Impact of Immuno-Nutrition on the Nutritional Status, Inflammatory Response and Clinical Outcome of Clinic-Admitted Mild-Intensity-COVID-19 Patients: A Pilot, Perspective-Concluding Study DOI Creative Commons

Martina Basilico,

Marialaura Scarcella, Emanuele Rinninella

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(10), P. 1070 - 1070

Published: Oct. 12, 2023

The SARS-CoV-2 pandemic has impacted our lives since early 2020. Both malnutrition and an overweight status significantly correlate with worse patient outcomes mortality. Immuno-nutrition (IN) shown promising results in the inflammatory bowel disease (IBD) clinical course extubation time mortality of patients admitted to intensive care units (ICUs). Thus, we wanted assess impact a standardized IN oral formula on COVID-19 mild-intensity clinic late 2021. We prospectively enrolled Internal Medicine Unit San Benedetto General Hospital. All had biochemical, anthropometric, HRCT chest scan, nutritional assessments at admission and, after immuno-nutrition administration, 15 days interval follow up. 52 consecutive (mean age 60.9 ± 5.4 years, 17 F, BMI 23.5 Kg/m2). main comorbidities were diabetes (20%, type 2: 90%), hyperuricemia (15%), hypertension (38%), chronic ischemic heart (12%), COPD (13%), anxiety (10%), depression (8%). Upon informed consent, 14 67.9 7 26.7 Kg/m2) accepted be administered IN. A moderate severe was present 59% patients; MNA test (4.4 0.7) phase angle (PA) values, suggestive malnutrition, 13% patients. After admission, recorded three deaths 68.9 4.1 3 27.5 An correlated exitus occurrence (r = 0.65). One death reported among IN-treated administration followed by significant decrease markers tendency higher than those non-treated prevented worsening PA vs. In this population, development markers.

Language: Английский

Gut Microbiota and Critically Ill Patients: Immunity and Its Modulation via Probiotics and Immunonutrition DOI Open Access
Ludovico Abenavoli, Emidio Scarpellini, Maria Rosaria Paravati

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3569 - 3569

Published: Aug. 13, 2023

Critically ill patients have a hyper-inflammatory response against various offending injuries that can result in tissue damage, organ failure, and fatal prognosis. The origin of this detrimental, uncontrolled inflammatory cascade be found also within our gut. In detail, one the main actors is gut microbiota with its imbalance, namely dysbiosis: learning about microbiota’s dysfunction pathophysiology frame critical crucial emerging importance management systemic syndrome (SIRS) multiple (MODS). Multiple pieces evidence indicate bacteria populate efficiently modulate immune response. Treatment pretreatment probiotics shown promising preliminary results to attenuate inflammation, especially postoperative infections ventilation performance. Finally, it how immunonutrition may exert possible impact on health status intensive care. Thus, manuscript reviews from literature composition, derangement critically patients, pathophysiological role, described opportunities arising modulation.

Language: Английский

Citations

11
Impact of underweight status on mortality in sepsis patients: a meta-analysis DOI Creative Commons

Jiaan Chen,

Fan Zhang, Liang Li

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 6, 2025

The evidence regarding the impact of underweight status on clinical outcomes in patients with sepsis are still scarce and controversial. We aimed at conducting a meta-analysis to evaluate potential associations between mortality rate among patients. A comprehensive electronic search was performed PubMed, Cochrane Library, Embase, Web Science databases. Odds ratios (ORs) or mean differences 95% confidence intervals (CIs) were calculated using RevMan 5.3. total 58,348 (normal weight group: 49,084 patients; 9,264 patients) from 23 studies included this meta-analysis. results indicated that in-hospital (OR, 1.28; CI, 1.21, 1.35; heterogeneity: I 2 = 21%, P 0.21), 28-day 1.54; 1.26, 1.88; 74%, < 0.0001) 1-year 1.78; 1.58, 2.00; 41%, 0.17) significantly higher than those normal However, there no significant difference length hospital stay intensive care unit normal-weight Underweight is associated increased sepsis. Physicians should pay more attention management https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=631417, identifier CRD42025631417.

Language: Английский

Citations

0
Effect of Immuno-Nutrition on Malnutrition, Inflammatory Response and Clinical Course of Semi-Critically Ill COVID-19 Patients: A Pilot Perspective Study DOI Open Access
Marialaura Scarcella, Emidio Scarpellini,

Sara Piergallini

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(5), P. 1250 - 1250

Published: March 2, 2023

The SARS-COV 2 pandemic has hit on our lives since early 2020. During different contagion waves, both malnutrition and overweight significantly correlated with patient mortality. Immune-nutrition (IN) shown promising results in the clinical course of pediatric inflammatory bowel disease (IBD) rate extubation mortality patients admitted to an intensive care unit (ICU). Thus, we wanted assess effects IN a semi-intensive COVID-19 Unit during fourth wave that occurred at end 2021. prospectively enrolled San Benedetto General hospital. All had biochemical, anthropometric, high-resolution tomography chest scan (HRCT) complete nutritional assessments time admission, after oral administration immune-nutrition formula, 15 days interval follow-up. 34 consecutive (age 70.3 ± 5.4 years, 6 F, BMI 27.0 0.5 kg/m2). Main comorbidities were diabetes (20%, type 90 %), hyperuricemia (15%), hypertension (38%), chronic ischemic heart (8 COPD (8%), anxiety syndrome (5%), depression (5%). 58% affected as moderately-to-severely overweight; mini assessment (MNA) score (4.8 0.7) phase angle (PA) values (3.8 0.5) suggestive present 15% patients, mainly history cancer. After upon recorded 3 deaths (mean age 75.7 5.1 26.3 0.7 kg/m2) 4 ICU. Following formula administration, markers decreased (p < 0.05) while PA did not worsen. These latter findings observed historical control group receive IN. Only one needed protein-rich administration. this population prevented development significant decrease markers.

