An auxiliary diagnostic approach based on traditional Chinese medicine constitutions for older patients with frailty DOI Creative Commons
Xuchao Gu, Xiaojun Wang, Yijing Yang

et al.

Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(6)

Published: Nov. 25, 2024

Abstract Introduction As global population ages, frailty has surfaced as a major public health challenge. Given the heterogeneity of in clinical presentation, it is imperative to develop personalised diagnostic and treatment strategies. The traditional Chinese medicine (TCM) constitution offers notable advantages discerning individual differences. This study aims elucidate association between TCM constitutions frailty, providing insights into application for management. Methods An observational was conducted at Huadong hospital from July 2022 November 2023. A total 241 older patients were recruited. Each patient underwent assessments status. Comprehensive data collection encompassed medical history, biochemical indicators, bone mineral density (BMD), body composition physical performance metrics. Plasma samples also collected detect levels inflammatory factors lymphogenesis‐related factors, including IL‐1β, TNF‐α, VEGF‐C, ANGPTL4 ACV‐A. Multi‐level statistical analysis used establish relationship with frailty. Results Amongst all participants, 54 individuals classified non‐frail, 90 pre‐frail 97 frail. Regression indicated that closely associated four imbalanced constitutions: Qi deficiency, phlegm dampness, blood stasis depression. Subsequent demonstrated deficiency decreased BMD, dampness elevated high‐density lipoprotein levels, Blood glucose depression both BMD low‐density levels. Furthermore, characterised by exhibited inferior handgrip strength, walking pace, lower limb strength higher compared those balanced constitution. Conclusion Frailty independently Personalised approaches based on may offer valuable directing

Language: Английский

An auxiliary diagnostic approach based on traditional Chinese medicine constitutions for older patients with frailty DOI Creative Commons
Xuchao Gu, Xiaojun Wang, Yijing Yang

et al.

Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(6)

Published: Nov. 25, 2024

Abstract Introduction As global population ages, frailty has surfaced as a major public health challenge. Given the heterogeneity of in clinical presentation, it is imperative to develop personalised diagnostic and treatment strategies. The traditional Chinese medicine (TCM) constitution offers notable advantages discerning individual differences. This study aims elucidate association between TCM constitutions frailty, providing insights into application for management. Methods An observational was conducted at Huadong hospital from July 2022 November 2023. A total 241 older patients were recruited. Each patient underwent assessments status. Comprehensive data collection encompassed medical history, biochemical indicators, bone mineral density (BMD), body composition physical performance metrics. Plasma samples also collected detect levels inflammatory factors lymphogenesis‐related factors, including IL‐1β, TNF‐α, VEGF‐C, ANGPTL4 ACV‐A. Multi‐level statistical analysis used establish relationship with frailty. Results Amongst all participants, 54 individuals classified non‐frail, 90 pre‐frail 97 frail. Regression indicated that closely associated four imbalanced constitutions: Qi deficiency, phlegm dampness, blood stasis depression. Subsequent demonstrated deficiency decreased BMD, dampness elevated high‐density lipoprotein levels, Blood glucose depression both BMD low‐density levels. Furthermore, characterised by exhibited inferior handgrip strength, walking pace, lower limb strength higher compared those balanced constitution. Conclusion Frailty independently Personalised approaches based on may offer valuable directing

Language: Английский

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