No relationship found between dental fluctuating asymmetry, birthweight, and birth term in two modern North American samples DOI
Cait B. McPherson, Lexi O’Donnell, Emily Moes

et al.

American Journal of Human Biology, Journal Year: 2024, Volume and Issue: 36(9)

Published: June 6, 2024

Abstract Objective Deciduous dental crowns primarily develop during gestation and early infancy embody life stress exposures. Composite measures of fluctuating asymmetry (DFA) generated from the deciduous teeth may therefore indicate cumulative gestational in developmental origins health disease (DOHaD) studies. This study examines whether higher composite DFA are associated with low birthweight prematurity, two aspects birth phenotype consistently increased morbidity mortality risks adulthood. Subjects Methods We evaluated associations between DFA, birthweight, term contemporary North American samples: an autopsy sample New Mexico ( n = 94), a growth cohort Burlington, Ontario 304). Dental metric data for each was collected postmortem CT scans casts, respectively. estimated using buccolingual (BL) mesiodistal (MD) crown diameters paired teeth. Results Contrary to expectations, results linear regression indicated no significant relationship or either sample. Conclusions does not predict stress. Birthweight plastic relative more developmentally stable dentition, which only subtly suggest that should be utilized caution DOHaD studies until its is clarified.

Language: Английский

What Doesn't Kill You Makes You Stronger? Examining Relationships Between Early‐Life Stress, Later‐Life Inflammation and Mortality Risk in Skeletal Remains DOI Creative Commons
Ben Wigley, Eleanor Stillman, Elizabeth Craig‐Atkins

et al.

American Journal of Physical Anthropology, Journal Year: 2025, Volume and Issue: 186(2)

Published: Feb. 1, 2025

ABSTRACT Objectives This paper explores conflicting perspectives on the adaptive significance of phenotypic plasticity during fetal and early postnatal development impact that stressors experienced this critical early‐life period have later‐life morbidity mortality risk. Methods The sample ( n = 216) comprised archeologically‐recovered human skeletons. A geometric morphometric (GM) method was employed to evaluate first permanent molar (M1) fluctuating asymmetry (FA) provide a proxy for stress. Shifts in physiology were inferred through two inflammatory lesions: periosteal new bone formation (PNBF) periodontal disease (PD). To explore risk, age‐at‐death estimated dental skeletally immature individuals 104) senescent skeletal changes mature skeletons 112). Results Significant differences found M1 FA between groups, with cohort associated elevated FA. Within‐group analysis revealed group had significant positive relationship PD presence. In group, alongside sex co‐occurrence PNBF, predictor shorter life. Higher also active bilaterally expressed PNBF. Conclusions It is theorized stress, if survived, programmed hyperinflammatory response environmentally‐mediated physiological perturbations which increased chances survival subsequent but Findings demonstrate complicated developmental stress shifts helps illustrate programming support Thrifty Phenotype hypothesis.

Language: Английский

Citations

0
No relationship found between dental fluctuating asymmetry, birthweight, and birth term in two modern North American samples DOI
Cait B. McPherson, Lexi O’Donnell, Emily Moes

et al.

American Journal of Human Biology, Journal Year: 2024, Volume and Issue: 36(9)

Published: June 6, 2024

Abstract Objective Deciduous dental crowns primarily develop during gestation and early infancy embody life stress exposures. Composite measures of fluctuating asymmetry (DFA) generated from the deciduous teeth may therefore indicate cumulative gestational in developmental origins health disease (DOHaD) studies. This study examines whether higher composite DFA are associated with low birthweight prematurity, two aspects birth phenotype consistently increased morbidity mortality risks adulthood. Subjects Methods We evaluated associations between DFA, birthweight, term contemporary North American samples: an autopsy sample New Mexico ( n = 94), a growth cohort Burlington, Ontario 304). Dental metric data for each was collected postmortem CT scans casts, respectively. estimated using buccolingual (BL) mesiodistal (MD) crown diameters paired teeth. Results Contrary to expectations, results linear regression indicated no significant relationship or either sample. Conclusions does not predict stress. Birthweight plastic relative more developmentally stable dentition, which only subtly suggest that should be utilized caution DOHaD studies until its is clarified.

Language: Английский

Citations

1