European Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract We report a Pd‐catalyzed oxidative Pictet‐Spengler reaction/aromatization cascade utilizing readily available benzylic alcohols for the construction of 1‐aryl‐ β ‐carbolines in water. Conceptually, this novel one‐pot, three‐step approach involves an initial Pd(0)/sodium diphenylphosphinobenzene‐3‐sulfonate (TPPMS)‐catalyzed dehydrogenation alcohols, followed by cyclization situ generated aldehydes with tryptamines, and concludes DBU/air‐promoted aromatization, allowing rapid access to desired ‐carbolines. The π ‐benzylPd (II) catalytic system from Pd(0)/TPPMS was found be highly effective alcohol

Language: Английский