Can Conformational Flexibility Influence the Self-Assembly Behavior and Sensing Efficacy of Fluorogenic Amphiphiles? A Case Study with Bisbenzimidazole based Probes DOI

Suraj Pise,

Imran Ahmad, Nilanjan Dey

et al.

Analytical Methods, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

In this work, we have explored the metal ion sensing properties of two bisbenzimidazole-based fluorescent probes, that differ in their conformational flexibility, an aqueous medium. The compound with a flexible methyl spacer (1) experienced blue shifts its absorption and emission maxima (along turn-off response) upon addition Hg2+ ions. On contrary, relatively rigid structure (2) showed red both when treated under similar conditions. Detailed mechanistic studies indicated 1 formed : 2 complex ions, where pyridine nitrogen ends benzimidazole units are involved coordination. However, for 2, binding stoichiometry changed to ions remained connected only through ends. Not did changes molecular level interactions alter optical response, but they also altered efficacy sensing; degree response was more prominent than 2. Also, it observed could dissociate preformed aggregated structures 1, while case promotes aggregate formation. sensor further utilized analysis real-life water samples detection intracellular conditions (HeLa cells).

Language: Английский

Functionalized cyanostilbene-based nano-AIEgens: multipoint binding interactions for improved sensing of gallic acid in real-life food samples DOI

Harshal V. Barkale,

Nilanjan Dey

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(35), P. 8746 - 8756

Published: Jan. 1, 2024

Cyano-substituted stilbene (CSS) derivatives have been synthesized that can form luminescent nanoscopic assemblies in an aqueous medium. The optical properties of such materials, as governed by the relative ratios their monomer and aggregated forms, are found to be susceptible pH temperature compound with boronic acid attached at terminal positions shows a turn-on fluorescence response (LOD: 15.4 ppb) gallic (GA). mechanistic studies indicate 1,2-diol unit GA is involved ester formation residue, while carboxylic end engages hydrogen bonding interaction nitrile unit. Such multi-point binding provides better selectivity over other structurally similar analytes. Moreover, distinct aggregation boronate responsible for GA-specific response. sensory system has utilized determination levels tea (green black tea) various fruit (mango, orange, guava, pomegranate) extracts. In all cases, estimated values GAE were same range reported others. Finally, low-cost, chemically-modified paper strips designed rapid, on-location detection GA.

Language: Английский

Citations

7
Visual detection and tracking of toxic mercury in biological cells using biocompatible mesoporous silica nanospheres DOI
Islam M. El‐Sewify, Mohamed A. Shenashen,

Rasha El-Agamy

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 417, P. 136166 - 136166

Published: June 19, 2024

Language: Английский

Citations

6
Designing Unconventional Molecular Ternary INHIBIT Logic Gate and Crafting Multifunctional Molecular Logic Systems DOI
Monaj Karar,

Harshal V. Barkale,

Sahil D. Vasishtha

et al.

The Journal of Physical Chemistry B, Journal Year: 2024, Volume and Issue: 128(28), P. 6684 - 6692

Published: July 9, 2024

The paper describes an improved method for building flexible interswitchable logic gates such as rare-type molecular ternary INHIBIT and combinational circuits using a specially designed pyridine-end oligo-

Language: Английский

Citations

3
Reversible color changing response of pyrenylated charge-transfer probes towards Hg2+: linker-driven modulation of sensitivity and selectivity DOI Creative Commons
Nilanjan Dey

RSC Advances, Journal Year: 2025, Volume and Issue: 15(13), P. 9587 - 9593

Published: Jan. 1, 2025

Two easily synthesizable prenylated charge transfer probes with a terminal pyridine unit were designed. The compounds differ based on the nature of spacer: rigid olefinic (1) and flexible hydrazo (2). Both show exclusive interaction Hg2+ ions, leading to changes in visible color. Experimental analyses showed that compound 1 outperformed 2 terms sensitivity (A/A 0 ∼ 13-fold vs. ∼2-fold) detection limit (1.2 ppm 5.8 ppm), attributed its linker enhanced binding affinity. Moreover, ratiometric responses (r > 0.99) excellent selectivity for demonstrated. This study highlights development robust, reusable, cost-effective tools mercury detection, thus addressing critical environmental health concerns associated contamination. Environmental robustness was validated across solvents, counter-ions, water mixtures, decreasing efficacy high-water-content systems owing solvation effects probe aggregation. Mechanistic studies confirmed nitrogen as primary coordination site reversible binding, enabling reuse. Practical applications explored using paper strips modified probes, which facilitated rapid, cost-effective, quantitative via image analysis.

Language: Английский

Citations

0
Chromogenic Probes Featuring Hydroxyethyl Acetate as Metal Ion Binding Site: Selective Dual-Mode Response and Quantitative Analysis of Ag+ at Micellar Interface DOI

M Gayathri,

Harshal V. Barkale,

D. Sriram

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 703, P. 135307 - 135307

Published: Sept. 7, 2024

Language: Английский

Citations

2
Nanocarbon eco-hydrogel kit: on-site visual metal ion sensing and dye cleanup, advancing the circular economy in environmental remediation DOI
Omkar S. Nille,

Akanksha G. Kolekar,

Pooja V. Devre

et al.

The Analyst, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

The naked-eye detection of hazardous pollutants through simple and cost-effective techniques with greener circular economy approach is great interest to the scientific community related stakeholders in analytical science.

Language: Английский

Citations

2
Real-Time Optical Detection of Mercury Contamination in Drinking Water using Amphiphilic Recognition Probe at Liquid Crystal/Aqueous Interface DOI
Satyabratt Pandey, Madeeha Rashid, Vishal Singh

et al.

Analytical Methods, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A liquid crystal-sensing platform, leveraging N -dodecylamine-di-thiocarbamate (DDC), enables simple, sensitive, real-time and cost-effective detection of mercury in drinking water, aiding environmental pollution control.

Language: Английский

Citations

1
Can Conformational Flexibility Influence the Self-Assembly Behavior and Sensing Efficacy of Fluorogenic Amphiphiles? A Case Study with Bisbenzimidazole based Probes DOI

Suraj Pise,

Imran Ahmad, Nilanjan Dey

et al.

Analytical Methods, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

In this work, we have explored the metal ion sensing properties of two bisbenzimidazole-based fluorescent probes, that differ in their conformational flexibility, an aqueous medium. The compound with a flexible methyl spacer (1) experienced blue shifts its absorption and emission maxima (along turn-off response) upon addition Hg2+ ions. On contrary, relatively rigid structure (2) showed red both when treated under similar conditions. Detailed mechanistic studies indicated 1 formed : 2 complex ions, where pyridine nitrogen ends benzimidazole units are involved coordination. However, for 2, binding stoichiometry changed to ions remained connected only through ends. Not did changes molecular level interactions alter optical response, but they also altered efficacy sensing; degree response was more prominent than 2. Also, it observed could dissociate preformed aggregated structures 1, while case promotes aggregate formation. sensor further utilized analysis real-life water samples detection intracellular conditions (HeLa cells).

Language: Английский

Citations

0