Diamagnetic Signature of Beta‐Amyloid (Aβ) and Tau (τ) Tangle Pathology in Alzheimer's Disease: A Review

Aging Medicine, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 1, 2025

ABSTRACT The complex interplay between diamagnetic and paramagnetic substances within the brain, particularly in context of Alzheimer's disease (AD), offers a rich landscape for investigation using advanced quantitative neuroimaging techniques. Although conventional approaches have focused on properties iron, emerging promising research has highlighted significance signatures associated with beta‐amyloid (Aβ) plaques Tau (τ) protein aggregates. Quantitative susceptibility mapping (QSM) is post‐processing technique that visualizes characterizes these subtle alterations brain border tissue composition, such as gray–white matter interface. Through voxel‐wise separation contributions sources, QSM enabled identification quantification Aβ τ aggregates, even presence iron. However, several challenges remain utilizing clinical applications. These include relatively small magnitude signal compared to need high‐resolution imaging sophisticated analysis techniques, standardization acquisition protocols. Further necessary refine optimize parameters, develop robust pipelines improve sensitivity specificity detecting nature As our understanding continues evolve, expected play pivotal role advancing knowledge AD other neurodegenerative diseases.

Language: Английский

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Modulating Mitochondrial Dynamics Preserves Cognitive Performance via Ameliorating Iron-Mediated Brain Toxicity in Iron-Overload Rats

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 993, P. 177379 - 177379

Published: Feb. 13, 2025

Language: Английский

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Aging-Associated Amyloid-β Plaques and Neuroinflammation in Bottlenose Dolphins (Tursiops truncatus) and Novel Cognitive Health-Supporting Roles of Pentadecanoic Acid (C15:0)

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3746 - 3746

Published: April 16, 2025

There is an urgent need to identify interventions that broadly target aging-related cognitive decline and progression Alzheimer’s disease (AD). Bottlenose dolphins (Tursiops truncatus) have histologic changes similar AD in humans, they also develop shared age-associated co-morbidities identified as risk factors for including type 2 diabetes, ferroptosis, iron overload, which can be driven by nutritional C15:0 deficiency. We hypothesized (1) would amyloid beta (Aβ) plaques neuroinflammation paralleled of humans relation age-related progression, quantitative concentration, brain region; (2) dose-dependent activities relevant protecting health. Quantitative immunohistochemistry staining was used assess 68 tissues from archived brains 19 Navy evaluate associations among region, sex, age group. Further, activities, using a third-party panel intended screen potential therapeutics, were evaluated. Similar had the highest Aβ plaque density variation hippocampus (90th percentile 4.95 plaques/mm2), where increased with (p = 0.05). All measured markers detected, concentrations activated microglia (CD68+) (0.46 ± 0.38 cells/mm2). inhibitor two targets, fatty acid amide hydrolase (FAAH) (IC50 2.5 µM, 89% maximum inhibition at 50 µM relative URB597) monoamine oxidase B (MAO-B) 19.4 70% R(-)-Deprenyl). These demonstrated efficacy against formation neuroinflammation, protection function hippocampus. findings suggest that, addition co-morbidities, may play distinct role supporting health, especially higher concentrations.

Language: Английский

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Current Evidence of Arterial Spin Labeling in Amyotrophic Lateral Sclerosis: A Systematic Review

Clinical Neurology and Neurosurgery, Journal Year: 2024, Volume and Issue: 249, P. 108691 - 108691

Published: Dec. 16, 2024

Language: Английский

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