Age at Menarche and Its Potential Role in Early Detection of Hyperandrogenic Polycystic Ovary Syndrome
American Journal of Physical Anthropology,
Journal Year:
2025,
Volume and Issue:
186(4)
Published: April 1, 2025
ABSTRACT
Objectives
Polycystic
ovary
syndrome
(PCOS)
is
a
multifaceted
heritable
endocrine
disorder
that
affects
4%–20%
of
females
worldwide.
Characterized
by
symptoms
such
as
polycystic
ovaries,
anovulation,
and
hyperandrogenism,
PCOS
remains
challenging
to
diagnose,
particularly
in
its
early
stages.
Research
suggests
women
with
may
experience
earlier
onset
menarche,
but
the
mechanisms
behind
this
association
are
not
well
understood.
This
study
explores
whether
menarche
could
serve
an
effective
diagnostic
marker
for
PCOS.
Materials
Methods
A
survey
was
conducted
95
adult
(ages
19–62),
divided
into
two
groups:
diagnosed
(49%,
n
=
47)
without
(51%,
48).
Participants
self‐identified
were
required
meet
Rotterdam
Criteria
diagnosis.
Notably,
all
participants
exhibited
hyperandrogenic
phenotype.
Independent
samples
t
‐tests
linear
regression
used
data
analysis.
Results
Women
reached
average
1.8
years
than
those
condition
(mean
age
11.4
±
1.6
vs.
13.2
1.2
years).
Discussion
These
findings
suggest
be
promising,
underexplored
indicator
PCOS,
offering
potential
new
avenue
diagnosis
condition.
valuable,
often
until
more
classic
symptoms,
anovulation
or
hirsutism,
emerge.
Further
research
needed
confirm
these
results
investigate
underlying
mechanisms.
Language: Английский
Longitudinal analysis of cortisol changes during pubertal development in indigenous Qom girls
American Journal of Human Biology,
Journal Year:
2024,
Volume and Issue:
36(10)
Published: July 21, 2024
Abstract
Pubertal
research
has
primarily
focused
on
hypothalamic–pituitary–gonadal
axis
(HPG)
regulation
of
puberty,
though
the
hypothalamic–pituitary–adrenal
(HPA)
is
increasingly
considered
critical.
Heightened
HPA
function
proxied
by
increasing
cortisol
levels
may
play
a
role
in
accelerated
pubertal
timing.
However,
extent
to
which
varies
across
ages
and
its
relation
changes
linear
growth
are
less
well
substantiated.
We
explored
relationships
between
age,
growth,
adiposity,
C‐peptide
(proxy
for
insulin),
we
tested
whether
higher
associated
with
earlier
at
menarche
peak
height
velocity.
utilize
longitudinal
data
(
n
=
777
urine
samples)
from
Qom
females
7–14
46)
test
our
pre‐registered
analysis
using
Bayesian
mixed
effects
models
joint
modeling
techniques.
find
limited
evidence
supporting
overarching
hypothesis
that
upregulation
maturation
or
some
upregulation,
as
cortisol,
be
more
clearly
related
differences
relative
early‐mid
measured
height‐for‐age
z
‐scores.
Transdisciplinary
perspectives
including
assumption
stressors
acting
via
accelerate
development,
discussed.
Language: Английский