Design, synthesis, and antiproliferative activity of new 1,2,3-triazole/quinazoline-4-one hybrids as dual EGFR/BRAFV600E inhibitors DOI Creative Commons

Amira M. Mohamed,

Ola M. F. Abou‐Ghadir,

Yaser A. Mostafa

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(52), P. 38403 - 38415

Published: Jan. 1, 2024

A series of new quinazoline/1,2,3-triazole hybrids were designed and synthesized. The compounds evaluated as antiproliferative agents targeting EGFR, BRAF V600E .

Language: Английский

Click-coupling synthesis of new 1-phenacyl-4-substituted 1,2,3-triazoles DOI
Saloomeh Maleki, Mohammad Bakherad, Hossein Nasr‐Isfahani

et al.

Monatshefte für Chemie - Chemical Monthly, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

Citations

0
Isocyanate-based multicomponent reactions DOI Creative Commons

Clara Zavarise,

Jean‐Christophe Cintrat, Eugénie Romero

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(53), P. 39253 - 39267

Published: Jan. 1, 2024

Review on the isocyanate-based multicomponent reaction.

Language: Английский

Citations

2
Recent Developments in C‐S, C‐Se Bond Formation via Three‐Component Reactions of Alkynes DOI Open Access
Zhan‐Yong Wang, Guipeng Feng, Xiaoying Jiang

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(46)

Published: Aug. 28, 2024

Abstract Alkynes are valuable building blocks in organic synthesis. They can undergo three‐component difunctionalization to create sulfur or selenium‐containing compounds. Three‐component reactions of alkynes atom economic, practical and regioselective. This review will disscuss decade developments, including C−S C−Se bond formation via thiolation, sulfonylation selenylation. Recent developments be mainly categorized into three types. (1) Radical C−S/S−Se is a hot topic. Reactions initiated by S/Se radicals other exhibit two types selectivities. Photochemical electrochemical under eco‐friendly conditions have been increasingly reported. (2) Some transformations involve electrophilic three‐membered ring intermediates. Thiiraniums, seleniraniums, iodoniums among the most prevalent species. ring‐opening various nucleophiles participate tandem reactions. (3) Metal‐catalyzed reactions, classic category, also discussed text. In following section, we provide an overview based on mechanisms substrates. The roles added reagents discussed.

Language: Английский

Citations

1
One-pot nucleophilic substitution–double click reactions of biazides leading to functionalized bis(1,2,3-triazole) derivatives DOI Creative Commons
Hans‐Ulrich Reißig, Fei Yu

Beilstein Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 19, P. 1399 - 1407

Published: Sept. 18, 2023

The nucleophilic substitution of benzylic bromides with sodium azide was combined a subsequent copper-catalyzed (3 + 2) cycloaddition terminal alkynes. This one-pot process developed simple model alkyne, but then applied to more complex alkynes bearing enantiopure 1,2-oxazinyl substituents. Hence, the precursor compounds 1,2-, 1,3- or 1,4-bis(bromomethyl)benzene furnished geometrically differing bis(1,2,3-triazole) derivatives. use tris[(1-benzyl-1

Language: Английский

Citations

2
Design, synthesis, and antiproliferative activity of new 1,2,3-triazole/quinazoline-4-one hybrids as dual EGFR/BRAFV600E inhibitors DOI Creative Commons

Amira M. Mohamed,

Ola M. F. Abou‐Ghadir,

Yaser A. Mostafa

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(52), P. 38403 - 38415

Published: Jan. 1, 2024

A series of new quinazoline/1,2,3-triazole hybrids were designed and synthesized. The compounds evaluated as antiproliferative agents targeting EGFR, BRAF V600E .

Language: Английский

Citations

0