterial, antineoplastic, enzyme‐inhibitory effects. However, their therapeutic potential is limited by the lack of advanced nanoengineering technologies. Herein, a competitive coordination strategy for phosphate/phosphonate introduced. By leveraging difference capabilities between polyphenols phosphates/phosphonates with metal ions, various phosphate/phosphonate‐based nanodrugs using metal‐phenolic networks (MPNs) as templates agents constructed. The dynamic nature these bonds imparts stimuli‐responsiveness to nanodrugs, allowing targeted release therapy. As proof concept, Fe 3+ galangin used form MPN template, zoledronic acid cGAMP agents, DOX loaded drug construct DOX@Fe‐galangin@Fe‐zoledronic acid‐cGAMP nanodrugs. results demonstrate that, triggering pyroptosis activating cGAS‐STING pathway, exhibit potent cytotoxicity accurate selectivity eradicating orthotopic breast tumors, activate an antitumor immune response against lung bone metastases. Because applicable variety it holds significant enhancing clinical efficacy advancing nanodrug development complex applications.

Language: Английский

Citations

1