Natural compounds targeting ferroptosis in ovarian cancer: research progress and application potential DOI Creative Commons

Yuanyuan Zhao,

Ling Lü, Xingying Chen

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107729 - 107729

Published: April 1, 2025

Ovarian cancer (OC) is among the most common malignancies in female reproductive system, marked by high rates of recurrence and mortality. Conventional chemotherapy, however, faces limitations due to development drug resistance, which hinders its effectiveness. Ferroptosis, an atypical form programmed cell death distinct from autophagy, apoptosis, necrosis, relationship with tumors has become a hot research area studies recent years. Anticancer therapies that target ferroptosis show strong potential improving prognosis counteracting chemotherapy resistance. Natural compounds, as valuable source novel targeted anticancer agents, significant role inhibiting tumor proliferation metastasis therapeutic sensitivity been demonstrated numerous existing studies. This review summarizes range natural compounds OC cells, discussing their active components, mechanisms action, potential, thereby providing useful insights for future therapy OC.

Language: Английский

Hypoxia-induced NDRG1 C-terminal Poly-phosphorylation Impairs its Tumor Suppressor Function in Renal Cell Carcinoma DOI

Qiang Guo,

Meiyu Quan,

Jingyu Zheng

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 619, P. 217659 - 217659

Published: March 24, 2025

Language: Английский

Citations

0
Natural compounds targeting ferroptosis in ovarian cancer: research progress and application potential DOI Creative Commons

Yuanyuan Zhao,

Ling Lü, Xingying Chen

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107729 - 107729

Published: April 1, 2025

Ovarian cancer (OC) is among the most common malignancies in female reproductive system, marked by high rates of recurrence and mortality. Conventional chemotherapy, however, faces limitations due to development drug resistance, which hinders its effectiveness. Ferroptosis, an atypical form programmed cell death distinct from autophagy, apoptosis, necrosis, relationship with tumors has become a hot research area studies recent years. Anticancer therapies that target ferroptosis show strong potential improving prognosis counteracting chemotherapy resistance. Natural compounds, as valuable source novel targeted anticancer agents, significant role inhibiting tumor proliferation metastasis therapeutic sensitivity been demonstrated numerous existing studies. This review summarizes range natural compounds OC cells, discussing their active components, mechanisms action, potential, thereby providing useful insights for future therapy OC.

Language: Английский

Citations

0