The contribution of cerebral small vessel disease in idiopathic normal pressure hydrocephalus: Insights from a prospective cohort study DOI Creative Commons
Hanlin Cai,

Keru Huang,

Feng Yang

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Abstract INTRODUCTION Idiopathic normal pressure hydrocephalus (iNPH) and cerebral small vessel disease (CVSD) are age‐related diseases, but their prevalence clinical relationship unclear. METHODS This prospective cohort study enrolled 95 patients with probable iNPH in China evaluated CSVD burden using magnetic resonance imaging. Linear regression models were used to analyze the association between scores outcomes. RESULTS The results showed 78% of had at least one imaging marker, higher total significantly associated declines attention, executive function, psychomotor speed, gait performance after multivariate adjustments. However, preoperative score did not affect post‐shunt improvement modified Rankin scale or grading scores. DISCUSSION Our findings suggest that is prevalent more severe symptoms, it may shunt Future studies needed elucidate underlying mechanisms. Highlights We found idiopathic type (CSVD) marker. aggravates cognitive impairments effects different markers on cognition worthy further investigation.

Language: Английский

Application and progress of advanced eye movement examinations in cognitive impairment DOI Creative Commons

Qi Leng,

Bo Deng, Yi Ju

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: April 17, 2024

The worldwide incidence of cognitive impairment is escalating, yet no effective solutions for these afflictions have been discovered. Consequently, the importance early identification and immediate intervention heightened. Advanced eye movements-a form voluntary movements that includes anti-saccades, memory-guided saccades, predictive pro-saccades gap/overlap mediated by cerebral cortex subcortical pathways reflect levels functions across different domains. In view their objectivity, reproducibility, non-invasive characteristics, advanced movement examination possesses significant prospective utility a wide range impairment. This paper extensively reviews various models associated with examinations current applications in such as Alzheimer's disease, Lewy body dementia frontotemporal dementia. can serve biomarker screening diagnosis research on future, combining neuropsychological scale assessment other diagnostic methods may contribute to further types diseases.

Language: Английский

Citations

1
Efficacy of high-frequency rTMS in the treatment of gait disorder and cognition in patients with Parkinson’s disease based on wearable devices and eye-movement assessments DOI Creative Commons

Hong Yin Tang,

Xindan Liao,

Peng Li

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Oct. 16, 2024

Background Postural instability and gait disorder cognitive dysfunction are common symptoms of Parkinson’s disease (PD). Scale assessment is frequently used in the clinic to evaluate PD, but this technique limited by its lack sensitivity changes progression difficulty capturing subtle movements function. It currently believed that high-frequency repetitive transcranial magnetic stimulation (rTMS) can improve motor patients with though it remains controversial. Therefore, imperative monitor dynamically identify postural disorder, as well those dysfunction, PD develop targeted interventions. In study, we observed effect rTMS on disorders functions comparing data from wearable devices eye-tracking before after treatment. Methods A total 159 were included study. GYENNO MATRIX analyzer was objective (including timed up-and-go, narrow-track, turning tests), Eyeknow evaluation system patient’s eye movement cognition smooth pursuit, pro-saccade, anti-saccade function–related scales, including Tinetti Balance Scale, Gait Berg Mini-Mental State Examination, Montreal Cognitive Assessment (MoCA), evaluated at same time Results The mean step length, stride velocity, frequency up-and-go test all increased compared treatment, whereas double support decreased. narrow-track test, velocity left duration, right number steps, average duration decreased, while angular Compared latency period overlapping saccades completion saccade speed increased. decreased MoCA scores increased, sub-items improved terms visual–spatial executive function, language, abstraction, delayed recall, orientation Conclusion High-frequency may be an effective therapy for improving PD.

Language: Английский

Citations

1
Eye movement disorders: A new approach to preliminary screening of Parkinson’s disease DOI

Han Li,

Chengqian Li,

Wenqi Ma

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 563, P. 202 - 211

Published: Nov. 14, 2024

Language: Английский

Citations

1
Abnormal eye movements: relationship with clinical symptoms and predictive value for Alzheimer’s disease DOI Creative Commons
Jing Qi,

Teng-hong Lian,

Peng Guo

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 21, 2024

Abnormal eye movements occur at the early stages of Alzheimer's disease (AD). However, characteristics abnormal patients with AD and their relationship clinical symptoms remain inconsistent, predictive value for diagnosing monitoring progression remains unclear.

