Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

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Realizing Record‐High Electroluminescence Efficiency of 31.5 % for Red Thermally Activated Delayed Fluorescence Molecules

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(44), P. 23635 - 23640

Published: Aug. 30, 2021

Tailor-made red thermally activated delayed fluorescence (TADF) molecules comprised of an electron-withdrawing pyrazino[2,3-f][1,10]phenanthroline-2,3-dicarbonitrile core and various electron-donating triarylamines are developed. They can form intramolecular hydrogen-bonding, which is conducive to improving emission efficiency promoting horizontal orientation show near infrared (NIR) emissions (692-710 nm) in neat films (606-630 with high photoluminescence quantum yields (73-90%) doped films. prefer large dipole ratios films, rendering optical out-coupling factors (0.39-0.41). Their non-doped OLEDs exhibit NIR lights (716-748 maximum external efficiencies (ηext,max ) 1.0-1.9%. And their radiate (606-648 achieve record-beating ηext,max up 31.5%. These new TADF materials should have great potentials display lighting devices.

Language: Английский

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Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(33), P. 15391 - 15402

Published: Aug. 10, 2022

Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) using small-molecule dyes has high potential for clinical use. However, many NIR-II suffer from emission quenching effect and extremely low quantum yields (QYs) practical usage forms. The AIE strategy been successfully utilized to develop with donor–acceptor (D–A) structures acceptable QYs aggregate state, but there is still large room QY improvement. Here, we rationally designed a emissive dye named TPE-BBT its derivative (TPEO-BBT) by changing electron-donating triphenylamine unit tetraphenylethylene (TPE). Their nanoparticles exhibited ultrahigh relative of 31.5% 23.9% water, respectively. By an integrating sphere, absolute was measured be 1.8% water. Its crystals showed 10.4%, which highest value among organic small molecules reported so far. optimized D–A interaction higher rigidity state are believed two key factors QY. Finally, photoluminescence (PL) chemiluminescence (CL) bioimaging through successive CL resonance energy transfer Förster processes. realized excellent PL quality mouse blood vessels local arthrosis inflammation mice signal-to-background ratio 130. Thus, design presented here brings new possibilities development bright technologies.

Language: Английский

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Cationization-Enhanced Type I and Type II ROS Generation for Photodynamic Treatment of Drug-Resistant Bacteria

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 9130 - 9141

Published: May 18, 2022

Photodynamic therapy as an emerging phototheranostic approach holds great potential for antibacterial treatment, but is limited by compromised reactive oxygen species (ROS) generation in aggregate and hypoxic microenvironment. Herein, we report a molecular cationization to boost the ROS, especially type I ROS of aggregation-induced emission (AIE) photosensitizers photodynamic treatment drug-resistant bacteria. Such reinforces electron-accepting ability cationic moiety, promotes intersystem crossing (ISC), increases electron separation transfer processes. The resultant CTBZPyI exhibits largely enhanced with predominant hydroxyl radical over its neutral counterpart aggregate. Moreover, also confers bacterial binding moderate inactivation dark. Further light irradiation leads superb performance, which healing process MRSA-infected wound. strategy expected be general design highly effective infection treatment.

Language: Английский

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Efficient NIR-II Type-I AIE Photosensitizer for Mitochondria-Targeted Photodynamic Therapy through Synergistic Apoptosis–Ferroptosis

ACS Nano, Journal Year: 2023, Volume and Issue: 17(10), P. 9110 - 9125

Published: May 5, 2023

Hypoxia, the hallmark of malignant tumors, has been recognized as a major obstacle for photodynamic therapy (PDT). Precisely targeting cancer cells in intricate biological scenarios by hypoxia-resistant photosensitizer (PS) is cornerstone to conquer inevitable tumor recurrence and metastasis. Herein, we describe an organic NIR-II PS (TPEQM-DMA) possessing potent type-I phototherapeutic efficacy overcome intrinsic pitfalls PDT combating hypoxic tumors. TPEQM-DMA exhibited prominent emission (>1000 nm) with aggregation-induced feature efficiently produced superoxide anion hydroxyl radical aggregate state under white light irradiation exclusively through low-O2-dependent photochemical process. The suitable cationic nature assisted accumulate cancerous mitochondria. Meanwhile, impaired cellular redox homeostasis, led mitochondrial dysfunction, raised level lethal peroxidized lipids, which induced apoptosis ferroptosis. This synergistic cell death modality enabled suppress growth cells, multicellular spheroids, To improve pharmacological properties TPEQM-DMA, nanoparticles were prepared encapsulation polymer. In vivo experiments proved appealing fluorescence imaging-guided effect

Language: Английский

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Boosting external quantum efficiency to 38.6% of sky-blue delayed fluorescence molecules by optimizing horizontal dipole orientation

Science Advances, Journal Year: 2021, Volume and Issue: 7(43)

Published: Oct. 21, 2021

To achieve high electroluminescence efficiency, great efforts are devoted to enhancing photoluminescence quantum yield (ΦPL) and exciton utilization of luminescent molecule, while another important factor, light out-coupling efficiency (ηout), receives less attention in molecule design. Here, we focus on horizontal dipole orientation engineering the increase ηout external (ηext). A series tailor-made molecules consisting an electron-accepting carbonyl core plus double electron-donating groups spiro[acridine-9,9′-fluorene] carbazole derivatives [e.g., 1,3,5-tri(carbazol-9-yl)benzene] developed systematically investigated. These hold distinguished merits strong sky-blue delayed fluorescence with excellent ΦPL values, large ratios, balanced bipolar carrier transport, which furnish record-high ηext values up 26.1 38.6% nondoped doped organic light-emitting diodes (OLEDs), respectively. Moreover, state-of-the-art hybrid white OLED all-fluorescence single-emitting layer also realized, demonstrating potentials industry these molecules.

