O PAPEL DAS GALECTINAS NA INFLAMAÇÃO E MIELINIZAÇÃO EM DISFUNÇÕES COGNITIVAS DE DISTÚRBIOS NEUROLÓGICOS DOI Open Access

Celina Cavalcante Muniz Gomes,

Joelson Germano Crispim,

Ykaro Gabriel Menezes Bezerra

et al.

Inova Saúde, Journal Year: 2024, Volume and Issue: 14(5), P. 173 - 181

Published: June 28, 2024

Distúrbios neurológicos (DNs) têm crescido junto ao envelhecimento e aumento populacional global, sendo um desafio sistema de saúde pública. DNs envolvem disfunções sinápticas moleculares que comprometem a cognição, memória aprendizado. As galectinas (gal) são potenciais moduladoras da neuroinflamação, com expressão neurológica. Assim, tem-se como objetivo entender associação entre as galectinas, vias celulares na fisiopatologia DNs. Realizou-se uma revisão narrativa nas bases dados Pubmed, LILACS Scielo, palavras-chave em inglês português “galectins” and “cognition”. 23 estudos in vivo, vitro post-mortem foram incluídos nesta revisão. Na Doença Alzheimer (DA), isquemia/reperfusão renal (IR), HIV, malária cerebral esquizofrenia, diversos mostraram relação significativa aumentada ou reduzida gal-3, gal-9, gal-8 gal-1 marcadores pró-inflamatórios anti-inflamatórios, neurodegenerativos sinápticos. DA, apneia obstrutiva do sono IR, o silenciamento inibição farmacológica gal-3 atenuou neuroinflamação apoptose neuronal, gerou proteção contra neurotoxicidade melhorou comprometimento cognitivo. isquemia administração remielinização atenuação déficits cognitivos. Concluiu-se –1, –3, -4, -8 –9 modulam processos neuroinflamatórios presentes cognitivas DNs, alvos terapêuticos. Palavras-chave: galectinas; cognição; neurofisiologia; inflamação; mielina.

Innate immune activation in neurodegenerative diseases DOI
Sergio Castro‐Gomez, Michael T. Heneka

Immunity, Journal Year: 2024, Volume and Issue: 57(4), P. 790 - 814

Published: April 1, 2024

Language: Английский

Citations

21
Serum Galectin-3 and IL-6 as Inflammatory Markers in Bipolar Disorder: Insights from Manic and Euthymic Episodes DOI Open Access
Alev Lazoğlu Özkaya, Nilifer Gürbüzer, Elif Özcan Tozoğlu

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 803 - 803

Published: Jan. 26, 2025

Objectives: This study aimed to assess serum Galectin-3 (Gal-3) and IL-6 levels, along with other inflammatory markers, in type-1 bipolar disorder (BD) patients explore their relationship clinical features, metabolic parameters, symptom severity. Background: The included 38 manic, 35 euthymic BD patients, 40 healthy controls. Sociodemographic data, such as age, gender, alcohol smoking habits, body mass index (BMI), were recorded. Methods: Young Mania Rating Scale (YMRS) Hamilton Depression (HAM-D) administered patients. Biochemical measurements Gal-3, IL-6, CRP, neutrophil, lymphocyte, platelet counts, indices like NLR, PLR, SII, SIRI. Results: Gal-3 levels significantly differed among the groups (F = 52.251, p < 0.001), highest elevated both manic compared controls 7.379, 0.001). Manic had higher of neutrophils, monocytes, A positive correlation was found between total number episodes, YMRS scores In correlated positively disease duration episode count. Conclusions: Elevated particularly phase, may serve a biomarker for indicate ongoing inflammation. These findings suggest could help identify differentiate phase.

Language: Английский

Citations

1
Ai-Driven Discovery of Brain-Penetrant Galectin-3 Inhibitors for Alzheimer's Disease Therapy DOI
Zu‐Cheng Ye, Xueyan Liu,

Jiexin Xu

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

1
Lysosome quality control in health and neurodegenerative diseases DOI Creative Commons
Veronica Ferrari, B. Tedesco, Marta Cozzi

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: Sept. 5, 2024

Abstract Lysosomes are acidic organelles involved in crucial intracellular functions, including the degradation of and protein, membrane repair, phagocytosis, endocytosis, nutrient sensing. Given these key roles lysosomes, maintaining their homeostasis is essential for cell viability. Thus, to preserve lysosome integrity functionality, cells have developed a complex system, called quality control (LQC). Several stressors may affect causing Lysosomal permeabilization (LMP), which rupture results leakage luminal hydrolase enzymes into cytosol. After sensing damage, LQC either activates or induces ruptured lysosomes through autophagy. In addition, stimulates de novo biogenesis functional exocytosis. Alterations give rise deleterious consequences cellular homeostasis. Specifically, persistence impaired malfunctioning lysosomal processes leads toxicity death, thereby contributing pathogenesis different disorders, neurodegenerative diseases (NDs). Recently, several pieces evidence underlined importance role NDs. this review, we describe elements how they cooperate maintain homeostasis, implication Graphical

Language: Английский

Citations

4
Effects of Troxerutin on Oxidative Stress, Inflammation and Galectin- 3 Expression in Intracerebroventricular Kainic Acid-Induced Neurotoxicity DOI Creative Commons
Mehmet Demir, Hülya Elbe, Dilan ÇETİNAVCI

et al.

