Trifluoromethylnitrone: A Versatile Building Block for Synthesizing Trifluoromethyl-Containing Heterocyclic Compounds

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(26), P. 5242 - 5256

Published: Jan. 1, 2024

This review explores the significance of trifluoromethylnitrones in synthesizing fluorine-containing compounds, with a particular focus on trifluoromethylated heterocycles. It versatility trifluoromethylnitrones, especially [3 + 2] cycloaddition reactions, highlighting their unique reactivity various dienophile substrates. Trifluoromethylnitrones are valuable precursors for rapid synthesis medicinally important heterocycles, including isoxazolidines, dihydroisoxazoles, oxathiazolidines, β-lactams, and aziridines. These turn, serve as synthons lactams aminoalcohols. Additionally, nitrone chemistry extends to nucleosides trifluorinated organoborane demonstrating versatility. While sharing similarities trifluorodiazoethane reactivity, offer distinct advantages by enabling heterocycles typically inaccessible trifluorodiazoethane.

Language: Английский

Visible Light-Mediated [1+2+2] Cycloaddition Reaction of Nitroarenes and Alkenes

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

We report a visible light-mediated [1 + 2 2] cycloaddition reaction between nitroarenes and alkenes, conducted under mild conditions, to synthesize isoxazolidines.

Language: Английский

Reagent- and solvent-controlled product divergence in the reaction of trifluorodiazoethane with arylidene-1,3-indanediones

Journal of Fluorine Chemistry, Journal Year: 2024, Volume and Issue: 274, P. 110256 - 110256

Published: Feb. 1, 2024

Language: Английский