Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade DOI Creative Commons
Qu Tian, Erin Elizabeth Greig, Christos Davatzikos

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 30, 2024

Impaired muscle mitochondrial oxidative capacity is associated with future cognitive impairment, and higher levels of PET blood biomarkers Alzheimer's disease neurodegeneration. Here, we examine its associations up to over a decade-long changes in brain atrophy microstructure. Higher vivo skeletal via MR spectroscopy (post-exercise recovery rate, k

Language: Английский

Cholinergic neurotransmission in the anterior cingulate cortex is associated with cognitive performance in healthy older adults: Baseline characteristics of the Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) trial DOI Open Access
Ana Carolina de Figueiredo Pelegrino, Mouna Attarha, Paule‐Joanne Toussaint

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

ABSTRACT Aging is associated with dysfunction in the cholinergic system, including degeneration of basal forebrain terminals that innervate cortex, which directly contributes to age- and disease-related cognitive decline. In this study, we used [18F]fluoroethoxybenzovesamicol ([18F]FEOBV) positron emission tomography (PET) imaging assess effect age on terminal integrity predefined regions interest its relationship performance healthy older adults who underwent neuropsychological assessment FEOBV PET brain imaging. Our results showed age-related reductions binding, particularly anterior cingulate cortex-our primary region interest-as well as striatum, posterior auditory cortex. Notably, binding cortex was positively correlated NIH EXAMINER Executive Composite Score. These findings suggest [18F]FEOBV can be a reliable biomarker changes human indicate preserving may help maintain function protect against

Language: Английский

Citations

0
The Impact of HIV on Early Brain Aging—A Pathophysiological (Re)View DOI Open Access
Mihai Lazăr, Ruxandra Moroti, Ecaterina Constanța Barbu

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7031 - 7031

Published: Nov. 21, 2024

: This review aims to provide a comprehensive understanding of how HIV alters normal aging trajectories in the brain, presenting HIV-related molecular mechanisms and pathophysiological pathways involved brain aging. The explores roles inflammation, oxidative stress, viral persistence highlighting these factors contribute neuronal damage cognitive impairment accelerate Additionally, it also addresses impact antiretroviral therapy on biological markers associated with its occurrence.

Language: Английский

Citations

0
Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade DOI Creative Commons
Qu Tian, Erin Elizabeth Greig, Christos Davatzikos

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 30, 2024

Impaired muscle mitochondrial oxidative capacity is associated with future cognitive impairment, and higher levels of PET blood biomarkers Alzheimer's disease neurodegeneration. Here, we examine its associations up to over a decade-long changes in brain atrophy microstructure. Higher vivo skeletal via MR spectroscopy (post-exercise recovery rate, k

Language: Английский

Citations

0