Identification of blood transcriptome modules associated with suicidal ideation in patients with major depressive disorder DOI Creative Commons
Min Wang,

Hailin Xiang,

Jinxue Wei

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 7, 2025

The risk of suicide in patients with major depressive disorder (MDD) poses a concern, studies suggesting that genetics may be contributing factor. Although there are many transcriptomic on postmortem brain tissue related to suicidal behavior, the blood transcriptional mechanisms ideation (SI) remain unknown. This study utilized weighted gene coexpression network analysis (WGCNA) approach investigate associations between modules and SI individuals MDD using peripheral RNA-seq data from 75 (MDD_SI), 82 without (MDD_nSI), 149 healthy controls (HC). An ANCOVA was conducted assess differences among groups, age sex included as covariates. ontology (GO) Kyoto encyclopedia genes genomes (KEGG) databases were used annotate module functions. Results indicated magenta (associated RNA splicing processes) differentiated MDD_SI MDD_nSI (p = 0.021), while green (related immune inflammatory responses) distinguished HC 0.004). Additionally, three showed HC: 0.009), brown innate immunity mitochondrial metabolism; p 0.001), turquoise energy metabolism neurodegeneration; 0.005). Our findings highlight expression regulation, response, inflammation linked MDD, pathways associated immunity, metabolism, function, neurodegeneration appear more broadly MDD.

Language: Английский

The relationship between sarcopenia and mental health status in Chinese older adults: the mediating role of activities of daily living DOI Creative Commons

Huaiju Ge,

Shanshan Yang, Wenyu Su

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 29, 2025

Most existing studies focus on either the relationship between sarcopenia and depressive symptoms or cognitive functions. Few have examined functions simultaneously. This study aimed to analyze both in elderly by introducing activities of daily living explore mediating role mental health. used data from 2015 2018 China Health Retirement Longitudinal Study, including a total 3,552 older adults aged 60 above. We conducted descriptive statistical analysis correlation seemingly unrelated regression examine sarcopenia, symptoms, adults. Bootstrap mediation was further elderly. After adjusting for confounding factors, positively correlated with (β = 0.663, p < 0.001) negatively (β=-0.748, 0.001), indicating negative impact Activities mediated health, stronger effect (18.77%, β 0.125, 95%CI (0.035, 0.222)) than (12.82%, β=-0.099, (-0.162, -0.035)). partially health status Chinese Interventions targeting may be an effective way prevent improve

Language: Английский

Citations

4
The interaction between circadian syndrome and genetic susceptibility in the risk of incident dementia: A longitudinal cohort study DOI Creative Commons
Linling Yu, Wei Liu,

Cai-Ceng Liao

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100089 - 100089

Published: Feb. 1, 2025

Despite growing interest in circadian disturbances as potential triggers for dementia, the specific impact of syndrome (CircS) on dementia incidence remains poorly understood. Moreover, role genetic susceptibility modulating these effects to be explored. Dementia-free participants from UK Biobank cohort were included analysis. To evaluate association between CircS and well modifying influence this relationship, Cox proportional hazards models utilized. During a median follow-up period 14.55 years, 3,965 incident cases documented. was found significantly increased risk with hazard ratio (HR) 1.401 (95 % confidence interval [CI]: 1.296, 1.516). Compared score ≤3, mild (HR: 1.259, 95 CI: 1.146-1.383), moderate 1.667, 1.461-1.903), severe 2.028, 1.397-2.944) all associated an elevated dementia. There significant multiplicative interactions (Pinteraction<0.001). Participants both high polygenic (PRS) had highest 2.551, 2.169, 3.001), compared those low PRS no CircS. which might aggravated by susceptibility.

Language: Английский

Citations

2
20‐year depressive symptoms, dementia, and structural neuropathology in older women DOI Creative Commons
Andrew J. Petkus, Xinhui Wang, Diana Younan

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(5), P. 3472 - 3484

Published: April 9, 2024

The course of depressive symptoms and dementia risk is unclear, as are potential structural neuropathological common causes.

Language: Английский

Citations

4
Identification of blood transcriptome modules associated with suicidal ideation in patients with major depressive disorder DOI Creative Commons
Min Wang,

Hailin Xiang,

Jinxue Wei

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 7, 2025

The risk of suicide in patients with major depressive disorder (MDD) poses a concern, studies suggesting that genetics may be contributing factor. Although there are many transcriptomic on postmortem brain tissue related to suicidal behavior, the blood transcriptional mechanisms ideation (SI) remain unknown. This study utilized weighted gene coexpression network analysis (WGCNA) approach investigate associations between modules and SI individuals MDD using peripheral RNA-seq data from 75 (MDD_SI), 82 without (MDD_nSI), 149 healthy controls (HC). An ANCOVA was conducted assess differences among groups, age sex included as covariates. ontology (GO) Kyoto encyclopedia genes genomes (KEGG) databases were used annotate module functions. Results indicated magenta (associated RNA splicing processes) differentiated MDD_SI MDD_nSI (p = 0.021), while green (related immune inflammatory responses) distinguished HC 0.004). Additionally, three showed HC: 0.009), brown innate immunity mitochondrial metabolism; p 0.001), turquoise energy metabolism neurodegeneration; 0.005). Our findings highlight expression regulation, response, inflammation linked MDD, pathways associated immunity, metabolism, function, neurodegeneration appear more broadly MDD.

Language: Английский

Citations

0