A flexible catheter-based sensor array for upper airway soft tissues pressure monitoring

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

Abstract Obstructive sleep apnea is a globally prevalent concern with significant health impacts, especially when coupled comorbidities. Accurate detection and localization of airway obstructions are crucial for effective diagnosis treatment, which remains challenge traditional monitoring methods. Here, we report catheter-based flexible pressure sensor array that continuously monitors soft tissue in the upper facilitates at millimeter level. The sensor’s design versatile 3D femtosecond laser fabrication process enable adaptation to diverse materials applications. In vitro testing demonstrates high sensitivity (38.1 Ω/mmHg) excellent stability. effectively distributed accurately identifies an obstructive animal model. this work, highlight potential long-term, continuous its prospective applications other medical devices measurement human body cavities.

Language: Английский

---

The effects of mandibular setback surgery on the upper airway and sleep quality in skeletal Class III patients and comparison with control subjects: a pilot study

International Journal of Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

---

Cognitive Function, Sleep, and Neuroinflammatory Markers in Mice Exposed to Very Long-Term Intermittent Hypoxia

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1815 - 1815

Published: Feb. 20, 2025

Chronic intermittent hypoxia (IH) is one of the hallmark features obstructive sleep apnea (OSA) and adversely affects neurocognitive behavioral functioning. However, how duration IH correlates with its deleterious effects remains unexplored. We aimed to assess over a prolonged period time mimicking untreated OSA. Male C57Bl/6J mice were exposed for 96 weeks. Sleep activity was acquired using piezoelectric system. Novel object recognition (NOR) elevated plus maze test (EPMT) conducted as measures cognitive function anxiety, respectively. Brain inflammation evaluated by panel marker assays. All tests performed after 16 weeks exposure. After weeks, percentages during dark phase decreased in both room air (RA) compared 16-week exposure (RA: p = 0.0214; IH: 0.0188). In addition age-dependent declines NOR performance, had lower preference scores than RA controls (p 0.0070). The spent open arms EPMT reduced RA. Inflammatory expression increased IH-exposed mice. Thus, aging induce similar alterations sleep, cognition, neuroinflammation. are exacerbated concurrent IH, suggesting that OSA disease associated an acceleration biological aging.

Language: Английский

---

Approach the Patient With Obstructive Sleep Apnea and Obesity

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 109(3), P. e1267 - e1279

Published: Sept. 27, 2023

Abstract Obstructive sleep apnea (OSA) and obesity are highly prevalent bidirectionally associated. OSA is underrecognized, however, particularly in women. By mechanisms that overlap with those of obesity, increases the risk developing, or having poor outcomes from, comorbid chronic disorders impairs quality life. Using 2 illustrative cases, we discuss relationships between type diabetes, dyslipidemia, cardiovascular disease, cognitive disturbance, mood disorders, lower urinary tract symptoms, sexual function, reproductive disorders. The differences men women, phenotypic variability OSA, highlighted. When probability high due to consistent comorbidities, both, a diagnostic study advisable. Continuous positive airway pressure mandibular advancement splints improve symptoms. Benefits for comorbidities variable depending on nightly duration use. contrast, weight loss optimization lifestyle behaviors consistently beneficial.

Language: Английский

---

A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 28, 2024

Despite undeniable advances in modern medicine, lung cancer still has high morbidity and mortality rates. Lung is preventable treatable, it important to identify new risk factors for cancer, especially those that can be treated or reversed. Obstructive sleep apnea (OSA) a very common sleep-breathing disorder grossly underestimated clinical practice. It cause, exacerbate, worsen adverse outcomes, including death various diseases, but its relationship with unclear. A possible causal between OSA the onset progression of been established biologically. The pathophysiological processes associated OSA, such as fragmentation, intermittent hypoxia, increased sympathetic nervous excitation, may affect normal neuroendocrine regulation, impair immune function (especially innate cellular immunity), ultimately contribute occurrence accelerate progression, induce treatment resistance. contributor cause cancer. However, whether this effect exists independently other Therefore, by reviewing literature on epidemiology, pathogenesis, we hope understand relationships two promote interdisciplinary exchange ideas basic respiratory oncology.

Language: Английский

---

Obesity and anesthesia

Current Opinion in Anaesthesiology, Journal Year: 2024, Volume and Issue: 37(3), P. 299 - 307

Published: April 1, 2024

Purpose of review Surgical procedures on obese patients are dramatically increasing worldwide over the past few years. In this review, we discuss physiopathology predominantly respiratory system in patients, importance preoperative evaluation, preoxygenation and intraoperative positive end expiratory pressure (PEEP) titration to prevent pulmonary complications optimization airway management oxygenation reduce or postoperative complications. Recent findings Many coming clinic with medication history glucagon-like-peptide 1 agonists ( GLP-1) it has raised many questions regarding Nil Per Os (NPO)/perioperative fasting guidelines due delayed gastric emptying caused by these medications. American Society Anesthesiologists (ASA) come up guiding document help such situations. Ambulatory surgery centers doing more obesity cases a safe manner which were deemed unsafe at one point . Quantitative train four (TOF) monitoring, better neuromuscular reversal agents ultrasounds seemed have made significant impact care perioperative period. Summary Obese higher risk complications, mainly associated those related function. An appropriate management, support monitoring is essential improve outcome increase safety surgical procedure.

