Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(32)
Published: Oct. 14, 2024
Abstract
Chronic
wounds
are
characterized
by
long‐term
inflammation,
including
diabetic
ulcers,
traumatic
etc.,
which
provide
an
optimal
environment
for
bacterial
proliferation.
At
present,
antibiotics
the
main
clinical
treatment
method
chronic
wound
infections.
However,
overuse
of
may
accelerate
emergence
drug‐resistant
bacteria,
poses
a
significant
threat
to
human
health.
Therefore,
there
is
urgent
need
develop
new
therapeutic
strategies
Nanozyme‐based
antimicrobial
therapy
(NABT)
emerging
strategy
with
broad‐spectrum
activity
and
low
drug
resistance
compared
traditional
antibiotics.
NABT
has
shown
great
potential
as
catalyzing
generation
reactive
oxygen
species
(ROS)
its
enzyme‐like
catalytic
properties,
producing
powerful
bactericidal
effect
without
developing
resistance.
cascade
technology
offers
approach
infection
control,
effectively
improving
efficacy
activating
cascades
against
cell
membranes
intracellular
DNA
while
minimizing
side
effects.
it
worth
noting
that
this
still
in
early
stages
research.
This
article
comprehensively
reviews
classification,
current
methods
infection,
different
types
nanozymes,
application
nanozyme
reaction
therapy,
future
challenges
prospects.
Journal of drug targeting,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 27
Published: Nov. 1, 2024
Since
its
emergence
shortly
after
the
discovery
of
penicillin,
antibiotic
resistance
has
escalated
dramatically,
posing
a
significant
health
threat
and
economic
burden.
Combating
resistance,
especially
in
Gram-negative
bacteria
(GNB)
drug-resistant
Mycobacterium
tuberculosis,
necessitates
innovative
research,
substantial
financial
investment,
global
cooperation
to
safeguard
public
develop
sustainable
solutions.
Drug
repositioning,
or
drug
repurposing,
involves
identifying
new
therapeutic
applications
for
existing
drugs,
utilizing
their
established
safety
profiles
pharmacological
data
swiftly
provide
effective
treatments
against
resistant
pathogens.
Several
including
otilonium
bromide,
penfluridol,
eltrombopag,
ibuprofen,
ceritinib,
have
demonstrated
potent
antibacterial
activity
multidrug-resistant
(MDR)
bacteria.
These
drugs
can
disrupt
biofilms,
damage
bacterial
membranes,
inhibit
growth.
Furthermore,
combination
repurposed
with
conventional
antibiotics
reduce
required
dosage
individual
mitigate
side
effects,
delay
development
making
it
promising
strategy
MDR
such
as
Staphylococcus
aureus,
Klebsiella
pneumoniae,
Pseudomonas
aeruginosa,
Escherichia
coli.
Despite
promise,
repurposing
faces
challenges
potential
off-target
toxicity,
regulatory
intellectual
property
issues,
necessitating
rigorous
evaluations
strategic
This
article
aims
explore
combat
examining
benefits,
challenges,
future
prospects.
We
address
legal,
economic,
practical
associated
highlight
successful
examples,
propose
solutions
enhance
efficacy
viability
this
approach
combating
infections.
Fundamental Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 1, 2024
Osteoarthritis
(OA)
is
a
common
degenerative
disease
with
high
disability
rate,
imposing
significant
economic
burdens
on
individuals
and
society.
Due
to
the
limited
self-repair
ability
of
articular
cartilage,
existing
treatment
methods
still
cannot
effectively
treat
OA.
Organoids
are
multicellular
structures
differentiated
from
stem
cells
or
organ
progenitors
can
be
used
model
disease.
Future
applications
provide
alternative
replacement
strategies.
Therefore,
constructing
cartilage
organoids
expected
overcome
shortcomings
achieve
effective
The
construction
requires
three-dimensional
network
scaffolds
resembling
extracellular
matrix
(ECM)
support
cell
expansion.
Hydrogel
has
hydrophilic
natural
structure.
Hence
it
mimic
ECM,
providing
mechanical
favorable
microenvironment
for
growth.
DNA
hydrogel
mainly
formed
by
DNA.
It
preserves
DNA's
programmability,
biocompatibility
biodegradability,
unique
properties.
Thus,
an
ideal
material
organoids.
This
review
summarized
preparation
discussed
use
hydrogels
in
organoids,
aiming
reference
design
based
hydrogels.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(32)
Published: Oct. 14, 2024
Abstract
Chronic
wounds
are
characterized
by
long‐term
inflammation,
including
diabetic
ulcers,
traumatic
etc.,
which
provide
an
optimal
environment
for
bacterial
proliferation.
At
present,
antibiotics
the
main
clinical
treatment
method
chronic
wound
infections.
However,
overuse
of
may
accelerate
emergence
drug‐resistant
bacteria,
poses
a
significant
threat
to
human
health.
Therefore,
there
is
urgent
need
develop
new
therapeutic
strategies
Nanozyme‐based
antimicrobial
therapy
(NABT)
emerging
strategy
with
broad‐spectrum
activity
and
low
drug
resistance
compared
traditional
antibiotics.
NABT
has
shown
great
potential
as
catalyzing
generation
reactive
oxygen
species
(ROS)
its
enzyme‐like
catalytic
properties,
producing
powerful
bactericidal
effect
without
developing
resistance.
cascade
technology
offers
approach
infection
control,
effectively
improving
efficacy
activating
cascades
against
cell
membranes
intracellular
DNA
while
minimizing
side
effects.
it
worth
noting
that
this
still
in
early
stages
research.
This
article
comprehensively
reviews
classification,
current
methods
infection,
different
types
nanozymes,
application
nanozyme
reaction
therapy,
future
challenges
prospects.
