The inducible role of autophagy in cell death: emerging evidence and future perspectives DOI Creative Commons

Xiangliang Huang,

Hao Yan, Zhifei Xu

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 26, 2025

Autophagy is a lysosome-dependent degradation pathway for recycling intracellular materials and removing damaged organelles, it usually considered prosurvival process in response to stress stimuli. However, increasing evidence suggests that autophagy can also drive cell death context-dependent manner. The bulk of contents the accumulation autophagosomes are recognized as mechanisms induced by alone. other forms regulated (RCD) whose not related excessive autophagic vacuolization. Notably, few reviews address studies on transformation from RCD, underlying molecular still vague. This review aims summarize existing autophagy-mediated elucidate mechanism which initiates comprehensively understand role determining fate. highlights prodeath effect autophagy, distinct generally perceived cytoprotective role, its mainly associated with selective proteins or organelles essential survival direct involvement machinery death. Additionally, this need better manipulation activation inhibition different pathological contexts, depending clinical purpose.

Language: Английский

The inducible role of autophagy in cell death: emerging evidence and future perspectives DOI Creative Commons

Xiangliang Huang,

Hao Yan, Zhifei Xu

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 26, 2025

Autophagy is a lysosome-dependent degradation pathway for recycling intracellular materials and removing damaged organelles, it usually considered prosurvival process in response to stress stimuli. However, increasing evidence suggests that autophagy can also drive cell death context-dependent manner. The bulk of contents the accumulation autophagosomes are recognized as mechanisms induced by alone. other forms regulated (RCD) whose not related excessive autophagic vacuolization. Notably, few reviews address studies on transformation from RCD, underlying molecular still vague. This review aims summarize existing autophagy-mediated elucidate mechanism which initiates comprehensively understand role determining fate. highlights prodeath effect autophagy, distinct generally perceived cytoprotective role, its mainly associated with selective proteins or organelles essential survival direct involvement machinery death. Additionally, this need better manipulation activation inhibition different pathological contexts, depending clinical purpose.

Language: Английский

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