Targeting the gut and tumor microbiome in cancer resistance DOI
Sona Ciernikova, Aneta Sevcikova, Michal Mego

et al.

AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 327(6), P. C1433 - C1450

Published: Oct. 22, 2024

Therapy resistance represents a significant challenge in oncology, occurring various therapeutic approaches. Recently, animal models and an increasing set of clinical trials highlight the crucial impact gut tumor microbiome on treatment response. The intestinal contributes to cancer initiation, progression, formation distant metastasis. In addition, tumor-associated microbiota is considered critical player influencing microenvironments regulating local immune processes. Intriguingly, numerous studies have successfully identified pathogens within that might be linked poor response different modalities. unfavorable microbial composition with presence specific microbes participates progression via several mechanisms, including upregulation oncogenic pathways, macrophage polarization reprogramming, metabolism chemotherapeutic compounds, autophagy pathway modulation, enhanced DNA damage repair, inactivation proapoptotic cascade, bacterial secretion extracellular vesicles, promoting processes metastatic cascade. Targeted elimination intratumoral bacteria appears enhance However, broad-spectrum antibiotic pretreatment mostly connected reduced efficacy due dysbiosis lower diversity. Mounting evidence supports potential modulation by probiotics fecal transplantation improve increase diversity, leading while mitigating adverse effects. this context, further research concerning identification clinically relevant signatures followed microbiota-targeted strategies presents promising approach overcoming immunotherapy chemotherapy refractory patients, improving their outcomes.

Language: Английский

Enhancing Fractionated Cancer Therapy: A Triple-Anthracene Photosensitizer Unleashes Long-Persistent Photodynamic and Luminous Efficacy DOI
Youjuan Wang,

Hengxin Shen,

Zhe Li

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(9), P. 6252 - 6265

Published: Feb. 20, 2024

Conventional photodynamic therapy (PDT) is often limited in treating solid tumors due to hypoxic conditions that impede the generation of reactive oxygen species (ROS), which are critical for therapeutic efficacy. To address this issue, a fractionated PDT protocol has been suggested, wherein light irradiation administered stages separated by dark intervals permit recovery during these breaks. However, current photosensitizers used incapable sustaining ROS production intervals, leading suboptimal outcomes (Table S1). circumvent drawback, we have synthesized novel photosensitizer based on triple-anthracene derivative designed prolonged generation, even after cessation exposure. Our study reveals unique action derivatives, facilitating direct and effective disruption biomolecules significantly improving efficacy S2). Moreover, existing lack imaging capabilities monitoring, constraints fine-tuning parameters also serves as an afterglow agent, emitting sustained luminescence postirradiation. This function allows precise optimization between sessions aids determining timing subsequent irradiation, thus enabling meticulous control over parameters. Utilizing our photosensitizer, formulated regimen effectively eliminates orthotopic pancreatic tumors. investigation highlights promise employing long-persistent activity advanced approaches overcome limitations tumor treatment.

Language: Английский

Citations

35
Intratumoral Microbiota as a Target for Advanced Cancer Therapeutics DOI
Fei Peng, Mengyuan Hu, Zhiyue Su

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)

Published: July 26, 2024

Abstract In recent years, advancements in microbial sequencing technology have sparked an increasing interest the bacteria residing within solid tumors and its distribution functions various tumors. Intratumoral critically modulate tumor oncogenesis development through DNA damage induction, chronic inflammation, epigenetic alterations, metabolic immune regulation, while also influencing cancer treatment efficacy by affecting drug metabolism. response to these discoveries, a variety of anti‐cancer therapies targeting microorganisms emerged. These approaches encompass oncolytic therapy utilizing tumor‐associated bacteria, design biomaterials based on intratumoral use bacterial components for delivery systems, comprehensive strategies aimed at eradication tumor‐promoting bacteria. Herein, this review article summarizes patterns different tumors, examines their impact evaluates current therapeutic centered Furthermore, challenges prospects developing drugs that target communities are explored, promising new directions treatment.

Language: Английский

Citations

9
Top‐Down Assembly of Photosensitizable Flexible Wood Dressing with Synergistic Effect of Anti‐Infection and Moisture Management DOI Open Access
Siqi Huang, Zaiyu Wang, Qian Wu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Infected wound repair stands as a formidable global issue, posing significant threats to public health and medical care. Biopolymer‐based dressings represent natural biocompatible candidate greatly conductive healing. However, the low productivity high price, coupled with widespread lack of antibacterial activities, vitally restrict their clinical applications. Herein, simple yet efficient top‐down assembly strategy is reported fabricate aggregation‐induced emission photosensitizer (AIE‐PS) functionalized flexible wood (AIE/FW) dressing synergistic photodynamic therapy moisture management accelerate healing infected wounds. On account its superior bactericidal effectiveness appropriate management, along superb flexibility excellent biocompatibility, proposed AIE/FW can effectively prevent infection alleviate inflammatory response, thereby dramatically boosting recovery. It anticipated that scalable, sustainable, cost‐effective offers promising pathway overcome care challenges.

Language: Английский

Citations

1
Advances in Engineered Phages for Disease Treatment DOI Open Access
Xiaolin Hou,

Zhai Lin,

Laiying Fu

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Abstract Phage therapy presents a promising solution for combating multidrug‐resistant (MDR) bacterial infections and other bacteria‐related diseases, attributed to their innate ability target lyse bacteria. Recent clinical successes, particularly in treating MDR‐related respiratory post‐surgical infections, validated the therapeutic potential of phage therapy. However, complex microenvironment within human body poses significant challenges activity efficacy vivo. To overcome these barriers, recent advances engineering have aimed enhance targeting accuracy, improve stability survivability, explore synergistic combinations with modalities. This review provides comprehensive overview therapy, emphasizing application engineered phages antibacterial tumor vaccine development. Furthermore, highlights current future trends advancing toward broader applications.