Language: Английский

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Realizing efficient blue and deep-blue delayed fluorescence materials with record-beating electroluminescence efficiencies of 43.4%

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 10, 2023

As promising luminescent materials for organic light-emitting diodes (OLEDs), thermally activated delayed fluorescence are booming vigorously in recent years, but robust blue ones still remain challenging. Herein, we report three highly efficient and deep-blue comprised of a weak electron acceptor chromeno[3,2-c]carbazol-8(5H)-one with rigid polycyclic structure donor spiro[acridine-9,9'-xanthene]. They hold distinguished merits excellent photoluminescence quantum yields (99%), ultrahigh horizontal transition dipole ratios (93.6%), fast radiative reverse intersystem crossing, which furnish superb electroluminescence Commission Internationale de I'Eclairage coordinates (CIEx,y) (0.14, 0.18) 0.15) record-beating external efficiencies (ηexts) 43.4% 41.3%, respectively. Their efficiency roll-offs successfully reduced by suppressing triplet-triplet singlet-singlet annihilations. Moreover, high-performance green hyperfluorescence OLEDs achieved utilizing these as sensitizers multi-resonance dopants, providing state-of-the-art ηexts 32.5% (CIEx,y = 0.14, 0.10) 37.6% 0.32, 0.64), respectively, well greatly advanced operational lifetimes. These splendid results can surely inspire the development devices.

Language: Английский

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Fibrous Aerogels with Tunable Superwettability for High-Performance Solar-Driven Interfacial Evaporation

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 10, 2023

Abstract Solar-driven interfacial evaporation is an emerging technology for water desalination. Generally, double-layered structure with separate surface wettability properties usually employed evaporator construction. However, creating materials tunable a great challenge because the of existing monotonous. Herein, we report vinyltrimethoxysilane as single molecular unit to hybrid bacterial cellulose (BC) fibrous network, which can be built into robust aerogel entirely distinct through controlling assembly pathways. Siloxane groups or carbon atoms are exposed on BC nanofibers, resulting in either superhydrophilic superhydrophobic aerogels. With this special property, component-modified aerogels could integrated Under 1 sun, our achieves high rates 1.91 and 4.20 kg m −2 h −1 under laboratory outdoor solar conditions, respectively. Moreover, shows unprecedented lightweight, structural robustness, long-term stability extreme excellent salt-resistance, highlighting advantages synthesis from unit."Image missing"

Language: Английский

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Mesityl‐Functionalized Multi‐Resonance Organoboron Delayed Fluorescent Frameworks with Wide‐Range Color Tunability for Narrowband OLEDs

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(38)

Published: June 27, 2022

Polycyclo-heteraborin multi-resonance (MR) emitters are promising for high color-purity organic light-emitting diodes (OLEDs). Here, unlike the most common heteroatom ternary-doped (X/B/N) frameworks, a binary-doped (B/N) skeleton is reported with large energy band wide-range color tunability. Based on this parent-segment, "one-pot" catalyst-free borylation method developed which generates deep blue to pure green MR from readily available starting materials, peaks at 426-532 nm and full-width-at-half-maxima of 27-38 nm. Impressively, maximum external quantum efficiency nearly 40 % recorded corresponding device Commission Internationale de l'Eclairage coordinates (0.14, 0.16), representing state-of-the-art performances. This work presents new paradigm synthesis B/N-doped will motivate study other novel frameworks.

Language: Английский

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Pyrene-Based AIE Active Materials for Bioimaging and Theranostics Applications

Biosensors, Journal Year: 2022, Volume and Issue: 12(7), P. 550 - 550

Published: July 21, 2022

Aggregation-induced emission (AIE) is a unique research topic and property that can lead to wide range of applications, including cellular imaging, theranostics, analyte quantitation the specific detection biologically important species. Towards development AIE-active materials, many aromatic moieties composed tetraphenylethylene, anthracene, pyrene, etc., have been developed. Among these moieties, pyrene an hydrocarbon with polycyclic flat structure containing four fused benzene rings provide unusual electron delocalization feature in AIE property. Numerous pyrene-based materials reported towards sensing, imaging theranostics applications. Most importantly, exist as small molecules, Schiff bases, polymers, supramolecules, metal-organic frameworks, etc. This comprehensive review outlines utilizations on studies. Moreover, design synthesis molecules are delivered discussions their future scopes.

Language: Английский

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