Rapid Synergistic Thrombolysis of Ischemic Stroke Guided by High-Resolution and High-Speed Photoacoustic Cerebrovascular Imaging DOI Creative Commons

Mengtao Han,

Zhiwei Xue,

Mengchen Yu

et al.

Photoacoustics, Journal Year: 2025, Volume and Issue: unknown, P. 100722 - 100722

Published: April 1, 2025

Thrombosis is the major cause of ischemic stroke and poses a serious health burden globally. Current thrombolytic strategies, such as systematic administration recombinant human tissue plasminogen activator (rt-PA), are challenged by limited thrombolysis efficiency due to low targeting ability short plasma half-life. Here, we report rapid synergistic strategy that integrates sonothrombolysis rt-PA mediated pharmacological achieve accurate efficient treatment stroke. The (PLPA@PFP) uses platelet-biomimetic membrane carrier deliver both perfluoropentane (PFP) rt-PA, prolonging half-life effectively accumulating at thrombus within 0.5 hours. Upon exposure focused ultrasound, PFP-based cavitation effects significantly enhance breakdown penetration, enabling sono/pharmacological in vitro vivo. High-resolution photoacoustic (PA) imaging provides direct assessment vascular reperfusion following therapeutic intervention murine model stroke, offering important guidance for clinical treatment.

Language: Английский

Rapid Synergistic Thrombolysis of Ischemic Stroke Guided by High-Resolution and High-Speed Photoacoustic Cerebrovascular Imaging DOI Creative Commons

Mengtao Han,

Zhiwei Xue,

Mengchen Yu

et al.

Photoacoustics, Journal Year: 2025, Volume and Issue: unknown, P. 100722 - 100722

Published: April 1, 2025

Thrombosis is the major cause of ischemic stroke and poses a serious health burden globally. Current thrombolytic strategies, such as systematic administration recombinant human tissue plasminogen activator (rt-PA), are challenged by limited thrombolysis efficiency due to low targeting ability short plasma half-life. Here, we report rapid synergistic strategy that integrates sonothrombolysis rt-PA mediated pharmacological achieve accurate efficient treatment stroke. The (PLPA@PFP) uses platelet-biomimetic membrane carrier deliver both perfluoropentane (PFP) rt-PA, prolonging half-life effectively accumulating at thrombus within 0.5 hours. Upon exposure focused ultrasound, PFP-based cavitation effects significantly enhance breakdown penetration, enabling sono/pharmacological in vitro vivo. High-resolution photoacoustic (PA) imaging provides direct assessment vascular reperfusion following therapeutic intervention murine model stroke, offering important guidance for clinical treatment.

Language: Английский

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