Conjugated Polymer-Photosensitizers for Cancer Photodynamic Therapy and Their Multimodal Treatment Strategies DOI Open Access
Zhen Cheng,

Qianyi Ye,

Junpeng Lao

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(9), P. 1258 - 1258

Published: May 5, 2025

Conjugated polymers (CPs) have emerged as promising candidates for photodynamic therapy (PDT) in cancer treatment due to their high fluorescence quantum yield, excellent photostability, and remarkable reactive oxygen species (ROS) generation capability. This review systematically summarizes molecular design strategies augment CP photosensitivity efficiency, including: (1) constructing donor–acceptor (D-A) alternating structures, (2) incorporating aggregation-induced emission (AIE) moieties, (3) employing heavy-atom effects, (4) designing hyperbranched architectures. In addition, considering the limitations of monotherapy like tumor heterogeneity, we will further discuss synergistic CP-mediated PDT combination with other therapeutic modalities, including photothermal (PTT)-PDT, immunotherapy-PDT, chemotherapy-PDT, Chemiluminescence (CL)-PDT, diagnostic technology-PDT, chemodynamic (CDT)-PDT. These multimodal approaches leverage complementary mechanisms achieve enhanced eradication efficacy.

Language: Английский

Conjugated Polymer-Photosensitizers for Cancer Photodynamic Therapy and Their Multimodal Treatment Strategies DOI Open Access
Zhen Cheng,

Qianyi Ye,

Junpeng Lao

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(9), P. 1258 - 1258

Published: May 5, 2025

Conjugated polymers (CPs) have emerged as promising candidates for photodynamic therapy (PDT) in cancer treatment due to their high fluorescence quantum yield, excellent photostability, and remarkable reactive oxygen species (ROS) generation capability. This review systematically summarizes molecular design strategies augment CP photosensitivity efficiency, including: (1) constructing donor–acceptor (D-A) alternating structures, (2) incorporating aggregation-induced emission (AIE) moieties, (3) employing heavy-atom effects, (4) designing hyperbranched architectures. In addition, considering the limitations of monotherapy like tumor heterogeneity, we will further discuss synergistic CP-mediated PDT combination with other therapeutic modalities, including photothermal (PTT)-PDT, immunotherapy-PDT, chemotherapy-PDT, Chemiluminescence (CL)-PDT, diagnostic technology-PDT, chemodynamic (CDT)-PDT. These multimodal approaches leverage complementary mechanisms achieve enhanced eradication efficacy.

Language: Английский

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