Advancements in Desilylation Reactions for the Synthesis of Valuable Organic Molecules DOI
Chuang Liu, Le Zhang,

Qingqing You

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Abstract Silicon, due to its abundance, non‐toxicity, and cost‐effectiveness, is a critical element in the earth's crust with significant industrial applications. In organic chemistry, main group elements, particular silicon, are extensively utilized as versatile synthetic intermediates. Despite current challenges associated harsh reaction conditions unsustainable practices synthesizing crucial structural molecules, desilylation reactions have emerged facilitative method, offering milder operational simplicity. This review provides comprehensive analysis of recent advancements synthesis valuable molecules through two distinct reactions. It systematically presents variety derivatives, such furan, alcohol, N‐heterocyclic, ketone, highlighting broad substrate tolerance these functional compatibility suggests promising future for wide range bioactive underscoring potential contemporary synthesis.

Language: Английский

Iodine(III)-Mediated Keto-oximation of O-Alkynyl Hydroxylamines: A Route to 3-Acyl Isoxazolines and 1,2-Oxazines DOI
Santosh J. Gharpure, Kaushik C. Pansuriya, Juhi Pal

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(45), P. 9787 - 9792

Published: Nov. 4, 2024

An intramolecular iodine(III)-mediated keto-oximation of O-alkynyl hydroxylamines offers rapid and straightforward access to 3-acyl Δ2-isoxazolines 1,2-oxazines. This approach features mild, metal-free, aerobic reaction conditions with good functional group tolerance. Moreover, the synthetic utility this method is demonstrated by synthesis unique structural motifs such as isoxazolidine, 3-vinyl isoxazoline, 2,5-diphenylpyrazine derivatives conversion Δ2-isoxazolines, thereby showcasing its efficiency applicability in chemistry.

Language: Английский

Citations

1
Advancements in Desilylation Reactions for the Synthesis of Valuable Organic Molecules DOI
Chuang Liu, Le Zhang,

Qingqing You

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Abstract Silicon, due to its abundance, non‐toxicity, and cost‐effectiveness, is a critical element in the earth's crust with significant industrial applications. In organic chemistry, main group elements, particular silicon, are extensively utilized as versatile synthetic intermediates. Despite current challenges associated harsh reaction conditions unsustainable practices synthesizing crucial structural molecules, desilylation reactions have emerged facilitative method, offering milder operational simplicity. This review provides comprehensive analysis of recent advancements synthesis valuable molecules through two distinct reactions. It systematically presents variety derivatives, such furan, alcohol, N‐heterocyclic, ketone, highlighting broad substrate tolerance these functional compatibility suggests promising future for wide range bioactive underscoring potential contemporary synthesis.

Language: Английский

Citations

0