HOTAIR Participation in Glycolysis and Glutaminolysis Through Lactate and Glutamate Production in Colorectal Cancer

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 388 - 388

Published: March 6, 2025

Metabolic reprogramming plays a crucial role in cancer biology and the mechanisms underlying its regulation represent promising study area. In this regard, discovery of non-coding RNAs opened new regulatory landscape, which is early stages investigation. Using differential expression model HOTAIR, we evaluated level metabolic enzymes, as well metabolites produced by glycolysis glutaminolysis. Our results demonstrated effect HOTAIR on glutaminolysis enzymes colorectal cells. Specifically, through overexpression inhibition determined influence PFKFB4, PGK1, LDHA, SLC1A5, GLUD1, GOT1, had direct impact lactate glutamate production. These findings indicate that significant producing “oncometabolites” essential to maintaining bioenergetics biomass necessary for tumor cell survival regulating

Language: Английский

Lactylation in cancer progression and drug resistance

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: unknown, P. 101248 - 101248

Published: April 1, 2025

Language: Английский