Language: Английский

Citations

1
Advancing Targeted Therapies in Pancreatic Cancer: Leveraging Molecular Aberrations for Therapeutic Success DOI
Tanvi Gupta, Mohd Murtaza

Progress in Biophysics and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Photodynamic inactivation of Listeria monocytogenes using a natural aggregation-induced emission photosensitizer and its application in salmon preservation DOI Creative Commons
Qianying Li,

Baichuan Wang,

Shiyu Peng

et al.

LWT, Journal Year: 2024, Volume and Issue: 193, P. 115762 - 115762

Published: Jan. 16, 2024

Photodynamic sterilization has been regarded as a promising alternative to conventional antibacterial approaches. However, the photodynamic efficiency of photosensitizer is often compromised by aggregation-induced quenching effects. Photosensitizers, especially natural products, with emission (AIE) properties open new avenue for sterilization. Herein, we investigated performance and mechanism AIE-type product berberine (BBR) against Listeria monocytogenes (L. monocytogenes). The bactericidal effect was assessed through determination minimum concentration implementation anti-biofilm experiments. results showed that BBR can significantly suppress proliferation L. efficiently remove monocytogenes-derived biofilm in concentration-dependent trend. killing speculated based on bacterial morphology characterization, viability staining results, enzyme activity assays, DNA electrophoresis analysis, molecular docking. excellent anti-bacterial mediated process may account its abilities irreversibly disruption membrane, inhibition intracellular decomposition molecules. We also demonstrated embedded sodium alginate/chitosan packaging film feasible maintain freshness salmon under light illumination inhibiting proliferation.

Language: Английский

Citations

6
Recent progress in nanomaterials for bacteria-related tumor therapy DOI
Fuping Zhang, Shuyu Wang, Shuo Yang

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(8), P. 1965 - 1980

Published: Jan. 1, 2024

Recent progress in nanomaterials for bacteria-related tumor therapy terms of chemotherapy, immunotherapy and synergistic is summarized this review order to provide some insights into emerging rapidly growing research area.

Language: Английский

Citations

4
Recent progress on drug delivery systems of regulating intratumoral bacteria for tumor therapy DOI
Jing Feng, Yanhong Liu, Liming Gong

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110907 - 110907

Published: Feb. 1, 2025

Language: Английский

Citations

0
Dual Cascade‐Responsive Multifunctional Nanoparticles to Overcome Bacterium‐Induced Drug Inactivation and Enhanced Photodynamic and Chemo‐Immunotherapy of Pancreatic Cancer DOI Open Access
Maolin Li, Tong Li, Yin Liu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract The harsh biological barriers and bacteria within tumor microenvironment not only hinder drug penetration induce inactivation, but also inhibit antitumor immune responses. Here a dual cascade‐responsive multifunctional nanoparticle, Gem/Emo@NP@GHA is reported, which engineered from hyaluronidase (HAase)‐responsive guanidine group functionalized hyaluronic acid (GHA) shell glutathione (GSH)‐responsive biopolymer core (Gem/Emo@NP), that encapsulates anticancer gemcitabine (Gem) two‐photon‐excited photosensitizer emodin (Emo). constructed can specifically target the subsequently be degraded by HAase‐abundant in extracellular matrix. Thus, resulting Gem/Emo@NP achieved size reduction charge reversal, strengthening deep penetration. Upon internalization, positively charged effectively kills intratumor inducing membrane depolarization. Furthermore, high levels of GSH cells disrupt disulfide bonds Gem/Emo@NP, triggering release. Thereby, undecomposed Gem successfully induces cell apoptosis necrosis. Under laser irradiation, Emo generates singlet oxygen ( 1 O 2 ), further eliminating tumors intracellular bacteria. More importantly, activate T cell‐mediated response, enhancing activity. These findings provide promising approach to treating bacterially infected through synergistic application chem‐immunotherapy photodynamic therapy.

Language: Английский

Citations

0
Biomimetic Cancer-Targeting Nanoplatform Boosting AIEgens-Based Photodynamic Therapy and Ferroptosis by Disrupting Redox-Homeostasis DOI
Yu Wan, Yifei Cao,

Dandan Hu

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(6), P. 3813 - 3824

Published: May 23, 2024

Photodynamic therapy (PDT) using aggregation-induced emission photosensitizer (AIE-PS) holds tremendous potential but is limited by its inherent disadvantages and the high concentrations of reduced glutathione (GSH) in tumor cells that can neutralize ROS to weaken PDT. Herein, we designed a nanodelivery system (CM-HSADSP@[PS-Sor]) which albumin was utilized as carrier for hydrophobic drug AIE-PS Sorafenib, cross-linkers with disulfide bonds were introduced form nanogel core, then cancer cell membranes wrapped on surface confer homologous targeting ability. A two-way strategy employed disturb redox-homeostasis through blocking GSH synthesis Sorafenib consuming excess via abundant bonds, thereby promoting depletion GSH, turn increased levels amplify efficacy ferroptosis PDT, achieving an efficient vivo antibreast effect. This study brings new ROS-based expands application albumin-based delivery system.

Language: Английский

Citations

3