Kelp and Cartilage Acellular Matrix Hybrid Microgel Assembly Realizes Articular Cartilage Repair Via ROS Scavenging, Endogenous BMSC Recruitment and Chondrogenic Differentiation DOI
Junlin Chen, Qingtao Li,

Chuhan Lv

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 27, 2025

Abstract Articular cartilage repair remains challenging due to the inherent poor self‐healing capacity and acute inflammation resulting from over expression of intracellular reactive oxygen species (ROS). Although microfracture is frequently used in practical surgery, newborn always exhibits fibrosis, mainly attributed weak ROS scavenging mismatched microenvironment that fails induce chondrogenic differentiation bone marrow mesenchymal stem cells (BMSCs). Herein, a novel simvastatin (SIM)‐incorporated kelp acellular matrix hybrid (labeled as SIM@KACM/CACM) microgel assembly with enhanced scavenging, endogenous BMSC recruitment, capabilities constructed improve microfracture‐based articular repair. The low immunogenicity, high biocompatibility, properties, whilst sustained SIM release promotes recruitment cavity. Meanwhile, bioactive factors conferred by CACM facilitate proliferation into hyaline cartilage. In addition, construction porous via dynamic Schiff's bonds endows excellent injectability tissue adhesion, which not only enhances its retention defect site after injection but also provides abundant sites for anchoring infiltration. Due synergetic effect above‐mentioned multiple factors, improved dramatically.

Language: Английский

Advances in locally administered nucleic acid therapeutics DOI
Jie Shen, Xiangfeng Duan, Ting Xie

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 218 - 254

Published: March 10, 2025

Language: Английский

Citations

0
Kelp and Cartilage Acellular Matrix Hybrid Microgel Assembly Realizes Articular Cartilage Repair Via ROS Scavenging, Endogenous BMSC Recruitment and Chondrogenic Differentiation DOI
Junlin Chen, Qingtao Li,

Chuhan Lv

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 27, 2025

Abstract Articular cartilage repair remains challenging due to the inherent poor self‐healing capacity and acute inflammation resulting from over expression of intracellular reactive oxygen species (ROS). Although microfracture is frequently used in practical surgery, newborn always exhibits fibrosis, mainly attributed weak ROS scavenging mismatched microenvironment that fails induce chondrogenic differentiation bone marrow mesenchymal stem cells (BMSCs). Herein, a novel simvastatin (SIM)‐incorporated kelp acellular matrix hybrid (labeled as SIM@KACM/CACM) microgel assembly with enhanced scavenging, endogenous BMSC recruitment, capabilities constructed improve microfracture‐based articular repair. The low immunogenicity, high biocompatibility, properties, whilst sustained SIM release promotes recruitment cavity. Meanwhile, bioactive factors conferred by CACM facilitate proliferation into hyaline cartilage. In addition, construction porous via dynamic Schiff's bonds endows excellent injectability tissue adhesion, which not only enhances its retention defect site after injection but also provides abundant sites for anchoring infiltration. Due synergetic effect above‐mentioned multiple factors, improved dramatically.

Language: Английский

Citations

0