Language: Английский

---

Pharmacological treatment for obstructive sleep apnea: A systematic review and meta-analysis

Clinics, Journal Year: 2024, Volume and Issue: 79, P. 100330 - 100330

Published: Jan. 1, 2024

Summarize the evidence on drug therapies for obstructive sleep apnea. The Preferred Reporting Items Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. PubMed, Embase, Scopus, Web of Science, SciELO, LILACS, Cochrane Central Register Controlled Trials, ClinicalTrials.gov searched February 17th, 2023. A search strategy retrieved randomized clinical trials comparing Apnea-Hypopnea Index (AHI) in pharmacotherapies. Studies selected data was extracted by two authors independently. risk bias assessed using Risk Bias tool. RevMan 5.4. used synthesis. 4930 articles obtained, 68 met inclusion criteria, 29 studies (involving 11 drugs) combined a meta-analysis. Atomoxetine plus oxybutynin vs placebo AHI mean difference -7.71 (-10.59, -4.83) [Fixed, 95 % CI, I2 = 50 %, overall effect: Z 5.25, p < 0.001]. Donepezil -8.56 (-15.78, -1.33) 21 2.32, 0.02]. Sodium oxybate -5.50 (-9.28, -1.73) 32 2.86, 0.004]. Trazodone -12.75 (-21.30, -4.19) 0 2.92, 0.003]. combination noradrenergic antimuscarinic drugs shows promising results. Identifying endotypes may be key to future Moreover, with longer follow-up assessing safety sustained effects these treatments are needed. CRD42022362639.

Language: Английский

---

Association between obstructive sleep apnea severity and depression risk: a systematic review and dose-response meta-analysis

Sleep And Breathing, Journal Year: 2024, Volume and Issue: 28(5), P. 2175 - 2185

Published: June 18, 2024

Language: Английский

---

Non-dipping blood pressure pattern is associated with higher risk of new-onset diabetes in hypertensive patients with obstructive sleep apnea: UROSAH data

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 16, 2023

Objective Impairment of circadian blood pressure (BP) patterns has been associated with cardiovascular risks and events in individuals hypertension general populations, which are more likely to be found obstructive sleep apnea (OSA). The aim this study was investigate the association non-dipping BP pattern new-onset diabetes hypertensive patients OSA, based on Urumqi Research Sleep Apnea Hypertension (UROSAH) data. Materials methods This retrospective cohort included 1841 at least 18 years age, who were diagnosed OSA without baseline had adequate ambulatory monitoring (ABPM) data enrollment. exposure interest for present patterns, including dipping pattern, outcome defined as time from diabetes. associations between assessed using Cox proportional hazard models. Results Among participants (mean age: 48.8 ± 10.5 years, 69.1% male), during total follow-up 12172 person-years a median 6.9 (inter quartile range: 6.0-8.0) 217 developed an incidence rate 17.8 per 1000 person-years. proportion non-dippers dippers enrollment 58.8% 41.2%, respectively. Non-dippers higher risk compared (full adjusted ratio [HR]=1.53, 95% confidence interval [CI]: 1.14-2.06, P =0.005). Multiple subgroup sensitivity analyses yielded similar results. We further explored systolic diastolic separately, that HR=1.54, CI: 1.12-2.10, =0.008), whereas non-dippers, nonsignificant after confounding covariates HR=1.35, 0.98-1.86, =0.070). Conclusions Non-dipping is approximately 1.5-fold suggesting may important clinical implication early prevention OSA.

Language: Английский

---

Consensus Statements among European Sleep Surgery Experts on Snoring and Obstructive Sleep Apnea: Part 1 Definitions and Diagnosis

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(2), P. 502 - 502

Published: Jan. 16, 2024

Seeking consensus on definitions and diagnosis of snoring obstructive sleep apnea (OSA) among surgeons is important, particularly in this relatively new field with variability knowledge practices. A set statements was developed based the literature circulated eight panel members European experts, utilizing Delphi method. Responses agreement disagreement each statement comments were used to assess level develop a revised version. The version anonymized sent member as second round. This repeated total five rounds. number included initial 112. In first round, all panelists, percentage questions that had eight, seven, six panelists 45%, 4.5%, 7.1%, respectively. final consisting 99, 8, 7, 6 went up 66.7%, 24.2%, 6.1%, Delphi’s method demonstrated an efficient interaction experts establishment specific statements.

Language: Английский

---