Nutrition: A non‐negligible factor in the pathogenesis and treatment of Alzheimer's disease

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract Alzheimer's disease (AD) is a degenerative characterized by progressive cognitive dysfunction. The strong link between nutrition and the occurrence progression of AD pathology has been well documented. Poor nutritional status accelerates progress potentially aggravating amyloid beta (Aβ) tau deposition, exacerbating oxidative stress response, modulating microbiota–gut–brain axis, disrupting blood–brain barrier function. advanced stage tends to lead malnutrition due impairments, sensory dysfunctions, brain atrophy, behavioral psychological symptoms dementia (BPSD). This, in turn, produces vicious cycle AD. This review discusses how factors deteriorate each other from early terminal stages AD, focusing on potential different levels factors, ranging micronutrients diet patterns. provides novel insights into reducing risk delaying its progression, improving prognosis. Highlights Two‐fifths cases worldwide have attributed modifiable factors. Up ≈26% community‐dwelling patients with are malnourished, compared 7%∼76% institutionalized patients. Undernutrition effects onset, prognosis through multiple mechanisms. Various supports were confirmed be protective for via specific

Language: Английский

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Healthy dietary patterns in relation to cognitive performance and Alzheimer's disease mortality

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100100 - 100100

Published: March 1, 2025

Dietary factors play a major role in cognitive aging, but few studies have assessed and compared the associations between specific dietary patterns Alzheimer's disease (AD) mortality. We included 27,773 U.S. participants (mean age = 59.8 years, 51.4 % female) from National Health Nutrition Examination Survey (NHANES) 1998 2016, with follow-up for AD mortality until December 2019. Five pattern scores were calculated utilizing one (1999-2002) or two repeated (2003-2016) 24hr recalls, including Healthy Eating Index (HEI-2015), healthful plant-based diet index (hPDI), alternate Mediterranean (aMED), Approach to Stop Hypertension (DASH), Mediterranean-DASH Intervention Neurodegeneration Delay (MIND) scores. utilized Cox proportional hazard models evaluate of these A total 260 deaths occurred during median 9.8 years. Higher aMED score was associated lower risk (HRT3vs T1: 0.72, 95 CI, 0.52-1.00, p-trend 0.041). In sub-sample 2,713 NHANES 2011-2014, 432 individuals had prevalent psychometric mild impairment (p-MCI). aMED, MIND, HEI-2015, hPDI odds p-MCI. The potential contributors higher intake levels vegetables nuts, moderate alcohol consumption, level sweets. more favorable outcomes among middle-aged older adults, underscoring importance healthy long-term benefits brain health.

Language: Английский

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Effects of sleep deprivation on brain atrophy in individuals with mild cognitive impairment and Alzheimer's disease

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102397 - 102397

Published: June 27, 2024

Language: Английский

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Clinical and neuroimaging association between neuropsychiatric symptoms and nutritional status across the Alzheimer's disease continuum: a longitudinal cohort study

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(3), P. 100182 - 100182

Published: Feb. 9, 2024

To investigate the association between neuropsychiatric symptoms (NPS) and nutritional status, explore their shared regulatory brain regions on Alzheimer's disease (AD) continuum. A longitudinal, observational cohort study. Data were collected from Chinese Imaging, Biomarkers, Lifestyle study June 1, 2021 December 31, 2022. Overall, 432 patients AD continuum, including amnestic mild cognitive impairment dementia, assessed at baseline, only 165 completed (10.37 ± 6.08) months' follow-up. The Mini-Nutritional Assessment (MNA) Neuropsychiatric Inventory (NPI) used to evaluate status NPS, respectively. corrected cerebral blood flow (cCBF) measured by pseudo-continuous arterial spin labeling of dietary nutrition-related was analyzed. NPS baseline subsequent change in changes severity examined using generalized linear mixed models. Increased cCBF left putamen associated with malnutrition, general affective symptoms, hyperactivity (P < 0.05). presence (β = −1.317, P 0.003), −1.887, 0.001), appetite/eating disorders −1.714, 0.001) a decline MNA scores during higher NPI −0.048), −0.181), −0.416; all longitudinally lower after adjusting for confounding factors. We found that predictors worse disorders, poorer status. Furthermore, abnormal perfusion may regulate malnutrition which suggests potentially common neural basis.

