Letter to the Editor Regarding “Tissue Eosinophils Threshold and Its Association With Adult‐Onset Asthma in Chronic Rhinosinusitis”

International Forum of Allergy & Rhinology, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

To the Editor, Kowatanamongkon et al. [1]. recently conducted an exploration into association between tissue eosinophil counts (TEC) in chronic rhinosinusitis (CRS) and development of adult-onset asthma. Their study was designed to establish a TEC threshold that indicates risk asthma individuals with CRS. findings demonstrated ≥40 cells significantly associated asthma, area under curve 0.71 (p < 0.001). The sensitivity this determined be 0.70 (95% confidence interval [CI] = 0.47–0.87), while its specificity 0.66 CI 0.55–0.76). negative predictive value ascertained 0.88, positive 0.37. These indicate elevated could serve as significant prognostic indicator for among proposed holds potential integrated clinical decision-making protocols, aiming optimize long-term respiratory outcomes CRS, direct personalized therapeutic strategies, enhance stratification. Nevertheless, several concerns necessitate further investigation clarification. First foremost, CRS is heterogeneous disease; however, classification subtypes remains indistinct within current meta-analysis. A notable subtype eosinophilic (ECRS), which typified by eosinophil-enriched nasal polyps frequently severe [2]. ECRS entails inflammatory process driven eosinophils, thereby contributing both sinonasal symptoms. Moreover, patients are often afflicted [3], complicating differentiation specific impacts on pathophysiology meta-analysis [4] eighteen studies has robust correlation eosinophilia ECRS. In light these findings, majority incorporated may, fact, have ECRS, leading TEC. This increase likely underlying rather than per se. Consequently, role modulating levels must taken account when interpreting study. Second, exacerbation counts. Mallah [5]. clarified blood count (OR: 1.31 [95% CI: 1.16–1.49]). Research Zeiger [6]. factor exacerbations adults persistent evidence count, underscoring inflammation pathogenesis [1] did not explicitly address whether measured during exacerbation, necessitating additional research authors declare no conflicts interest.

Language: Английский

Response to the Letter to Editor Regarding “Tissue Eosinophils Threshold and Its Association With Adult‐Onset Asthma in Chronic Rhinosinusitis”

International Forum of Allergy & Rhinology, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

The authors declare no conflicts of interest.

Language: Английский