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

0
Galectin‐3 is upregulated in frontotemporal dementia patients with subtype specificity DOI Creative Commons
Sergi Borrego‐Écija, Agnès Pérez‐Millan, Anna Antonell

et al.

Alzheimer s & Dementia, Journal Year: 2023, Volume and Issue: 20(3), P. 1515 - 1526

Published: Nov. 29, 2023

Abstract INTRODUCTION Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin‐3 (Gal‐3), microglial activation regulator, holds promise as therapeutic target and potential biomarker. Our study aimed investigate Gal‐3 levels in patients with FTD assess its diagnostic potential. METHODS We examined brain, serum, cerebrospinal fluid (CSF) samples controls. Multiple linear regressions between other markers were explored. RESULTS increased significantly FTD, mainly across brain tissue CSF, compared Remarkably, higher cases tau pathology than TAR‐DNA Binding Protein 43 (TDP‐43) pathology. Only MAPT mutation carriers displayed CSF samples, which correlated total 14‐3‐3. DISCUSSION findings underscore marker for particularly cases, highlights relation neuronal injury markers.

Language: Английский

Citations

8
Changes in urinary proteins of unaffected individuals with a family history of frontotemporal dementia DOI Open Access

Yan Su,

Min Chu, Haitong Wang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Frontotemporal dementia (FTD) is a very common type of neurodegenerative and the main cause in people under 65 years old. It has strong heritability. To explore whether there are urinary proteins biological pathways that different between those who have not been identified with FTD existing diagnostic methods healthy people, this study conducts proteomics analysis on without disease family history people. The results show 387 significantly (P<0.01; FC≥2.0 or ≤0.5) two groups. Among them, many reported to play role nervous system. In particular, Progranulin (PGRN) considered an effective biomarker for FTD. 139 enriched by differential (P<0.01), directly related neurons system, including glial cells microglia. differences proteomes make potential provide clues exploring patient populations mechanisms early occurrence development FTD, opening up new perspective prevention diagnosis.

Language: Английский

Citations

0
O PAPEL DAS GALECTINAS NA INFLAMAÇÃO E MIELINIZAÇÃO EM DISFUNÇÕES COGNITIVAS DE DISTÚRBIOS NEUROLÓGICOS DOI Open Access

Celina Cavalcante Muniz Gomes,

Joelson Germano Crispim,

Ykaro Gabriel Menezes Bezerra

et al.

Inova Saúde, Journal Year: 2024, Volume and Issue: 14(5), P. 173 - 181

Published: June 28, 2024

Distúrbios neurológicos (DNs) têm crescido junto ao envelhecimento e aumento populacional global, sendo um desafio sistema de saúde pública. DNs envolvem disfunções sinápticas moleculares que comprometem a cognição, memória aprendizado. As galectinas (gal) são potenciais moduladoras da neuroinflamação, com expressão neurológica. Assim, tem-se como objetivo entender associação entre as galectinas, vias celulares na fisiopatologia DNs. Realizou-se uma revisão narrativa nas bases dados Pubmed, LILACS Scielo, palavras-chave em inglês português “galectins” and “cognition”. 23 estudos in vivo, vitro post-mortem foram incluídos nesta revisão. Na Doença Alzheimer (DA), isquemia/reperfusão renal (IR), HIV, malária cerebral esquizofrenia, diversos mostraram relação significativa aumentada ou reduzida gal-3, gal-9, gal-8 gal-1 marcadores pró-inflamatórios anti-inflamatórios, neurodegenerativos sinápticos. DA, apneia obstrutiva do sono IR, o silenciamento inibição farmacológica gal-3 atenuou neuroinflamação apoptose neuronal, gerou proteção contra neurotoxicidade melhorou comprometimento cognitivo. isquemia administração remielinização atenuação déficits cognitivos. Concluiu-se –1, –3, -4, -8 –9 modulam processos neuroinflamatórios presentes cognitivas DNs, alvos terapêuticos. Palavras-chave: galectinas; cognição; neurofisiologia; inflamação; mielina.

Citations

0