Pseudo‐Multicomponent Reactions of Lawsone: Synthetic Strategies of Bis‐Lawsone

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 1, 2025

Abstract 1,4‐Naphthoquinones (1,4‐NQs) are an important class of molecules with diverse pharmaceutical applications. Lawsone, a naturally occurring molecule range bioactivities, falls in the 1,4‐NQs. It possesses 1,3‐dicarbonyl functionality, which has been utilized synthesis bis‐lawsones reaction aldehydes. In this review we have discussed notable developments bis‐lawsone from 2009 to 2023. Also, highlights limitations and future perspectives area.

Language: Английский

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Recent advances in the transition-metal-free synthesis of quinoxalines

RSC Advances, Journal Year: 2021, Volume and Issue: 11(59), P. 37325 - 37353

Published: Jan. 1, 2021

Recent advances in the synthesis of quinoxalines under transition metal free conditions are summarized this review article.

Language: Английский

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Sonochemistry in an organocatalytic domino reaction: an expedient multicomponent access to structurally functionalized dihydropyrano[3,2-b]pyrans, spiro-pyrano[3,2-b]pyrans, and spiro-indenoquinoxaline-pyranopyrans under ambient conditions

RSC Advances, Journal Year: 2022, Volume and Issue: 12(20), P. 12843 - 12857

Published: Jan. 1, 2022

A highly convenient and sustainable one-pot approach for the diversely-oriented synthesis of a variety medicinally privileged amino-substituted 4,8-dihydropyrano[3,2-

Language: Английский

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Ultrasound-assisted transition-metal-free catalysis: a sustainable route towards the synthesis of bioactive heterocycles

RSC Advances, Journal Year: 2022, Volume and Issue: 12(22), P. 14022 - 14051

Published: Jan. 1, 2022

Heterocycles of synthetic and natural origin are a well-established class compounds representing broad range organic molecules that constitute over 60% drugs agrochemicals in the market or research pipeline. Considering vast abundance these structural motifs, development chemical processes providing easy access to novel complex target by introducing environmentally benign conditions with main focus on improving cost-effectiveness transformation is highly demanding challenging. Accordingly, sonochemistry appears be an excellent alternative feasible energy input has recently received considerable steadily increasing interest synthesis. However, involvement transition-metal-catalyst(s) process often triggers unintended impact greenness sustainability transformation. Consequently, enormous efforts have been devoted developing metal-free routes for assembling various heterocycles medicinal interest, particularly under ultrasound irradiation. The present review article aims demonstrate brief overview current progress accomplished ultrasound-assisted synthesis pharmaceutically relevant diverse using transition-metal-free catalysis.

Language: Английский

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Synthesis and evaluation of the antioxidant activity of new spiro-1,2,4-triazine derivatives applying Ag/Fe3O4/CdO@MWCNT MNCs as efficient organometallic nanocatalysts

Frontiers in Chemistry, Journal Year: 2022, Volume and Issue: 10

Published: Sept. 29, 2022

We applied the Petasites hybridus rhizome water extract as green media so that Ag/Fe 3 O 4 /CdO@ multi-walled carbon nanotubes magnetic nanocomposites (Ag/Fe /CdO@MWCNTs MNCs) could be prepared. also evaluated its activity by using in one-pot multicomponent reaction of acetophenones, diethyl oxalate, ammonium acetate, and activated carbonyl compounds such ninhydrin, isatin acenaphthylene-1,2-dione, malononitrile hydrazoyl chlorides an aqueous medium at room temperature for generation spiro-1,2,4-triazines new derivatives with tremendous output. Moreover, reducing organic pollutants from 4-nitrophenol (4-NP) was carried out generating temperature. The results displayed reduced a short time. synthesized have NH OH functional groups having acidic hydrogen high antioxidant power. Also, exhibited antimicrobial ability. For this purpose, disk diffusion method two kinds bacteria, Gram-positive Gram-negative, were employed analysis. Furthermore, we theory-based quantum chemical methods order to better understand mechanism density. To generate spiro-1,2,4-triazines, process showed many properties reactions time, products good yields, simple extraction catalyst mixture reactions.