Language: Английский

Citations

1
Analysis of eye movement features in patients with Alzheimer's disease based on intelligent eye movement analysis and evaluation system DOI Creative Commons
Meichun Tao, Lei Cui, Yuanyuan Du

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Background The early identification of Alzheimer's disease (AD) benefits patients, so creating a simple and convenient method is crucial for diagnosing symptoms. Objective To offer potential approach the detection both AD mild cognitive impairment (MCI). Methods Eye movement data from 66 patients were divided into three groups, including healthy control group (HC), MCI group, group. We searched parameters that can detect at an stage drew receiver operating characteristic (ROC) curves. correlation between eye scores was analyzed. Results differed HC in error correction rate antisaccade ( p = 0.008) total offset degrees (>4°) 0.011) lateral fixation. had different overlap prosaccade accuracy 0.025), latency 0.009) average completion time 0.015), gap 0.005) 0.005), 0.006), < 0.001) saccade velocity 0.035), fixation 0.018), 0.041) compared to significantly 0.044) antisaccades, 0.025) 0.038) prosaccade, these serve as indicators monitor progress disease. Lateral combined with more conducive identifying area under ROC curve 0.837. Most light moderate scores. Conclusions movements be used MCI/AD progression.

Language: Английский

Citations

1
Artificial intelligence–assisted oculo‐gait measurements for cognitive impairment in cerebral small vessel disease DOI Creative Commons
Huimin Chen, Hao Du, Fang Yi

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract INTRODUCTION Oculomotor and gait dysfunctions are closely associated with cognition. However, oculo‐gait patterns their correlation cognition in cerebral small vessel disease (CSVD) remain unclear. METHODS Patients CSVD from a hospital‐based cohort ( n = 194) individuals presumed early community‐based 319) were included. Oculo‐gait measured using the artificial intelligence (AI) –assisted ‘EyeKnow’ eye‐tracking ‘ReadyGo’ motor evaluation systems. Multivariable linear logistic regression models employed to investigate association between parameters RESULTS Anti‐saccade accuracy, stride velocity, swing velocity significantly both patients community dwellers CSVD, could identify cognitive impairment moderate accuracy (area under curve [AUC]: hospital cohort, 0.787; 0.810) after adjusting for age education. DISCUSSION The of features (anti‐saccade velocity) may help screen CSVD. Highlights (lower anti‐saccade (CSVD). Logistic model integrating features, age, education level moderately distinguished status Artificial intelligence–assisted oculomotor measurements provide quick accurate settings.

Language: Английский

Citations

1
Imaging, biomarkers, and vascular cognitive impairment in China: Rationale and design for the VICA study DOI Creative Commons
Mei Cui,

Zishuo Jin,

Yingzhe Wang

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract INTRODUCTION Vascular cognitive impairment (VCI) is highly heterogeneous, with unclear pathogenesis. Individuals vascular risk factors (VRF), cerebral small vessel disease (CSVD), and stroke are all at of developing VCI. To address the growing challenges posed by VCI, “Vascular, Imaging Cognition Association China” (VICA) was established. METHODS VICA aims to recruit 10,000 participants, including 2000 VRF, 3000 CSVD, 5000 patients, form a nationwide multicenter cohort. The study integrates clinical, neuroimaging, multi‐omics data better understand VCI heterogeneity, improve prediction, ensure timely diagnosis. RESULTS has screened 2045 eligible VRF participants from six communities in Wuhan, Shanghai, Taizhou, along 602 CSVD 1269 patients 135 hospitals nationwide. Baseline enrollment follow‐up work still ongoing. DISCUSSION Establishing high‐quality longitudinal cohort crucial for understanding pathogenesis novel markers early screening Highlights Establish large‐scale prospective comprising focusing on high‐risk population China. three‐tier medical network, make full use resources, achieve extensive patients. Utilize multimodal imaging biomarkers lay foundation constructing more‐precise models. Introduce eye movement gait analysis as new methods assessing function. Use positron emission tomography further investigate interaction between neurodegeneration.

Language: Английский

Citations

0
The contribution of cerebral small vessel disease in idiopathic normal pressure hydrocephalus: Insights from a prospective cohort study DOI Creative Commons
Hanlin Cai,

Keru Huang,

Feng Yang

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Abstract INTRODUCTION Idiopathic normal pressure hydrocephalus (iNPH) and cerebral small vessel disease (CVSD) are age‐related diseases, but their prevalence clinical relationship unclear. METHODS This prospective cohort study enrolled 95 patients with probable iNPH in China evaluated CSVD burden using magnetic resonance imaging. Linear regression models were used to analyze the association between scores outcomes. RESULTS The results showed 78% of had at least one imaging marker, higher total significantly associated declines attention, executive function, psychomotor speed, gait performance after multivariate adjustments. However, preoperative score did not affect post‐shunt improvement modified Rankin scale or grading scores. DISCUSSION Our findings suggest that is prevalent more severe symptoms, it may shunt Future studies needed elucidate underlying mechanisms. Highlights We found idiopathic type (CSVD) marker. aggravates cognitive impairments effects different markers on cognition worthy further investigation.

Language: Английский

Citations

0