Aggregation-Induced Emission: Application in Diagnosis and Therapy of Hepatocellular Carcinoma DOI

Wenjing Xu,

Danfeng Jian,

Yang Huang

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 266, P. 116722 - 116722

Published: Aug. 29, 2024

Language: Английский

Fluorescence-guided Surgery for Hepatocellular Carcinoma: From Clinical Practice to Laboratories DOI Open Access

Tian Xiao,

Didi Chen, Peng Li

et al.

Journal of Clinical and Translational Hepatology, Journal Year: 2025, Volume and Issue: 000(000), P. 000 - 000

Published: Jan. 2, 2025

Fluorescence navigation is a novel technique for accurately identifying hepatocellular carcinoma (HCC) lesions during hepatectomy, enabling real-time visualization. Indocyanine green-based fluorescence guidance has been commonly used to demarcate HCC lesion boundaries, but it cannot distinguish between benign and malignant liver tumors. This review focused on the clinical applications limitations of indocyanine green, as well recent advances in fluorescent probes fluorescence-guided surgery HCC. It covers traditional imaging such enzymes, reactive oxygen species, sulfur pH-sensitive probes, followed by an introduction aggregation-induced emission probes. Aggregation-induced exhibit strong fluorescence, low background signals, excellent biocompatibility, high photostability aggregate state, show no dilute solutions. Design strategies these may offer insights developing identification surgery.

Language: Английский

Citations

0
Zero-Crosstalk Tumor-Targeting Ratiometric Near-Infrared γ-Glutamyltranspeptidase Probe for Fluorescent-Guided Surgical Resection of Orthotopic Hepatic Tumor DOI
Zhichao Yang,

ZhiHao Yang,

Zhiqiang Wang

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

The challenge of "false positive" signals significantly complicates tumor localization and surgical resection, which are pivotal for successful surgeries. Therefore, the development a method preoperative intraoperative margin determination holds considerable promise improving outcomes. In this study, zero-crosstalk ratiometric tumor-targeting near-infrared (NIR) fluorescent probe was developed precise cancer diagnosis navigation via NIR fluorescence imaging. This integrates moiety that selectively homes in on hepatocellular carcinoma cells exhibits highly sensitive response to γ-glutamyltranspeptidase (GGT), characterized by substantial emission shift from 830 650 nm. unique property enhances its effectiveness early imaging-guided surgery resection. Furthermore, successfully monitors GGT activity blood, cells, vivo, endowing potential clinic. Due efficient targeting situ both subcutaneous tumors orthotopic hepatic tumors, accurate detection capability tumors. Additionally, leveraging imaging, can serve as sprayable tool delineating margins with precision, thereby furnishing real-time imaging guidance during resection surgery.

Language: Английский

Citations

0
Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy DOI
Zhen Liu, Wei Hu, Yingying Cai

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 690, P. 137332 - 137332

Published: March 14, 2025

Language: Английский

Citations

0
Sensitive discrimination of hazardous explosives by a sensor array based on siloles with aggregate-induced emission DOI

Hongbin Zhou,

Shengwen Yang, Fei Chen

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126386 - 126386

Published: May 1, 2025

Language: Английский

Citations

0
Safe transportation and targeted destruction: Albumin encapsulated aggregation‐induced emission photosensitizer nanoaggregate for tumor photodynamic therapy through mitochondria damage‐triggered pyroptosis DOI Creative Commons
Juanmei Cao, Yong Qu, Shaojie Zhu

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Abstract Photodynamic therapy is a highly recommended alternative treatment for solid tumors, such as cutaneous or luminal in clinical practice. However, conventional photosensitizers (PSs) often induce undesirable phototoxic effects because of their normal tissue distribution and reduction antitumor resulting from aggregation‐caused quenching effects. The present study developed novel nano‐formulated aggregation‐induced emission (AIE)‐characteristic PS, nab‐TTVPHE, which composed human serum albumin carrier TTVPHE therapeutic agent, more effective cancer with lower Notably, the reactive oxygen species generated by were shielded nanoaggregate structure, photodynamic activity was after nanostructure dissociation. Nab‐TTVPHE actively internalized tumor cells via secreted protein, acidic rich cysteine released to form nanoaggregates. accumulated mitochondria, where it triggered mitochondrial damage under light irradiation its induced pyroptosis caspase‐3/gasdermin E (GSDME) signaling pathway kill cells. Therefore, this AIE‐characteristic PS provides an innovative strategy effect ability boost potential immunity GSDME‐mediated pyroptosis.

Language: Английский

Citations

3
A novel AIE fluorescent probe for the detection and imaging of hydrogen peroxide in living tumor cells and in vivo DOI
Zihao Peng, Mengyuan Cui,

Junling Chu

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 150, P. 107592 - 107592

Published: June 24, 2024

Language: Английский

Citations

2
Aggregation-Induced Emission: Application in Diagnosis and Therapy of Hepatocellular Carcinoma DOI

Wenjing Xu,

Danfeng Jian,

Yang Huang

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 266, P. 116722 - 116722

Published: Aug. 29, 2024

Language: Английский

Citations

1