Angewandte Chemie,
Journal Year:
2022,
Volume and Issue:
134(47)
Published: Sept. 26, 2022
Abstract
A
nickel‐catalyzed
reductive
cross‐electrophile
coupling
between
the
redox‐active
N‐
trifluoroethoxyphthalimide
and
iodoarenes
is
documented.
The
protocol
reproduces
a
formal
arylation
of
trifluoroacetaldehyde
under
mild
conditions
in
high
yields
(up
to
88
%)
with
large
functional
group
tolerance
(30
examples).
combined
computational
experimental
investigation
revealed
pivotal
solvent
assisted
1,2‐Hydrogen
Atom
Transfer
(HAT)
process
generate
nucleophilic
α‐hydroxy‐α‐trifluoromethyl
C‐centered
radical
for
Csp
2
−Csp
3
bond
forming
process.
European Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 13, 2025
N
‐alkoxyphthalimides
represent
a
versatile
class
of
redox‐active
alcohol
derivatives
for
carbon–carbon
bond
formation
following
activation
by
single‐electron
reduction.
Herein,
key
precedents
using
the
new
bonds
under
photochemical
reaction
conditions
are
first
presented.
The
merger
these
and
other
strategies
with
Ni
catalysis
in
various
cross‐electrophile
couplings
aryl
halides
is
then
highlighted.
A
particular
focus
made
on
mechanisms
proposed
Ni‐catalyzed
reductive
cross‐couplings.
Concluding
thoughts
future
design
as
C(sp
3
)O
transition
metal‐catalyzed
cross‐couplings
also
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(14), P. 10004 - 10011
Published: June 27, 2024
-Alkoxyphthalimides,
one
kind
of
phthalimide
derivative,
have
great
importance
in
synthesis,
mainly
used
as
free
radical
precursors.
While
the
unit,
for
a
long
time,
was
treated
part
waste
stream.
Construction
C-N
bonds
has
always
been
hot
spot,
especially
reductive
cross-coupling.
Herein,
nickel-catalyzed
cross-coupling
reaction
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(13), P. 2700 - 2704
Published: Jan. 1, 2023
A
silver-catalyzed
cyclization
of
α-imino-oxy
acids
under
mild
conditions
has
been
described.
This
reaction
offers
facile
access
to
a
diverse
range
fused
tetralone
derivatives
with
exquisite
stereoselectivity
in
moderate
good
yields.
Catalysts,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1502 - 1502
Published: Dec. 8, 2023
The
glycine
motif
is
widely
prevalent
in
bioactive
peptides.
Thus,
the
direct
and
precise
modification
of
derivatives
has
attracted
significant
attention
over
past
few
decades.
Among
various
protocols
for
derivatives,
visible-light-driven
α-C(sp3)–H
bond
functionalization
emerged
as
a
powerful
tool
to
achieve
this
objective,
owing
its
merits
atom
economy,
selectivity,
reaction
simplicity,
sustainability.
This
review
summarizes
recent
advancements
derivatives.
contents
are
organized
based
on
photocatalysts
employed
modes
process.
mechanism,
challenges
encountered,
future
trends
also
discussed,
enabling
readers
understand
current
developmental
status
field.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Comprehensive
Summary
A
visible‐light‐induced
decarboxylative
radical
cascade
cyclization
reaction
between
N
‐(2‐cyanoaryl)‐acrylamides
and
alkyl
‐(acyloxy)phthalimide
(NHPI
esters)
for
the
construction
of
phenanthridine
derivatives
has
been
developed.
This
approach
utilizes
lithium
iodide
(LiI)
triphenylphosphine
(PPh
3
)
as
redox
catalysts
is
produced
through
photoactivation
electron
donor‐acceptor
(EDA)
complex.
series
primary,
secondary,
tertiary
alkyl‐substituted
phenanthridines
are
prepared
in
up
to
82%
yield
without
transition‐metal
catalysts,
chemical
oxidants,
or
metal‐/organic
dye‐based
photocatalysts.
Synlett,
Journal Year:
2023,
Volume and Issue:
35(03), P. 268 - 278
Published: July 18, 2023
Abstract
We
report
herein
recent
advances
made
by
our
group
and
others
in
the
field
of
oxygen-centered
radicals
generated
under
photocatalysis.
Thanks
to
design
new
O-radical
precursors,
these
can
now
be
efficiently
trapped
unsaturated
systems
an
intermolecular
manner,
via
formation
a
C–O
bond.
1
Introduction
2
Reactions
Involving
Carbonyloxy
Radicals
3
Fluoroalkoxy
4
Alkoxy
5
Conclusion
Current Research in Green and Sustainable Chemistry,
Journal Year:
2024,
Volume and Issue:
8, P. 100404 - 100404
Published: Jan. 1, 2024
The
first
electrogeneration
of
O-centered
radicals
from
N-alkoxyphthalimides
via
rapid
alternating
polarity
(RAP)
electrolysis,
using
previous
experimental
conditions
photoredox
catalysis
(PRC)
is
reported.
electrochemical
methodology
emulates
satisfactorily
the
redox
cycle
behavior
accepted
to
explain
PRC
technique.
Notably,
contribution
oxidized
Hantzsch
ester
produced
during
anodic
reaction
emphasized,
which
behaves
as
an
efficient
proton
donor
facilitate
N–O
cleavage
and
extinguish
radical
sequence
efficiently.
conducted
in
a
practical
way
undivided
cell
fitted
with
glassy
carbon
electrodes,
allowing
same
reactions
occur
on
both
electrodes
overall
transformation
reaching
77%
yield
corresponding
alcohol.
This
higher
than
protocol
direct
current
confirming
that
use
RAP
electrolysis
favors
proximity
where
reactive
intermediates
are
produced,
facilitating
their
promote
desired
pathway.
