A Novel Delivery System for the Combined Use of Natural Ingredients: The Preparation of Berberine Hydrochloride–Matrine Liposomes and Preliminary Exploration of Their Anti-Tumor Activity DOI Creative Commons
Min Xu,

Zhangkai Ye,

Junjing Liu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5210 - 5210

Published: Nov. 4, 2024

Berberine hydrochloride (BH) extracted from Coptis chinensis (CC) and Matrine (MT) separated Sophora flavescens (SF) are alkaloids with potent anti-bacterial, anti-inflammatory, anti-tumor effects. Motivated by the clinical practice of using CC SF together, we aimed to demonstrate that synergistic application natural compounds BH MT could enhance therapeutic effects minimize side Two types liposomes, liposomes containing only (BH-LP) both (BH-MT-LP), were successfully prepared via reverse evaporation method. The liposome preparation process was optimized single-factor screening Box–Behnken experimental design results showed had particle sizes in range 222.7 235.4 nm, polydispersity indicated 11.8% 23.3%, zeta potentials −35.9 −31.1 mv. BH-MT-LP superior activity against MDA-MB-231, HepG-2, HGC-27 cells vitro. incorporation effectively promoted effect BH, while controlled release further enhanced efficacy BH. Furthermore, based on flow cytometry results, speculated might promote apoptosis blocking G1 phase inducing cell death. In conclusion, provides evidence for combined use as a stable, safe, practical drug delivery system treatment potential cancers. Meanwhile, successful also new approach traditional Chinese medicine ingredients.

Language: Английский

NIR‐II AIE Liposomes for Boosting Type‐I Photodynamic and Mild‐Temperature Photothermal Therapy in Breast Cancer Treatment DOI Open Access
Shijie Zhen, Zhe Xu,

Meng Suo

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Phototheranositcs has recently aroused extreme attention due to its exceptional advantages. However, the poor photothernostic efficiency, limited penetration depth, strong oxygen‐dependence, and inevitable damage normal tissue of conventional materials severely hindered their total theranostic efficacy. Herein, a series near‐infrared second (NIR‐II) photosensitizers (PSs) featuring aggregation‐induced emission (AIE), NIR‐II fluorescence imaging (FLI), type I photodynamic therapy (PDT) mild‐temperature photothermal (PTT) are constructed through dual‐strategy methods combining donor group engineering fluorination engineering. Profiting from sufficient molecular rotors high electronegativity fluorine, developed 2‐(2‐((5‐(4‐((4‐(diphenylamino)phenyl)(phenyl)amino)phenyl)thiophen‐2‐yl)methylene)‐5,6‐difluoro‐3‐oxo‐2,3‐dihydro‐1H‐inden‐1‐ylidene)malononitrile (BTS‐2F) 2‐(2‐((5‐(4‐(bis(4‐(diphenylamino)phenyl)amino)phenyl)thiophen‐2‐yl)methylene)‐5,6‐difluoro‐3‐oxo‐2,3‐dihydro‐1H‐inden‐1‐ylidene)malononitrile (TTS‐2F) endowed with AIE property, radical reactive oxygen species (ROS) generation ability conversion. Through thin film hydration method, prepared BTS‐2F TTS‐2F loaded liposomes exhibit significant FLI improved type‐I PDT/mild‐temperature PTT under laser irradiation both in vitro orthotopic 4T1 mice models.

Language: Английский

Citations

4
Endogenous Near‐Infrared Chemiluminescence: Imaging‐Guided Non‐Invasive Thrombolysis and Anti‐Inflammation Based on a Heteronuclear Transition Metal Complex DOI Creative Commons
Ziwei Wang, Bo Zhu, Wei Nie

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Conventional therapy to treat thrombi (blood clots) has significant limitations: i) inflammation; ii) bleeding side effects; iii) re-embolisation, and iv) in situ that are not visible. Here it is reported Cu2Ir nanoparticles (NPs) with a Cu-coordinated tetraphenylporphyrin (TPP) core cyclometalated Ir(C^N)2(N^N) substituents integrate long-lived near-infrared (NIR) chemiluminescence (CL) imaging, photothermal (PTT) photodynamic (PDT) for thrombolysis, antioxidant anti-inflammatory properties. Based on density functional theory calculations the chemiluminescent reaction site between TPP peroxynitrite (ONOO-) confirmed first time. The presence of transition metal significantly improves properties TPP. Upon specific activation by ONOO-, NPs exhibited more than 30-fold NIR CL intensity NPs, luminescence lasted 60 min allowing precise long-lasting dynamic tracking thrombi. achieved non-invasive safe thrombolytic triggered irradiation at signaling site. 72.3% blood reperfusion obtained nearly complete restoration flow, re-embolism prevented mouse carotid artery model. Furthermore, scavenged excess reactive oxygen/nitrogen species (RONS) reduced inflammatory factors. hold promise as single-molecule strategy diagnosing treating diseases associated thrombosis.

