The Chemical Record,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 5, 2024
Abstract
31
P
NMR
spectroscopy
is
a
consolidated
tool
for
the
characterization
of
organophosphorus
compounds
and,
more
recently,
reaction
monitoring.
The
evolution
organic
synthesis,
mainly
due
to
combination
elaborated
building
blocks
with
enabling
technologies,
generated
great
challenges
understand
and
optimize
synthetic
methodologies.
In
this
sense,
experiments
also
became
routine
technique
monitoring,
accessing
products
side
yields,
chiral
recognition,
kinetic
data,
intermediates,
as
well
basic
parameters,
such
acid‐base
hydrogen‐bonding.
This
review
deals
these
aspects
demonstrating
essential
role
spectroscopy.
recent
publications
(the
last
ten
years)
will
be
explored,
discussing
strategies
accomplished
detect
and/or
quantify
distinct
molecules,
approaching
mechanism,
stability,
stereochemistry,
utility
probe.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 28, 2024
Abstract
Although
global
vaccination
campaigns
relieved
the
SARS-CoV-2
pandemic
in
terms
of
morbidity
and
mortality,
capability
virus
to
originate
mutants
may
reduce
vaccines
efficiency,
posing
a
serious
risk
fall
into
again.
As
result,
there
is
need
develop
small
molecules
able
tackle
conserved
viral
targets,
such
as
main
protease
(M
pro
).
Here
series
benzisoselenazolones
diselenides
were
tested
for
their
ability
inhibit
M
,
then,
most
potent
compounds,
antiviral
activity
was
measured
vitro,
mechanism
action
investigated.
Density
functional
theory
molecular
docking
procedures
also
implemented
shed
light
protein/compound
interaction.
Finally,
bioorganic
model
set
up
investigate
reaction
between
selenorganic
compounds
biologically
relevant
thiols,
unravel
possible
metabolic
pathways
compounds.
The
overall
results
contribute
identify
novel
Se-containing
active
against
SARS-CoV-2,
clarify
some
important
aspects
mechanisms
inhibitors
targeting
.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(62)
Published: Aug. 19, 2024
Abstract
Herein,
we
report
the
synthesis
of
seleno‐substituted
chromenes
from
selenoalkynes
and
phenols.
In
this
cascade
reaction,
applied
gold
catalyst
not
only
functions
as
a
π‐acid,
but
also
Lewis
acid,
enabling
propargylic
substitution
in
first
step
to
connect
oxygen
carbon
bond.
Under
optimal
reaction
condition
total
26
were
accessible
by
modular
access.
During
scale
up
experiments,
hydrolysis
vinylselenium
substructure
corresponding
chromenones
was
observed.
By
revisiting
electron‐rich
starting
materials,
four
produced
following
one‐pot
using
single
catalyst.
To
better
understand
interaction
selenium,
series
nuclear
magnetic
resonance
studies
high‐resolution
mass
spectrometry
performed,
which
led
proposal
mechanism
for
transformation.
Inorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
63(35), P. 16186 - 16193
Published: Aug. 20, 2024
Calculated
and
measured
77Se
nuclear
magnetic
resonance
(NMR)
chemical
shift
data
on
a
diverse
collection
of
13
selenaborane
cluster
compounds,
containing
total
19
selenium
centers,
reveals
correlation
between
shifts
the
intracluster
coordination
atoms
within
their
borane
frameworks.
A
plot
against
calculated
NMR
shows
an
approximately
linear
relationship
that
can
serve
as
predictive
tool
in
assessing
range
which
vertex
from
particular
compound
might
be
expected
to
found,
thereby
reducing
expensive
experimental
time.
Furthermore,
relative
vertices
clusters
more
than
one
atom
are
consistent
across
range,
thus
allowing
assignment
resonances
with
high
degree
confidence
even
relatively
low-level
density
functional
theory
calculations.
new
macropolyhedral
20-vertex
Se2B18H20
(A)
is
also
reported.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 2, 2024
Abstract
The
efficient
construction
of
chalcogen‐atom‐based
chiral
compounds
remains
a
challenge,
despite
the
importance
organoselenium
and
organosulfur
in
life
materials
science.
Chalcogen
atoms
can
form
net
attractive
interactions
called
chalcogen
bonds,
but
it
is
an
undeveloped
tool
to
assist
asymmetric
catalysis.
Herein,
we
report
enantioselective
insertion
platform
install
stereogenic
center
bearing
selenyl
thiocyano
functional
groups.
Our
method
operates
by
synergistic
catalysis
guanidine
achiral
dirhodium
complex
three‐component
or
four‐component
reaction,
through
Se−S
bond
into
carbene
species,
competing
successfully
with
spontaneous
racemic
process
showing
high
regioselectivity.
As
elucidated
spectroscopic
experiments
computational
studies,
unique
mechanism
involving
as
well
hydrogen
bonding
was
established
account
for
enantiocontrol.
stereoselectivity
holds
broad
array
selenylthiocyanatopropanoates,
which
showed
excellent
anti‐inflammatory
toward
IL‐1β
low
cytotoxicity.
The Chemical Record,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 5, 2024
Abstract
31
P
NMR
spectroscopy
is
a
consolidated
tool
for
the
characterization
of
organophosphorus
compounds
and,
more
recently,
reaction
monitoring.
The
evolution
organic
synthesis,
mainly
due
to
combination
elaborated
building
blocks
with
enabling
technologies,
generated
great
challenges
understand
and
optimize
synthetic
methodologies.
In
this
sense,
experiments
also
became
routine
technique
monitoring,
accessing
products
side
yields,
chiral
recognition,
kinetic
data,
intermediates,
as
well
basic
parameters,
such
acid‐base
hydrogen‐bonding.
This
review
deals
these
aspects
demonstrating
essential
role
spectroscopy.
recent
publications
(the
last
ten
years)
will
be
explored,
discussing
strategies
accomplished
detect
and/or
quantify
distinct
molecules,
approaching
mechanism,
stability,
stereochemistry,
utility
probe.
