Recapitulating essential pathophysiological characteristics in lung-on-a-chip for disease studies DOI Creative Commons
Yanning Zhang, Xuejiao Wang, Yaoqing Yang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 28, 2023

Lung diseases have become a significant challenge to public healthcare worldwide, which stresses the necessity of developing effective biological models for pathophysiological and pharmacological studies human respiratory system. In recent years, lung-on-a-chip has been extensively developed as potentially revolutionary model paradigm with high efficiency improved accuracy, bridging gap between cell culture preclinical trials. The advantages technology derive from its capabilities in establishing 3D multicellular architectures dynamic microphysiological environments. A critical issue development is utilizing such recapitulate essential components system effectively restoring physiological functions illustrating disease progress. Here we present review technology, highlighting various strategies capturing lung pathological characteristics. key characteristics lungs are examined, including airways, alveoli, alveolar septum. Accordingly, research capture analyzed. Recent pneumonia, cancer, asthma, chronic obstructive pulmonary disease, fibrosis based on surveyed. Finally, cross-disciplinary approaches proposed foster future technology.

Language: Английский

3D-printed microrobots from design to translation DOI Creative Commons
Sajjad Rahmani Dabbagh, Misagh Rezapour Sarabi, Mehmet Tugrul Birtek

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 5, 2022

Microrobots have attracted the attention of scientists owing to their unique features accomplish tasks in hard-to-reach sites human body. can be precisely actuated and maneuvered individually or a swarm for cargo delivery, sampling, surgery, imaging applications. In addition, microrobots found applications environmental sector (e.g., water treatment). Besides, recent advancements three-dimensional (3D) printers enabled high-resolution fabrication with faster design-production turnaround time users limited micromanufacturing skills. Here, latest end 3D printed are reviewed (ranging from biomedical applications) along brief discussion over feasible actuation methods on- off-board), practical printing technologies microrobot fabrication. as future perspective, we discussed potential advantages integration smart materials, conceivable benefits implementation artificial intelligence (AI), well physical (PI). Moreover, order facilitate bench-to-bedside translation microrobots, current challenges impeding clinical elaborated, including entry obstacles immune system attacks) cumbersome standard test procedures ensure biocompatibility.

Language: Английский

Citations

107
Machine Learning-Enabled Prediction of 3D-Printed Microneedle Features DOI Creative Commons
Misagh Rezapour Sarabi, M. Munzer Alseed, Ahmet Agah Karagoz

et al.

Biosensors, Journal Year: 2022, Volume and Issue: 12(7), P. 491 - 491

Published: July 6, 2022

Microneedles (MNs) introduced a novel injection alternative to conventional needles, offering decreased administration pain and phobia along with more efficient transdermal intradermal drug delivery/sample collecting. 3D printing methods have emerged in the field of MNs for their time- cost-efficient manufacturing. Tuning parameters artificial intelligence (AI), including machine learning (ML) deep (DL), is an emerging multidisciplinary optimization manufacturing biomedical devices. Herein, we presented AI framework assess predict 3D-printed MN features. Biodegradable were fabricated using fused deposition modeling (FDM) technology followed by chemical etching enhance geometrical precision. DL was used quality control anomaly detection MNAs. Ten different designs various exposure doses create data library train ML models extraction similarity metrics order new fabrication outcomes when mentioned adjusted. The integration AI-enabled prediction printed will facilitate development healthcare systems advancement MNs' applications.

Language: Английский

Citations

56
Machine learning-enabled optimization of extrusion-based 3D printing DOI
Sajjad Rahmani Dabbagh, Oğuzhan Özcan, Savaş Taşoğlu

et al.

Methods, Journal Year: 2022, Volume and Issue: 206, P. 27 - 40

Published: Aug. 11, 2022

Language: Английский

Citations

41
Polymeric and biological membranes for organ-on-a-chip devices DOI Creative Commons
Kendra Corral-Nájera, Gaurav Chauhan, Sergio O. Serna‐Saldívar

et al.

Microsystems & Nanoengineering, Journal Year: 2023, Volume and Issue: 9(1)

Published: Aug. 29, 2023

Membranes are fundamental elements within organ-on-a-chip (OOC) platforms, as they provide adherent cells with support, allow nutrients (and other relevant molecules) to permeate/exchange through membrane pores, and enable the delivery of mechanical or chemical stimuli. Through OOC physiological processes can be studied in vitro, whereas membranes broaden knowledge how cues affect organs. OOCs vitro microfluidic models that used replace animal testing for various applications, such drug discovery disease modeling. In this review, relevance is discussed well their scaffold actuation roles, properties (physical material), fabrication methods different organ models. The purpose was aid readers selection development specific applications fields mechanistic, pathological, studies. Mechanical stimulation from liquid flow cyclic strain, effects on cell's increased (IPR), described first section. review also contains fabricate synthetic ECM (extracellular matrix) protein membranes, characteristics (e.g., thickness porosity, which adjusted depending application, shown graphical abstract), biological materials coatings. discussion section joins describes roles research purposes advantages challenges.

