Reactivities and mechanisms in organic reactions involving activation of elemental sulfur under basic conditions

Tetrahedron Chem, Journal Year: 2024, Volume and Issue: 11, P. 100086 - 100086

Published: July 27, 2024

As a readily available and benign waste product of the petrochemical industry, elemental sulfur displays desirable characteristics as raw material for new processes. Accordingly, use reactant or reagent in synthetic organic chemistry receives continuous interest. The implementation procedures often necessitates presence basic nucleophilic compounds, which are known to serve activators, enabling diverse range transformations. However, underlying mechanisms still poorly understood, even synthetically useful well-established reactions that have been decades. While numerous reviews focus on various types products accessible via involving sulfur, this manuscript will put its emphasis common mechanistic steps these transformations, highlighting discussing studies postulated pathways.

Language: Английский

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Recent Developments in Thiochromene Chemistry

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(30), P. 6045 - 6079

Published: Jan. 1, 2024

Thiochromenes are versatile sulfur-containing heterocyclic compounds that have received considerable interest in drug discovery because of their ability to act as crucial building blocks for synthesizing bioactive compounds. In particular, these scaffolds found utility the design anticancer, anti-HIV, antioxidant, and antimicrobial agents, among others. Despite pharmacological potential, synthesis is less explored contrast oxygen-containing counterparts. This review classifies synthetic processes into Michael addition, cycloaddition, ring-opening, coupling, cyclization Diels-Alder reactions, Reaction mechanisms, circumstances, important instances thoroughly discussed each area. For instance, chiral catalysts substrates like mercaptobenzaldehyde cinnamaldehyde used addition achieve excellent enantioselectivity. cycloaddition readily available such thioisatins alkynes regioselectivity product production. also synthesized by ring-opening reactions with epoxides or aziridines. These demonstrate importance solvents reaction control, particularly palladium aryl halides thiol coupling processes. Another major class alkynyl thiols under regulated temperature pressure conditions efficiently synthesize thiochromenes. With use catalysts, increase yields selectivity enhance variety thiochromene emphasizes versatility thiochromenes consolidates existing literature on thiochromenes, scrutinizing gaps opportunities novel thiochromene-containing lead molecules.

Language: Английский

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Synthesis of pyrazolo-azepinone derivatives via Morita–Baylis–Hillman chemistry as potent antimicrobial agents

New Journal of Chemistry, Journal Year: 2023, Volume and Issue: 48(6), P. 2608 - 2623

Published: Dec. 26, 2023

A new MBH reaction mediated approach has been unfolded toward an efficient synthesis of pyrazolo[3,4- c ]azepinone derivatives as potential antimicrobial agents.

Language: Английский

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HFIP‐Mediated Dual C(Ar)‐Alkylation Process towards the Regioselective Synthesis of Triarylmethanes (TRAMs)

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: 19(21)

Published: Aug. 7, 2024

The distinct roles of different chemical species are essential for the discovery novel transformations in organic synthesis. Here, we have designed a potential strategy synthesis triarylmethanes (TRAMs) using dual C(aryl)-alkylation process. This protocol was influenced by 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as pivotal reagent and proceeds through selective para C-H functionalization method. described approach has been proven to be highly efficient terms substrate scope with excellent functional group tolerance gram scale desired product 90 % yield. recyclability reusability HFIP enhanced feasibility this towards sustainable TRAMs.

Language: Английский

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Design of Synthetic Strategies towards Sulfur Containing Scaffolds

Synthesis, Journal Year: 2024, Volume and Issue: 57(02), P. 275 - 295

Published: Aug. 28, 2024

Abstract The utilization of sulfur heterocycles in organic synthesis has attracted significant attention due to their wide-ranging applications. This review showcases the syntheses diverse embedded with amino acid derivatives, polycycles, spirocycles, cyclophanes, and other complex scaffolds. reported methods extend beyond compound highlight use different reagents for constructing heterocycles. Review also discusses utility a variety sulfur-containing starting materials generation target molecules. 1 Introduction 2 Potassium Thioacetate 3 Thiazolidine-2,4-dione 4 Rhodanines 5 Sodium Sulfide 6 Thiotetronic Acid 7 Thiadiazoles 8 Thiophene 9 Rongalite 10 Sulfur Dioxide 11 Divinyl Sulfone 12 Heterocycles Based on Boronic Acids 13 Miscellaneous 14 Summary

Language: Английский

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Sustainable Protocol for Cu-catalysed A3-coupling under solvent-free conditions

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

A Cu-catalyzed three-component cascade reaction has been developed, involving

Language: Английский

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Five-membered ring systems: With more than 1 N atom

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 211 - 257

Published: Jan. 1, 2024

Language: Английский

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Six-membered ring systems: With O and/or S atoms

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 421 - 484

Published: Jan. 1, 2024

Language: Английский

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