Language: Английский

Citations

5
Inadequate energy and protein intake, underweight and malnutrition are associated with in‐hospital mortality among COVID‐19 rehabilitation patients during the omicron outbreak in Hong Kong DOI Creative Commons
Terry Ho Yan Ting,

Tiffany Hoi Man Lo,

Winnie Wing Tung Lo

et al.

Aging Medicine, Journal Year: 2022, Volume and Issue: 5(3), P. 204 - 210

Published: Aug. 23, 2022

Abstract Objective Malnourished COVID‐19 patients were prone to higher mortality and longer length of stay (LOS). This study aims investigate the malnutrition risk prevalence in how other nutritional indicators are related clinical outcomes a rehabilitation hospital. Methods A retrospective cross‐sectional involved 174 during phase. Malnutrition risk, indicators, mortality, LOS compared among different groups. Albumin, nutrition intake, body mass index (BMI) investigated for their effects on outcomes. Results The was 94.9%; those older risk. BMI, energy protein intakes decreased as increased. lower death group. high group severely underweight had 2.7 times 2.2 in‐hospital death, respectively. For subjects ≥75 years old, odds ratio 6.2 <75 old. Conclusion We observed 94.9% patients. Patients with chance death. These results reinforced importance management

Language: Английский

Citations

8
Epidemiology, clinical profiles, and prognostic value of COVID‐19‐related cutaneous manifestations in African populations: a rapid narrative review DOI Creative Commons
Peter Nyasulu, Jacques L. Tamuzi

International Journal of Dermatology, Journal Year: 2023, Volume and Issue: 63(1), P. 10 - 22

Published: Nov. 15, 2023

Abstract Background Skin manifestations’ true prognostic value, and clinical epidemiological pictures in SARS‐CoV‐2 infection African populations are poorly described understudied. More familiarity with COVID‐19 cutaneous manifestations may aid early diagnosis or guide prognosis. Methods In this literature review, we looked for potential studies published from December 2019 to March 2023 on lesions populations. Our key questions were focused the values of related COVID‐19. Results findings show that vary by country severity COVID‐19, primarily multisystem inflammatory syndrome (MIS). Significant differences also found between various dermatological lesions, MIS, erythema multiforme‐like, livedoid, vesicular, varicella‐like rashes, urticarial, maculopapular morbilliform chilblain‐like pernio‐like rashes. There 47.5% (115/242) MIS cases reported nine studies. revealed be diagnosed 2–7 days due onset rash. Advanced age, obesity, diabetes, cardiovascular disease, HIV, tuberculosis, asthma, atopic underweight, malnutrition, malignancy associated Conclusions COVID‐19‐related skin important as a driving force

Language: Английский

Citations

1
Malnutrition independently predicts mortality at 18 months in patients hospitalised for Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) DOI
Federico Ravaioli, Lucia Brodosi,

Giulio Agnelli

et al.

Clinical Nutrition ESPEN, Journal Year: 2024, Volume and Issue: 63, P. 736 - 747

Published: July 27, 2024

Language: Английский

Citations

0
Social Determinants of Maintaining Nutrition in Older Adults with Advanced Dementia DOI Creative Commons
Jean Woo

The journal of nutrition health & aging, Journal Year: 2023, Volume and Issue: 27(6), P. 430 - 431

Published: June 1, 2023

Dysphagia is recognised as part of the frailty syndrome, especially for those at end life. There a tension in management between need to optimize nutrition status oral frailty, and respecting wishes patients and/or family members form advance care planning directives regarding artificial hydration. Management will likely be influenced by many social determinants, rather than solely based on evidence from clinical research.

Language: Английский

Citations

0
Impact of Immuno-Nutrition on the Nutritional Status, Inflammatory Response and Clinical Outcome of Clinic-Admitted Mild-Intensity-COVID-19 Patients: A Pilot, Perspective-Concluding Study DOI Creative Commons

Martina Basilico,

Marialaura Scarcella, Emanuele Rinninella

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(10), P. 1070 - 1070

Published: Oct. 12, 2023

The SARS-CoV-2 pandemic has impacted our lives since early 2020. Both malnutrition and an overweight status significantly correlate with worse patient outcomes mortality. Immuno-nutrition (IN) shown promising results in the inflammatory bowel disease (IBD) clinical course extubation time mortality of patients admitted to intensive care units (ICUs). Thus, we wanted assess impact a standardized IN oral formula on COVID-19 mild-intensity clinic late 2021. We prospectively enrolled Internal Medicine Unit San Benedetto General Hospital. All had biochemical, anthropometric, HRCT chest scan, nutritional assessments at admission and, after immuno-nutrition administration, 15 days interval follow up. 52 consecutive (mean age 60.9 ± 5.4 years, 17 F, BMI 23.5 Kg/m2). main comorbidities were diabetes (20%, type 2: 90%), hyperuricemia (15%), hypertension (38%), chronic ischemic heart (12%), COPD (13%), anxiety (10%), depression (8%). Upon informed consent, 14 67.9 7 26.7 Kg/m2) accepted be administered IN. A moderate severe was present 59% patients; MNA test (4.4 0.7) phase angle (PA) values, suggestive malnutrition, 13% patients. After admission, recorded three deaths 68.9 4.1 3 27.5 An correlated exitus occurrence (r = 0.65). One death reported among IN-treated administration followed by significant decrease markers tendency higher than those non-treated prevented worsening PA vs. In this population, development markers.

Language: Английский

Citations

0