Can epigenetics shine a light on the biological pathways underlying major mental disorders?

Psychological Medicine, Journal Year: 2022, Volume and Issue: 52(9), P. 1645 - 1665

Published: Feb. 23, 2022

Abstract A significant proportion of the global burden disease can be attributed to mental illness. Despite important advances in identifying risk factors for health conditions, biological processing underlying causal pathways onset remain poorly understood. This represents a limitation implement effective prevention and development novel pharmacological treatments. Epigenetic mechanisms have emerged as mediators environmental genetic which might play role onset, including childhood adversity (CA) cannabis use (CU). Particularly, human research exploring DNA methylation has provided new promising insights into implicated aetio-pathogenesis psychiatric including: monoaminergic (Serotonin Dopamine), GABAergic, glutamatergic, neurogenesis, inflammatory immune response oxidative stress. While these epigenetic changes been often studied disease-specific, similarly investigation factors, they are transdiagnostic. Therefore, we aim review existing literature on from studies diseases (i) identify modifications mapping onto either transdiagnostically or specifically related such Eating Disorders, Post-traumatic Stress Disorder, Bipolar Psychotic Depression, Autism Spectrum Disorder Anxiety (ii) investigate convergence between some exposure known disorders CA CU, well other confounders psychiatry research.

Language: Английский

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Lifetime marijuana use and epigenetic age acceleration: A 17-year prospective examination

Drug and Alcohol Dependence, Journal Year: 2022, Volume and Issue: 233, P. 109363 - 109363

Published: Feb. 17, 2022

Language: Английский

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Genome-wide DNA methylation association study of recent and cumulative marijuana use in middle aged adults

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(6), P. 2572 - 2582

Published: May 31, 2023

Marijuana is a widely used psychoactive substance in the US and medical recreational legalization has risen over past decade. Despite growing number of individuals using marijuana, studies investigating association between epigenetic factors recent cumulative marijuana use remain limited. We therefore investigated DNA methylation levels. Participants from Coronary Artery Risk Development Young Adults Study with whole blood collected at examination years (Y) 15 Y20 were randomly selected to undergo profiling both timepoints Illumina MethylationEPIC BeadChip. Recent was queried each estimate Y0 Y15 Y20. At (n = 1023), we observed 22 31 markers associated (FDR P ≤ 0.05) 132 16 883), respectively. replicated 8 previously reported use. further identified 640 cis-meQTLs 198 DMRs Differentially methylated genes statistically overrepresented pathways relating cellular proliferation, hormone signaling, infections as well schizophrenia, bipolar disorder, substance-related disorders. numerous markers, pathways, diseases middle-aged adults, providing additional insight into epigenome. These results provide novel insights role on epigenome related health conditions.

Language: Английский

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Epigenetic effects of cannabis: A systematic scoping review of behavioral and emotional symptoms associated with cannabis use and exocannabinoid exposure

Drug and Alcohol Dependence, Journal Year: 2024, Volume and Issue: 263, P. 111401 - 111401

Published: July 27, 2024

Recent research suggests that epigenetic modifications may mediate the behavioral effects of cannabis, influencing exocannabinnoids' long term in cognitive function and its role emergence psychotic symptoms. In this systematic scoping review, we assessed current evidence associated with use cannabis or exocannabinoid administration their relationship emotional We searched PubMed, Cochrane CENTRAL, Web Science, up to January 2022, using terms "cannabis" "epigenetics." The search yielded 178 articles, which 43 underwent full article revision; 37 articles were included review. gathered observational cross-sectional studies conducted on human subjects experimental designs animal models conveyed disparity dosage, methods assessment targeted mechanisms. Nine performed epigenome-wide analysis identification differentially methylated sites; most these found a global hypomethylation, enrichment genes related cellular survival neurodevelopment. Other methylation at specific exposure was reduced Cg05575921, DNMT1, DRD2, COMT, DLGAP2, Arg1, STAT3, MGMT, PENK, while hypermethylation DNMT3a/b, NCAM1, AKT1. review an exocannabinoid-induced changes modulate depressive-anxious, psychotic, addictive behavioural phenotypes. Further will require dosage exposure/administration uniformization customized pool assess suitability as biomarkers for psychiatric diseases.

Language: Английский

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Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 9, 2025

Language: Английский

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Cannabis Use, Pulmonary Function, and Lung Cancer Susceptibility: A Mendelian Randomization Study

Journal of Thoracic Oncology, Journal Year: 2021, Volume and Issue: 16(7), P. 1127 - 1135

Published: April 21, 2021

Language: Английский

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Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension

Epigenetics, Journal Year: 2023, Volume and Issue: 18(1)

Published: May 22, 2023

Tobacco, alcohol, and marijuana consumption is an important public health problem because of their high use worldwide association with the risk mortality many conditions, such as hypertension, which commonest factor for death throughout world. A likely pathway action substance leading to persistent hypertension DNA methylation. Here, we evaluated effects tobacco, on methylation in same cohort (N = 3,424). Three epigenome-wide studies (EWAS) were assessed whole blood using InfiniumHumanMethylationEPIC BeadChip. We also mediation top CpG sites between hypertension. Our analyses showed 2,569 differentially methylated by alcohol drinking 528 tobacco smoking. did not find significant associations after correcting multiple comparisons. found 61 genes overlapping that enriched biological processes involved nervous cardiovascular systems. In analysis, 66 significantly mediated effect The alcohol-related site (cg06690548, P-value 5.9·10−83) mapped SLC7A11 strongly 70.5% (P-value 0.006). findings suggest should be considered new targets prevention management, particularly concerning consumption. data encourage further research into study neurological

Language: Английский

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Prenatal cannabis exposure is associated with alterations in offspring DNA methylation at genes involved in neurodevelopment, across the life course

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 14, 2024

Language: Английский

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DNA methylation and the opposing NMDAR dysfunction in schizophrenia and major depression disorders: a converging model for the therapeutic effects of psychedelic compounds in the treatment of psychiatric illness

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(11), P. 4553 - 4567

Published: Sept. 7, 2023

Language: Английский

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Methylomic Investigation of Problematic Adolescent Cannabis Use and Its Negative Mental Health Consequences

Journal of the American Academy of Child & Adolescent Psychiatry, Journal Year: 2021, Volume and Issue: 60(12), P. 1524 - 1532

Published: Feb. 23, 2021

Language: Английский

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