3-Methyl-1-phenyl-4-thioacetylpyrazol-5-one DOI Creative Commons
Zhanina Petkova, Rusi Rusew, Boris Shivachev

et al.

Molbank, Journal Year: 2023, Volume and Issue: 2023(1), P. M1588 - M1588

Published: Feb. 15, 2023

The novel compound 3-methyl-1-phenyl-4-thioacetylpyrazol-5-one is obtained in excellent yield via a thionation of the corresponding oxygen analogue. product isolated pure form using column chromatography and characterised 1D 2D NMR experiments, ATR IR HRMS spectra, single-crystal XRD.

Language: Английский

A Focused Review of Synthetic Applications of Lawesson’s Reagent in Organic Synthesis DOI Creative Commons
Hena Khatoon, Emilia Abdulmalek

Molecules, Journal Year: 2021, Volume and Issue: 26(22), P. 6937 - 6937

Published: Nov. 17, 2021

Lawesson’s reagent (LR) is a well-known classic example of compound with unique construction and unusual chemical behavior, wide range applications in synthetic organic chemistry. Its main functions were rounded for the thionation various carbonyl groups early days, exemplary results. However, role synthesis has changed drastically, now its use can help chemistry community to understand innovative ideas. These include constructing biologically valuable heterocycles, coupling reactions, natural compounds. The ease availability convenient usage LR as thionating agent made us compile review on new diverse some common functional groups, such ketones, esters, amides, alcohols, carboxylic acids, biological applications. Since are diverse, we have also included classes heterocycles thiazepines, phosphine sulfides, thiophenes, organothiophosphorus Thionation essential steroids terpenoids been compiled. This discusses recent insights into this famous from 2009 January 2021.

Language: Английский

Citations

24
A Recent Progress for the Synthesis of Thiocarboxylates DOI
Xi Wang, Zhi‐Bing Dong

European Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 2022(25)

Published: May 31, 2022

Abstract As a common and integral feature of many natural products, thiocarboxylates play an important role in biologically or pharmaceutically active compounds. Thiocarboxylates often show unique physiological activities biology drugs, which inspires new therapeutic drugs. The related research developments thioester‐based medicinal chemistry have been rapidly developing increasingly topic the last two decades. In this review, we will summarize main methods for synthesis thiocarboxylates, might provide general ideas to access more effective

Language: Английский

Citations

18
A ternary composite nanofibrous photocatalyst: FcLR-gC3N4/polyisothianaphthene/polyacrylonitrile for degradation of organic dyes DOI
Shadi Asgari, Ghodsi Mohammadi Ziarani,

Alireza Badiei

et al.

Journal of the Taiwan Institute of Chemical Engineers, Journal Year: 2024, Volume and Issue: 163, P. 105672 - 105672

Published: July 23, 2024

Language: Английский

Citations

3
Base‐promoted Oxidative Sulfuration/Cyclization to Construct Naphtho[2,3‐d]thiazole through Three‐component Reaction Using S8 as the Sulfur Source DOI

Zihua Yu,

Junyi Su,

Chenxi Huang

et al.

Asian Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 11(11)

Published: Aug. 8, 2022

Abstract A base‐promoted three‐component oxidative sulfuration/cyclization reaction of 2‐amino‐1,4‐naphthoquinone, aldehyde and elemental sulfur was developed. The naphtho[2,3‐d]thiazole ring determined by forming two C−S bonds one C=N bond, which demonstrates the advantages cheap raw materials, no transition metal, economic efficiency. substrate scope broad with aromatic aliphatic aldehydes. mechanistic study might promote design for a reaction.

Language: Английский

Citations

8
Lawesson’s Reagent: Providing a New Approach to the Forgotten 6-Thioverdazyl Radical DOI

Margot Duggin,

Wesley J. Olivier, Allan J. Canty

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(13), P. 9405 - 9419

Published: June 12, 2024

A new method for the preparation of underrepresented 1,5-dimethyl-6-thioverdazyl radicals has been developed employing Lawesson's reagent (LR). The synthetic route involves direct thionation carbonyl group corresponding dialkylbishydrazone followed by cyclization to give tetrazinanthione verdazyl precursor on a gram scale. Subsequent oxidation yields 6-thioverdazyl radical. It was determined that substrates containing electron-withdrawing groups in

Language: Английский

Citations

1
Lawesson's reagent promoted deoxygenation of azlactones for the syntheses of 2,4-disubstituted thiazoles DOI

Gaofeng Yin,

Xiaodong Wang, Yuqing Wang

et al.

Organic & Biomolecular Chemistry, Journal Year: 2022, Volume and Issue: 20(48), P. 9589 - 9592

Published: Jan. 1, 2022

A new method for the straightforward syntheses of 2,4-disubstituted thiazoles from azlactones via deoxygenation with Lawesson's reagent has been developed.

Language: Английский

Citations

5
Synthesis and Chiral Separation of Some 4-thioflavones DOI
Mohammed El Amin Zaid, Nasser Belboukhari, Khaled Sekkoum

et al.

Journal of Chromatographic Science, Journal Year: 2021, Volume and Issue: 59(9), P. 856 - 862

Published: Feb. 8, 2021

Abstract A thionation reaction was performed on some chiral flavanones using Lawesson’s reagent (LR) and leads to the formation of new thiocarbonyl flavanes. LR in this with Hesperetin Naringenin gives flavan-4-thiones yields ranged between 41 52%. Based Wittig principle, is currently most widely used for type reaction. Enantiomeric separation by high-performance liquid chromatography methods then set-up three different polysaccharide-based stationary phases (CSPs). Chiral separations were successfully accomplished high resolution (1.22 ≤ Rs 5.23). The discrimination mechanism(s) analytes under study, mobile phase, CSPs discussed.

Language: Английский

Citations

6
A chromatography-free and aqueous waste-free process for thioamide preparation with Lawesson’s reagent DOI Creative Commons
Wu Ke,

Yichen Ling,

Anwei Ding

et al.

Beilstein Journal of Organic Chemistry, Journal Year: 2021, Volume and Issue: 17, P. 805 - 812

Published: April 9, 2021

After completing the thio-substitution with Lawesson’s reagent, ethanol was found to be effective in decomposition of inherent stoichiometric six-membered-ring byproduct from reagent a highly polarized diethyl thiophosphonate. The treatment significantly simplified following chromatography purification desired thioamide small scale preparation. As scaling up preparation two pincer-type thioamides, we have successfully developed convenient process ethylene glycol replace during workup, including traditional phase separation, extraction, and recrystallization. newly chromatography-free procedure did not generate P-containing aqueous waste, only organic effluents were discharged. It is believed that optimized offers great opportunity applying for various reactions on large scale.

Language: Английский

Citations

5
Ferrocene decorated homoleptic silver(I) clusters: Synthesis, structure, and their electrochemical behaviour DOI

Samreet Khirid,

Dilip Kumar Jangid,

Rathindranath Biswas

et al.

Journal of Organometallic Chemistry, Journal Year: 2021, Volume and Issue: 948, P. 121923 - 121923

Published: June 7, 2021

Language: Английский

Citations

5
Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates DOI

Naglaa F. El- Sayed,

Marwa El‐Hussieny, Shaimaa T. Mansour

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 276, P. 116679 - 116679

Published: July 14, 2024

Language: Английский

Citations

0