Hyperpolarized ¹²⁹Xe diffusion‐weighted MRI of the lung with 3D golden‐angle radial sampling and keyhole reconstruction

Medical Physics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Abstract Background Hyperpolarized (HP) 129 Xe multiple b ‐values diffusion‐weighted imaging (DWI) facilitates the assessment of pulmonary morphology. However, conventional DWI method, such as 2D GRE DWI, is limited in its application due to long acquisition time and relatively thick slice. Purpose To develop a method combining 3D golden‐angle radial sampling with keyhole reconstruction (GRSK) for accelerating obtaining thinner Methods For GRSK kooshball was used image acquisition, each spoke assigned 1 4 ‐values, applied reconstructing DW images under different ‐values. fully sampled were obtained five healthy young volunteers (HYV; 25 [24–26] years). Lung morphological parameter maps, including mean linear intercept (L m ) surface‐to‐volume ratio (SVR), generated using cylinder model (CM) from four images, apparent diffusion coefficient (ADC) maps derived through mono‐exponential fitting. Spearman correlation Bland‐Altman analysis performed compare L , SVR ADC DWI. In addition, emphysema patients (66 [60–69] years) age‐matched controls (AMC; 59 [54–68] years), also derived. Wilcoxon rank‐sum test utilized contrast those AMC. Results an isotropic resolution (5 mm) within 11.4 s. comparison, acquired slices 30 mm thickness 15.9 coefficients 0.975, 0.900, 1.000, corresponding p 0.005, 0.037, < 0.001, Bland–Altman had biases −3.19%, 1.44%, −3.71%, respectively. Furthermore, significantly higher ( = 0.008 0.008) than AMC, while notably reduced 0.008). Conclusion The proposed could obtain s breath‐hold duration, mitigating problems scan large slice

Language: Английский

Water-stable Metal-Organic Framework for Hyperpolarized Xenon MRI in Aqueous Solution

Chemical Research in Chinese Universities, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Language: Английский