Dearomative Ring-Opening of N-Fused Heteroarenes: Access to Tetrasubstituted Alkenes and Ketimines DOI

Qianling Wu,

Xiaojing Wang, Qijian Ni

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

We report a novel and efficient strategy for constructing tetrasubstituted alkenes α-iminonitriles from 3-aminoindolizines 3-aminoimidazo[1,2-a]pyridines. This approach involves dearomative ring-opening of N-fused heteroaromatic amines coupled to DDQ-mediated oxidative process under mild, metal-free conditions. The methodology demonstrates broad substrate scope, excellent functional group tolerance, scalability, offering versatile platform synthesizing complex nitrile-containing frameworks.

Language: Английский

Dearomative Ring-Opening of N-Fused Heteroarenes: Access to Tetrasubstituted Alkenes and Ketimines DOI

Qianling Wu,

Xiaojing Wang, Qijian Ni

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

We report a novel and efficient strategy for constructing tetrasubstituted alkenes α-iminonitriles from 3-aminoindolizines 3-aminoimidazo[1,2-a]pyridines. This approach involves dearomative ring-opening of N-fused heteroaromatic amines coupled to DDQ-mediated oxidative process under mild, metal-free conditions. The methodology demonstrates broad substrate scope, excellent functional group tolerance, scalability, offering versatile platform synthesizing complex nitrile-containing frameworks.

Language: Английский

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