Language: Английский

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Associations of the Mediterranean‐DASH Intervention for Neurodegenerative Delay diet with brain structural markers and their changes

Alzheimer s & Dementia, Journal Year: 2023, Volume and Issue: 20(2), P. 1190 - 1200

Published: Nov. 6, 2023

Abstract INTRODUCTION The associations of the Mediterranean‐DASH Intervention for Neurodegenerative Delay (MIND) diet with brain structural changes are unclear. METHODS Among 26,466 UK Biobank participants, a 15‐point MIND score was calculated from 24‐hour recalls 2009 to 2012. We assessed its 17 magnetic‐resonance‐derived volumetric markers and their longitudinal explored whether genetic factors modify associations. RESULTS Higher adherence associated larger volumes thalamus, putamen, pallidum, hippocampus, accumbens (beta per 3‐unit increment ranging 0.024 0.033) lower white matter hyperintensities ( P ‐trends < 0.05), regardless predispositions Alzheimer's disease. not > 0.05) over median 2.2 years among participants repeated imaging assessments N = 2963), but slower atrophy in putamen (beta: 0.026, ‐trend 0.044) pallidum 0.030, APOE ε4 non‐carriers 654). DISCUSSION showed beneficial certain markers, long‐term warrants future investigation. Highlights Adherence significantly higher gray regions adults, were modified by factors. No significant observed between investigated years. non‐carriers.

Language: Английский

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Diets to promote healthy brain ageing

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Language: Английский

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Circulating metabolomic profile of the MIND diet and its relation to cognition in middle‐aged and older adults

iMetaOmics., Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Language: Английский

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Nootropic foods in neurodegenerative diseases: mechanisms, challenges, and future

Translational Neurodegeneration, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 3, 2025

Neurodegenerative diseases (NDDs) such as Alzheimer's and Parkinson's disease are increasing globally represent a significant cause of age-related death in the population. Recent studies emphasize strong association between environmental stressors, particularly dietary factors, brain health neurodegeneration unsatisfactory outcomes. Despite ongoing efforts, efficiency current treatments for NDDs remains wanting. Considering this, nootropic foods with neuroprotective effects high interest part possible long-term therapeutic strategy to improve alleviate NDDs. However, since it is new emerging area food neuroscience, there limited information on mechanisms challenges consider this be successful intervention. Here, we seek address these gaps by presenting comprehensive review pathways or including mutual interactions governing metabolism, linkages NDDs, intake, properties foods. We also discuss in-depth intervention compounds patterns providing detailed exploration their action. Additionally, analyze demand, challenges, future directions development targeting

Language: Английский

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Role of dietary fiber and short-chain fatty acids in preventing neurodegenerative diseases through the gut-brain axis

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106870 - 106870

Published: May 9, 2025

Language: Английский

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Greater adherence to the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet is associated with lower risk of inflammatory bowel disease: a prospective cohort study

Food & Function, Journal Year: 2024, Volume and Issue: 15(14), P. 7631 - 7640

Published: Jan. 1, 2024

Background: The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet is emerging as a promising candidate preventive measures against inflammatory bowel disease (IBD), though there currently no direct evidence from population-based studies. This study aims to bridge the gap in understanding of association MIND with IBD risk. Methods: We utilized data 187 490 participants UK Biobank who provided dietary information and were free at baseline. Dietary was obtained using validated web-based 24-hour recall questionnaire. A score evaluated based on intake ten beneficial five unhealthy food groups scores further grouped into tertiles. outcome interest incident IBD, Crohn's (CD), ulcerative colitis (UC). Multivariable-adjusted hazard ratios (HRs) 95% confidence intervals (CIs) estimated Cox proportional models adjusted demographic characteristics, lifestyle factors, cancer history, other factors. Mediation analyses performed evaluate role systemic inflammation metabolic disorders represented by integrated biomarkers diet-IBD association. Results: After mean follow-up 10.7 years, we documented 825 cases (250 CD 575 UC). average age 56.2 which 55.0% females. found that greater adherence diet, higher score, associated lower risk (HRcomparing extreme tertiles 0.74, CI 0.62-0.90, p = 0.002; trend 0.005), (HR 0.66, 0.47-0.94, 0.022; 0.023), UC 0.78, 0.62-0.98, 0.031; 0.022). associations partially mediated status (mediation proportion: 5.5-15.9%). Conclusion: conditions may play an important underlying mechanistic pathways.

Language: Английский

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