Language: Английский

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Recent advances in the synthesis and applications of furocoumarin derivatives

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 34(9), P. 108396 - 108396

Published: March 30, 2023

Language: Английский

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Visible-light-induced organophotocatalytic and singlet oxygen-initiated domino construction of 1,4-dihydropyridines, C-3 functionalized spiro[indoline-3,4′-pyridines] and C-11 functionalized spiro[indeno-[1,2-b]quinoxaline-11,4′-pyridines]

Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(7), P. 1518 - 1530

Published: Jan. 1, 2023

A highly efficient pot, atom, and step economical method for the construction of pharmacologically potent structurally functionalized 1,4-dihydropyridines, quaternary centered C-3 spiro[indoline-3,4'-pyridines], C-11 spiro[indeno[1,2-b]quinoxaline-11,4'-pyridines] via rose bengal photoredox catalysis under blue LED irradiation in an aqueous medium at room temperature has been developed. The products were isolated excellent yields within a short reaction time variety functional groups transition metal- ligand-free energy-efficient conditions green solvent system with high mass efficiency process intensity, which are key advantages current work.

Language: Английский

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Recent advances in the microwave- and ultrasound-assisted green synthesis of coumarin-heterocycles

Arabian Journal of Chemistry, Journal Year: 2021, Volume and Issue: 15(3), P. 103654 - 103654

Published: Dec. 20, 2021

Given the importance of highly reactive nature and attractiveness coumarins as a precursor natural products pharmacological agents, tremendous efforts have been dedicated to their synthesis in last decades. Starting from Knoevenagel, Perkin, Kostanecki-Robinson, Pechmann, Reformansky, Baylis Hillman reactions several new one-pot multicomponent, sequential tandem devised. After emergence non-conventional energy sources like microwaves (MW) ultrasound irradiation, field organic has reached an outstanding level this century terms synthetic efficiency well green chemistry viewpoint. Enlightened by this, great deal attention paid bioactive coumarin-heterocycles employing approach vast array procedures established. Therefore, time investigation is required for biological aspects these hybrid molecules. The present review aims highlight current progress achieved either linked or fused with diverse five- six-membered heterocycles making utilization ultrasound-assisted strategies 2014 date. Besides highlighting development field, we attempted point out drawbacks challenges associated reaction discovery, which would hopefully provide impetus future exploration.

Language: Английский

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Brønsted acid catalyzed mechanochemical domino multicomponent reactions by employing liquid assisted grindstone chemistry

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 25, 2023

Here, we have demonstrated a metal-free energy-efficient mechanochemical approach for expedient access to diverse set of 2-amino-3-cyano-aryl/heteroaryl-4H-chromenes, tetrahydrospiro[chromene-3,4'-indoline], 2,2'-aryl/heteroarylmethylene-bis(3-hydroxy-5,5-dimethylcyclohex-2-enone) as well tetrahydro-1H-xanthen-1-one by employing the reactivity 5,5-dimethylcyclohexane-1,3-dione/cyclohexane-1,3-dione with TsOH⋅H2O Brønsted acid catalyst under water-assisted grinding conditions at ambient temperature. The ability accomplish multiple C-C, C=C, C-O, and C-N bonds from readily available starting materials via domino multicomponent strategy in absence metal-catalyst volatile organic solvents an immediate reduction cost transformation without necessitates complex operational procedures, features significant highlights this approach. excellent yield products, broad functional group tolerances, easy set-up, column-free, scalable synthesis ultralow loading, short reaction time, waste-free, ligand-free, toxic-free, are other notable advantages greenness sustainability protocol were also established demonstrating several green metrics parameters.

Language: Английский

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Exploring the synthetic potential of a g-C₃N₄·SO₃H ionic liquid catalyst for one-pot synthesis of 1,1-dihomoarylmethane scaffoldsviaKnoevenagel–Michael reaction

RSC Advances, Journal Year: 2023, Volume and Issue: 13(19), P. 13337 - 13353

Published: Jan. 1, 2023

A highly promising approach for the synthesis of functionalized 1,1-dihomoarylmethane scaffolds (bis-dimedones, bis-cyclohexanediones, bis-pyrazoles, and bis-coumarins) using g-C3N4·SO3H ionic liquid via Knoevenagel-Michael reaction has been developed synthesized derivatives were well characterized spectral studies. The method involved C-H activated acids with a range aromatic aldehydes, in 2 : 1 ratio catalyzed by catalyst. use as catalyst several benefits, such low cost, easy preparation, high stability. It was from urea powder chloro-sulfonic acid thoroughly FT-IR, XRD, SEM, HRTEM. present work unveils environmentally friendly synthesizing yield, selectivity, efficiency, mild conditions, no need chromatographic separation, short times. adheres to green chemistry principles offers viable alternative previously reported methods.

Language: Английский

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