Language: Английский

Citations

25
AI-Based Metamaterial Design DOI Creative Commons
Ece Tezsezen, Defne Yigci, Abdollah Ahmadpour

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(23), P. 29547 - 29569

Published: May 29, 2024

The use of metamaterials in various devices has revolutionized applications optics, healthcare, acoustics, and power systems. Advancements these fields demand novel or superior that can demonstrate targeted control electromagnetic, mechanical, thermal properties matter. Traditional design systems methods often require manual manipulations which is time-consuming resource intensive. integration artificial intelligence (AI) optimizing metamaterial be employed to explore variant disciplines address bottlenecks design. AI-based also enable the development by parameters cannot achieved using traditional methods. application AI leveraged accelerate analysis vast data sets as well better utilize limited via generative models. This review covers transformative impact for current challenges, emerging fields, future directions, within each domain are discussed.

Language: Английский

Citations

16
Recent advances in 3D-printing-based organ-on-a-chip DOI Creative Commons

Xinkun Wu,

Wenwan Shi,

Xiaojiang Liu

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 100003 - 100003

Published: March 21, 2024

Organ-on-a-chip (OOC) facilitates precise manipulation of fluids in microfluidic chips and simulation the physiological, chemical, mechanical characteristics tissues, thus providing a promising tool for vitro drug screening physiological modeling. In recent decades, this technology has advanced rapidly because development various three-dimensional (3D) printing techniques. 3D can not only fabricate using materials such as resins polydimethylsiloxane but also construct biomimetic tissues bioinks cell-loaded hydrogels. review, advances 3D-printing-based OOC are systematically summarized based on used direct or indirect OOC, techniques construction applications models heart, blood vessels, intestines, liver, kidney. addition, future perspectives challenges area envisioned to inspire researchers employ accelerate development.

Language: Английский

Citations

12
Recent advances in Organ-on-a-Chip models: How precision engineering integrates cutting edge technologies in fabrication and characterization DOI
Sorour Sadeghzade, Mohammad Hosseini Hooshiar, Hossein Akbari

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 38, P. 102231 - 102231

Published: May 14, 2024

Language: Английский

Citations

9
Progress in Organ Bioprinting for Regenerative Medicine—Article DOI Creative Commons
X. Sheldon Wang, Di Zhang, Yogendra Pratap Singh

et al.

Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Organ damage or failure arising from injury, disease, and aging poses challenges due to the body's limited regenerative capabilities. transplantation presents issues of donor shortages immune rejection risks, necessitating innovative solutions. The 3D bioprinting organs on demand offers promise in tissue engineering medicine. In this review, we explore state-of-the-art technologies, with a focus bioink cell type selections. We follow discussions advances solid organs, such as heart, liver, kidney, pancreas, highlighting importance vascularization integration. Finally, provide insights into key future directions context clinical translation bioprinted their large-scale production.

Language: Английский

Citations

9
3D-Printed Microneedles for Point-of-Care Biosensing Applications DOI Creative Commons
Misagh Rezapour Sarabi, Sattar Akbari Nakhjavani, Savaş Taşoğlu

et al.

Micromachines, Journal Year: 2022, Volume and Issue: 13(7), P. 1099 - 1099

Published: July 13, 2022

Microneedles (MNs) are an emerging technology for user-friendly and minimally invasive injection, offering less pain lower tissue damage in comparison to conventional needles. With their ability extract body fluids, MNs among the convenient candidates developing biosensing setups, where target molecules/biomarkers detected by biosensor using sample collected with MNs. Herein, we discuss 3D printing of microneedle arrays (MNAs) toward enabling point-of-care (POC) applications.

Language: Английский

Citations

35
Point‐of‐Care Diagnostic Platforms for Loop‐Mediated Isothermal Amplification DOI Creative Commons
Nazente Atçeken, M. Munzer Alseed, Sajjad Rahmani Dabbagh

et al.

Advanced Engineering Materials, Journal Year: 2022, Volume and Issue: 25(8)

Published: Nov. 27, 2022

The loop‐mediated isothermal amplification (LAMP) method is one of the Nucleic acid tests (NAATs) that allows for target regions without using a thermal cycle. With its unique primer design, LAMP ensures rapid replication targeted DNA region with high specificity and efficiency. technology used diagnostic purposes in pathogen detection due to ease use, low cost, simplicity requiring complex equipment. A wide range platforms have been developed applications bacteria, virus, parasitic detection. Herein, methodology SNP genotyping mutation are discussed. Point‐of‐care (PoC) designed principles microfluidic chip technology, including LAMP‐on‐a‐chip, paper‐based LAMP, smartphone‐based elaborated. represents fast, robust, reliable platform point‐of‐care testing.

Language: Английский

Citations

30