Identification of serum exosomal miRNA biomarkers in patients with lupus nephritis DOI

Fei Chen,

Jia Gao, Bo Shi

et al.

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

Language: Английский

Small Extracellular Vesicles From Hypoxia-Neuron Maintain Blood-Brain Barrier Integrity DOI
Wei Chen,

Yousheng Wu,

Ying Liang

et al.

Stroke, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

BACKGROUND: Acute ischemic stroke disrupts communication between neurons and blood vessels in penumbral areas. How cooperate to achieve blood-brain barrier repair remains unclear. Here, we reveal crosstalk endothelial cells (ECs) mediated by circular RNA originating from oxoglutarate dehydrogenase (CircOGDH). METHODS: We analyzed clinical data patients with acute explore the relationship CircOGDH levels hemorrhagic transformation events. In addition, a middle cerebral artery occlusion reperfusion mouse model neuronal suppression was used assess permeability. ECs increased expression were for changes COL4A4 (collagen type IV alpha 4) levels, vitro coculture experiments conducted examine small extracellular vesicle–mediated transfer ECs. RESULTS: Clinical indicated that reduced correlated stroke. model, impaired restoration of exhibited higher which helped maintain vascular stability. vitro, hypoxic transferred via vesicles, leading elevated enhanced integrity. CONCLUSIONS: Our findings highlight significance neuron-EC vesicles penumbra, emphasizing need balanced intervention strategies management.

Language: Английский

Citations

0
The role of peripheral blood microRNAs in the pathogenesis and treatment response of age-related macular degeneration DOI Creative Commons
Meng Kong,

Jingwen Li,

Nianting Tong

et al.

Future Science OA, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 4, 2025

Age-related macular degeneration is a leading cause of vision loss in aging populations, driven by complex interactions between genetic, environmental, and molecular factors. MicroRNAs have emerged as crucial regulators cellular processes such oxidative stress, inflammation, angiogenesis, all which contribute to AMD pathogenesis. This narrative review aims summarize the involvement peripheral blood microRNAs pathogenesis AMD, focusing on key pathways angiogenesis. Additionally, it explores their potential biomarkers for predicting treatment response, particularly anti-VEGF therapies. The miRNAs noninvasive early diagnosis personalized strategies also explored, highlighting future directions research.

Language: Английский

Citations

0
Extracellular vesicles: translational research and applications in neurology DOI
Apostolos Manolopoulos, Pamela J. Yao, Dimitrios Kapogiannis

et al.

Nature Reviews Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

Citations

0
Design and synthesis of "off-on" fluorescent probes with rapid near-infrared time responsivity for Aβ protein DOI

Pengbo She,

Lei Xing, Mingyang Zhou

et al.

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112844 - 112844

Published: April 1, 2025

Language: Английский

Citations

0
Identification of serum exosomal miRNA biomarkers in patients with lupus nephritis DOI

Fei Chen,

Jia Gao, Bo Shi

et al.

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

Language: Английский

Citations

0