Language: Английский

Citations

0
Polypeptide nanoparticles obstruct glucose supply for NIR-II fluorescence-guided tumor starvation and enhanced mild photothermal therapy DOI
Yating Wang, Yixuan Xu,

Dejia Chen

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Glucose oxidase-embedded mesoporous polydopamine nanoparticles produce CO for synergistic tumor starvation, chemodynamic, and photothermal therapy DOI
Lingli Guo,

Nan Wang,

Yuqin Zhang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114729 - 114729

Published: April 1, 2025

Language: Английский

Citations

0
Engineering a Near-Infrared Spiro-Based Aggregation-Induced Emission Luminogen for DNAzyme-Sensitized Photothermal Therapy with High Efficiency and Accuracy DOI
Yingying Chen, Shengyi Yang, Xinwen Ou

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(51), P. 35462 - 35477

Published: Dec. 12, 2024

Aggregation-induced emission luminogen (AIEgens)-based photothermal therapy (PTT) has grown into a sparkling frontier for tumor ablation. However, challenges remain due to the uncoordinated photoluminescence (PL) and properties of classical AIEgens, along with hyperthermia-induced antiapoptotic responses in cells, hindering satisfactory therapeutic outcomes. Herein, near-infrared (NIR) spiro-AIEgen TTQ-SA was designed boosted PTT by auxiliary DNAzyme-regulated cell sensitization. unique molecular structure packing mode initially fabricated, endowing it strong AIE effect, favorable PL quantum yield, good performance. DNAzyme, as gene silencing tool, could alleviate antiapoptosis response during PTT. By integrating DNAzyme folate-modified poly(lactic-co-glycolic acid) (PLGA) polymer, as-fabricated nanosystem promote apoptosis sensitize cells PTT, thereby maximizing With combination spiro-AIEgen-based DNAzyme-based silencing, as-designed showed promising NIR imaging abilities targeting demonstrated significant apoptotic, antitumor, antimetastasis effects against orthotopic breast cancer. Furthermore, synergistic antitumor effect realized spontaneous MMTV-PyMT transgenic mice. These findings offer new insights AIEgen-based theranostics sensitization, paving way silencing-PTT nanoplatforms clinical research.

Language: Английский

Citations

3
A Novel Delivery System for the Combined Use of Natural Ingredients: The Preparation of Berberine Hydrochloride–Matrine Liposomes and Preliminary Exploration of Their Anti-Tumor Activity DOI Creative Commons
Min Xu,

Zhangkai Ye,

Junjing Liu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5210 - 5210

Published: Nov. 4, 2024

Berberine hydrochloride (BH) extracted from Coptis chinensis (CC) and Matrine (MT) separated Sophora flavescens (SF) are alkaloids with potent anti-bacterial, anti-inflammatory, anti-tumor effects. Motivated by the clinical practice of using CC SF together, we aimed to demonstrate that synergistic application natural compounds BH MT could enhance therapeutic effects minimize side Two types liposomes, liposomes containing only (BH-LP) both (BH-MT-LP), were successfully prepared via reverse evaporation method. The liposome preparation process was optimized single-factor screening Box–Behnken experimental design results showed had particle sizes in range 222.7 235.4 nm, polydispersity indicated 11.8% 23.3%, zeta potentials −35.9 −31.1 mv. BH-MT-LP superior activity against MDA-MB-231, HepG-2, HGC-27 cells vitro. incorporation effectively promoted effect BH, while controlled release further enhanced efficacy BH. Furthermore, based on flow cytometry results, speculated might promote apoptosis blocking G1 phase inducing cell death. In conclusion, provides evidence for combined use as a stable, safe, practical drug delivery system treatment potential cancers. Meanwhile, successful also new approach traditional Chinese medicine ingredients.

Language: Английский

Citations

1