“Dandelion” magnetic bead-driven CDs@CeO2 based-multifunctional nanoplatform for tri-modal ultrasensitive detection and efficient eradication of pathogenic bacteria

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 424, P. 136903 - 136903

Published: Nov. 5, 2024

Language: Английский

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Photodynamic therapy combined with quaternized chitosan antibacterial strategy for instant and prolonged bacterial infection treatment

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 352, P. 123147 - 123147

Published: Dec. 13, 2024

Language: Английский

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Self-assembled copper-based nanoparticles for enzyme catalysis-enhanced chemodynamic/photodynamic/antiangiogenic tritherapy against hepatocellular carcinoma

Published: Feb. 19, 2024

Abstract As an emerging cancer treatment strategy, reactive oxygen species-based tumor catalytic therapies face enormous challenges due to hypoxia and overexpression of glutathione (GSH) in the microenvironment. Herein, a self-assembled copper-based nanoplatform, TCCHA, was designed for enzyme-like catalysis-enhanced chemodynamic/photodynamic/antiangiogenic tritherapy against hepatocellular carcinoma. TCCHA fabricated from Cu 2+ , 3,3′-dithiobis (propionohydrazide), photosensitizer chlorine e6 via facile one-pot self-assembly after which aldehyde hyaluronic acid coated, followed by loading antivascular drug AL3818. The obtained nanoparticles exhibited pH/GSH dual-responsive release behaviors multienzymatic activities, including Fenton, peroxidase-, catalase-like activities. redox homeostasis disruptor, promotes ⋅OH generation GSH depletion, thus increasing efficacy chemodynamic therapy. has activity, can also reinforce photodynamic therapy amplifying O 2 production. In vivo, efficiently inhibited angiogenesis suppressed growth without apparent systemic toxicity. Overall, this study presents strategy preparation multienzyme-like nanoparticles, display great potential enzyme triple cancer.

Language: Английский

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Engineered Platelets for Cancer Therapy

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

ABSTRACT While nanomedicine research shows a great progress in the treatment of cancer, it still faces challenges tumor recurrence and metastasis. Numerous studies have demonstrated intricate crosstalk between platelets cells. The re‐education by cells enables these to provide critical assistance for proliferation, recurrence, Engineered shown promising potential tumors, postoperative Different engineering technologies such as surface modification, gene editing, membrane coating, loading into hydrogels can produce multifunctional customized engineered platelets. These inherit key properties platelets, including long blood circulation, targeting, thrombus be stimulated generate derivatized particles. In this review, we elucidate role complex processes tumorigenesis progression summarize emerging paradigm therapy. purpose review is comprehensively explore value toward clinical providing valuable reference further development their broader applications field cancer

Language: Английский

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Peptide core spherical nucleic acids circumvent tumor immunosuppression via supplementing methionine for enhanced photodynamic/gene immune/therapy of hepatocellular carcinoma

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 682, P. 653 - 670

Published: Nov. 29, 2024

Language: Английский

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